2019
DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY
Lin I, Oldham M, Hawkins K, Scoutt L, Yuh D, Lee H. DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY. American Journal Of Geriatric Psychiatry 2019, 27: s160-s161. DOI: 10.1016/j.jagp.2019.01.113.Peer-Reviewed Original ResearchMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityArtery bypass graft surgeryBilateral middle cerebral arteriesPreoperative cognitive assessmentBypass graft surgeryConfusion Assessment MethodCoronary artery bypassRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingPutative risk factorsResults Average ageCI 1.3Preoperative depressionStructured HamiltonStudy psychiatristArtery bypass
2018
Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study
Oldham MA, Hawkins KA, Lin IH, Deng Y, Hao Q, Scoutt LM, Yuh DD, Lee HB. Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study. American Journal Of Geriatric Psychiatry 2018, 27: 476-486. PMID: 30709616, PMCID: PMC6443412, DOI: 10.1016/j.jagp.2018.12.025.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityProspective observational cohort studyArtery bypass graft surgeryBilateral middle cerebral arteriesTertiary care academic hospitalHeart Surgery studyPreoperative cognitive assessmentUndergoing CABG surgeryBypass graft surgeryConfusion Assessment MethodRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingDepression InterviewPreoperative depressionStructured HamiltonStudy psychiatristThe effect of age and smoking on the hippocampus and memory in late middle age
Hawkins KA, Emadi N, Pearlson GD, Taylor B, Khadka S, King D, Blank K. The effect of age and smoking on the hippocampus and memory in late middle age. Hippocampus 2018, 28: 846-849. PMID: 30070068, DOI: 10.1002/hipo.23014.Peer-Reviewed Original ResearchConceptsSmoking historyHippocampal volumeHeavy smoking historyVascular risk factorsMiddle-aged subjectsMRI brain scanningAPOE e4 genotypeEffect of ageHeavy smokingHippocampal atrophyAlcohol historyRisk factorsE4 genotypeBrain scanningAPOE e4Neuropsychological assessment batteryHippocampus atrophyFemale subjectsGlobal cognitionMemory disordersData extractionMemory declineAssessment BatteryAgeSmoking
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2007
Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
Hoffman RE, Woods SW, Hawkins KA, Pittman B, Tohen M, Preda A, Breier A, Glist J, Addington J, Perkins DO, McGlashan TH. Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population. The British Journal Of Psychiatry 2007, 191: 355-356. PMID: 17906248, DOI: 10.1192/bjp.bp.106.031195.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersTime-dependent Cox regression analysisCox regression analysisMedication-free intervalOlanzapine treatmentPlacebo groupPharmacological treatmentProdromal symptomsRisk factorsProdromal populationSpeech illusionsDisordersRegression analysisYear 2TreatmentSignificant interactionYear 1Symptoms