2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptoms
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhood
2016
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis
O'Donnell KJ, Meaney MJ. Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis. American Journal Of Psychiatry 2016, 174: 319-328. PMID: 27838934, DOI: 10.1176/appi.ajp.2016.16020138.BooksMeSH KeywordsAffectBirth WeightBrainChildChild, PreschoolChronic DiseaseFemaleFetal DevelopmentFetal Growth RetardationGene-Environment InteractionGlucocorticoidsHumansInfantInfant, NewbornMaleMaternal HealthMental DisordersNeurodevelopmental DisordersPregnancyPrenatal Exposure Delayed EffectsPsychopathologyRisk FactorsStress, PsychologicalTemperamentConceptsFetal growthMental healthFetal originLater psychopathologyMaternal mental healthDevelopmental originsNeurodevelopmental outcomesFetal neurodevelopmentChronic illnessObservational studyMaternal adversityMaternal anxietyStress mediatorsClinical relevanceFetal developmentPostnatal influencesAdult HealthDisease hypothesisFindings parallel studiesNeurodevelopmentGenetic factorsEmotional wellIllnessHealthRisk