2024
Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depression
2023
Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohort