2023
Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesA Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental healthInvestigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylation
2022
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbility
2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding
2018
Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment
Bouvette-Turcot A, Meaney M, O’Donnell K. Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment. Child Maltreatment Solutions Network 2018, 89-119. DOI: 10.1007/978-3-319-72589-5_7.Peer-Reviewed Original ResearchMental healthEarly adversityEarly life adversityLater mental healthEarly childhood adversityLater riskClinical studiesPreclinical modelsCurrent evidenceMental disordersChildhood adversityLife adversityPutative mechanismsNeural developmentDNA methylationEarly social environmentChild maltreatmentEarly environmentHealthAdversityEpigenetic mechanisms
2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal life
2016
The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity
Sokolowski HM, Vasquez OE, Unternaehrer E, Sokolowski DJ, Biergans SD, Atkinson L, Gonzalez A, Silveira PP, Levitan R, O’Donnell K, Steiner M, Kennedy J, Meaney MJ, Fleming AS, Sokolowski MB, teams O. The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity. Cognitive Development 2016, 42: 62-73. PMID: 28827895, PMCID: PMC5562168, DOI: 10.1016/j.cogdev.2016.11.001.Peer-Reviewed Original ResearchGenetic variationCGMP-dependent protein kinaseAdult fruit fliesForaging (for) geneSocial insectsFruit flyProtein kinaseDrosophilaGene-environment interactionsGenesAllelesInsectsEarly environmentKinasePRKG1GeneticsFliesAdult individual differencesSelf-reported childhood adversityVariationC alleleMaternal adversityAssociatesEarly life adversityRs2043556
2014
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.Peer-Reviewed Original ResearchConceptsExpression of genesParent-offspring interactionsEpigenetic stateEpigenetic mechanismsEpigenetic programmingEpigenetic studiesStress responseGenesNonhuman speciesAdrenal functionExpressionSpeciesEarly life adversityEarly childhood adversityLater riskFuture studiesChildhood adversityLife adversityFunctionSocial adversityAlters