2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2
Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.m116.770883.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsApoptosisBreast NeoplasmsCalciumCell Line, TumorCell MembraneCell ProliferationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesHSP90 Heat-Shock ProteinsHumansMiceMicroscopy, FluorescencePhosphoproteinsPlasma Membrane Calcium-Transporting ATPasesReceptor, ErbB-2RNA, MessengerSignal TransductionSodium-Hydrogen ExchangersConceptsBreast cancerHER2-positive breast cancerHER2-positive statusInvasive breast cancerHuman ductal carcinomaDegradation of HER2Normal mammary epithelial cellsMalignant breast cellsBreast cancer cellsErbB2/HER2Tyrosine kinase HER2Sodium-hydrogen exchanger regulatory factor-1Ductal carcinomaHER2 expressionExchanger regulatory factor 1Mammary epithelial cellsHER2Regulatory factor 1NHERF1 expressionBreast cellsEpithelial cellsCancerCancer cellsFactor 1PMCA2
2001
Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas
VanHouten J, Asch H, Asch B. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. Oncogene 2001, 20: 5366-5372. PMID: 11536049, DOI: 10.1038/sj.onc.1204701.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, WesternCloning, MolecularConcanavalin ADNA, ComplementaryEndoplasmic ReticulumExtracellular MatrixHumansMammary Neoplasms, AnimalMiceMice, Inbred BALB CMicroscopy, FluorescenceMicrotubulesMolecular Sequence DataOpen Reading FramesPhosphoric Monoester HydrolasesPrecipitin TestsProtein Structure, TertiaryRNA, MessengerTransfectionTumor Cells, CulturedConceptsN-terminal BTB domainMouse mammary epithelial cellsPlacental-specific genesMammary epithelial cellsKb ORFBTB domainKelch familyProtein bindsActin filamentsEndoplasmic reticulumMouse mammary tumorsBreast cell linesHuman breast cell linesExtracellular matrixProteinCell linesEpithelial cellsMalignant progressionTranscriptsCellular structureMicrofilamentsActinGrowth rateMammary tumorsExpression