2021
Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study
Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circulation Cardiovascular Imaging 2021, 14: e011753. PMID: 34256573, PMCID: PMC8323993, DOI: 10.1161/circimaging.120.011753.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAsymptomatic DiseasesCoronary AngiographyCoronary Artery DiseaseDiffusion Tensor ImagingFemaleHumansLeukoencephalopathiesMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSex FactorsTime FactorsVascular CalcificationConceptsCoronary artery calciumWhite matter injurySubtle white matter injuryAsymptomatic middle-aged menCAC scoreMiddle-aged menFractional anisotropyCAC groupDiffusion tensor imaging-based measuresCarotid-femoral pulse wave velocityLog-transformed CAC scoreSecondary analysisBrain magnetic resonance imagingPredictors of strokePulse wave velocityCross-sectional associationsMagnetic resonance diffusion tensorImaging-based measuresMagnetic resonance imagingLower fractional anisotropyFramingham Heart StudyMiddle-age adultsArtery calciumMultivariable adjustmentAortic stiffness
2019
Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume
Spartano NL, Davis-Plourde KL, Himali JJ, Andersson C, Pase MP, Maillard P, DeCarli C, Murabito JM, Beiser AS, Vasan RS, Seshadri S. Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume. JAMA Network Open 2019, 2: e192745. PMID: 31002329, PMCID: PMC6481600, DOI: 10.1001/jamanetworkopen.2019.2745.Peer-Reviewed Original ResearchConceptsLight-intensity physical activityTotal brain volumeHigher total brain volumeMagnetic resonance imagingPA guidelinesPhysical activityBrain volumeBrain agingVigorous PA levelsCommunity-based cohort studyPA levelsBrain magnetic resonance imagingAssociation of accelerometerCurrent PA guidelinesBrain MRI measuresFramingham Heart Study participantsVigorous physical activityAdditional hourMost older adultsFramingham Heart StudyHigher brain volumesCohort studyDementia preventionDementia riskMean age