2020
Synovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report.
Munger AM, Ibe IK, Rottmann D, Conway D, Costa J, Lindskog DM. Synovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report. JBJS Case Connector 2020, 10: e0490. PMID: 32224675, DOI: 10.2106/jbjs.cc.19.00490.Peer-Reviewed Case Reports and Technical NotesConceptsSynovial myxomaCase reportRight knee painYear old womanCluster of differentiationLow proliferative activityAggressive massKnee painPathologic reviewIntralesional resectionArthroscopic synovectomyKnee aspirationSynovial cellsInfiltrative tumorsMyxoid stromaProliferative activityPainSynovectomyMyxomaSlow growingReportResectionPatientsEffusionHumans
2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
2002
p53 Mutations as Tumor Markers in Fine Needle Aspirates of Palpable Breast Masses
Dillon DA, Hipolito E, Zheng K, Rimm DL, Costa JC. p53 Mutations as Tumor Markers in Fine Needle Aspirates of Palpable Breast Masses. Acta Cytologica 2002, 46: 841-847. PMID: 12365217, DOI: 10.1159/000327057.Peer-Reviewed Original ResearchMeSH KeywordsAbscessAdenocarcinomaAdultAgedAged, 80 and overAmino Acid SubstitutionBiomarkers, TumorBiopsy, NeedleBreast NeoplasmsCarcinoma, Ductal, BreastCodon, TerminatorCystsDNA Mutational AnalysisDNA, NeoplasmExonsFemaleFrameshift MutationGenes, p53GenotypeHumansMiddle AgedMutationPolymorphism, Single-Stranded ConformationalRetrospective StudiesConceptsFine needle aspiratesP53 exons 5Breast massesPolymerase chain reactionNeedle aspiratesP53 mutationsSingle-strand conformational polymorphism analysisSubsequent excisional biopsyPalpable breast massesPotential diagnostic utilityDefinitive cytologic diagnosisTumor cell markersExon 5Molecular diagnostic markersExcisional biopsyBenign cytologyBreast carcinomaSuspicious cytologyRetrospective analysisCytologic diagnosisTumor markersDiagnostic criteriaBiopsy tissueMorphologic diagnosisDiagnostic utility
1999
Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms
Couce M, Bautista D, Costa J, Carter D. Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms. Applied Immunohistochemistry & Molecular Morphology 1999, 8: 71-79. PMID: 10475381, DOI: 10.1097/00019606-199906000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesDNA Mutational AnalysisExonsFemaleGenes, rasHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedMutation, MissenseNeuroendocrine TumorsPoint MutationPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalRetrospective StudiesTumor Suppressor Protein p53ConceptsLarge cell neuroendocrine carcinomaPulmonary neuroendocrine tumorsAtypical carcinoidNeuroendocrine tumorsTypical carcinoidP53 geneK-rasCell neuroendocrine carcinomaSingle-strand conformation polymorphismHigh-grade tumorsHigh-grade carcinomaH-ras mutationsLung neuroendocrine neoplasmsN-rasK-ras mutationsH-RasExon 5Neuroendocrine carcinomaPolymerase chain reactionNeuroendocrine neoplasmsPositive immunostainingGenotypic mutationsN-ras geneTumors
1998
The Molecular Biology of Breast Cancer: Accelerating Clinical Applications
Dillon D, Howe C, Bosari S, Costa J. The Molecular Biology of Breast Cancer: Accelerating Clinical Applications. Critical Reviews™ In Oncogenesis 1998, 9: 125-140. PMID: 9973246, DOI: 10.1615/critrevoncog.v9.i2.30.Peer-Reviewed Original ResearchConceptsBreast cancerClinical applicationPreclinical disease modelsRegional oncology networkMolecular eventsOncology NetworkPractice guidelinesBRCA-1BRCA-2CancerGrowth factorTranslational researchDisease modelsPathogenesisCell deathBasic scienceCell cycle controlMetastasisClinicTherapyCycle controlMolecular biologyAbnormalitiesDiagnosis
1996
Identification of mutations in the Ki-ras gene in human retinoblastoma.
Bautista D, Emanuel J, Granville C, Howard R, Costa J. Identification of mutations in the Ki-ras gene in human retinoblastoma. Investigative Ophthalmology & Visual Science 1996, 37: 2313-7. PMID: 8843915.Peer-Reviewed Original ResearchConceptsKi-ras geneKi-rasIdentification of mutationsSelective growth advantageGenomic sequencesSingle-strand conformation polymorphismGrowth advantageTumor cell populationGenesExon 1Ki-ras mutationsMutationsExon 2Cell populationsConformation polymorphismHuman retinoblastomaClonal mutationsDirect sequencingPolymerase chain reactionTumor samplesLight microscopyMutational statusChain reactionRetinoblastomaOncogeneDetection of rare circulating human colon tumor cells in a nude mouse xenograft model
Pages J, Sordat B, Bautista D, Costa J, Benhattar J. Detection of rare circulating human colon tumor cells in a nude mouse xenograft model. Cancer Letters 1996, 106: 139-144. PMID: 8827058, DOI: 10.1016/0304-3835(96)04319-4.Peer-Reviewed Original ResearchConceptsHuman colon tumor cellsTumor cellsColon tumor cellsSensitive allele-specific polymerase chain reactionExperimental modelNude mouse xenograft modelK-ras mutationsMouse xenograft modelAllele-specific polymerase chain reactionK-ras geneLymph nodesPrimary implantationSpecific polymerase chain reactionHuman colon carcinoma cellsMicrometastatic depositsPolymerase chain reactionColon carcinoma cellsXenograft modelNude miceGAT mutationMetastatic processCarcinoma cellsBloodChain reactionOccurrence of cellsAngiotropic large cell lymphoma presenting as primary adrenal insufficiency
Chu P, Costa J, Lachman M. Angiotropic large cell lymphoma presenting as primary adrenal insufficiency. Human Pathology 1996, 27: 209-211. PMID: 8617467, DOI: 10.1016/s0046-8177(96)90379-2.Peer-Reviewed Original ResearchConceptsPrimary adrenal insufficiencyLarge cell lymphomaAdrenal insufficiencyCell lymphomaAngiotropic large cell lymphomaSevere metabolic acidosisNeoplastic lymphoid cellsB-cell lineageLymphoma PresentingUnexplained hypotensionMultiorgan involvementUnrecognized causeAdrenal glandMetabolic acidosisCortical vesselsHormone deficiencyDifferential diagnosisLymphoid cellsParenchymal cellsPatientsLymphomaInsufficiencyHypotensionCellsPresenting
1994
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. American Journal Of Pathology 1994, 144: 767-75. PMID: 8160776, PMCID: PMC1887244.Peer-Reviewed Original ResearchConceptsK-ras mutationsLongstanding ulcerative colitisUlcerative colitisP53 alterationsActive colitisDysplastic lesionsK-rasGenetic alterationsP53 gene alterationsP53 genetic alterationsCombination of immunohistochemistryK-ras geneNonneoplastic lesionsColorectal carcinomaInvasive carcinomaColonic carcinomaDysplastic mucosaEpithelial lesionsInvasive tumorsColitisSame patientCarcinomaSporadic carcinomasLesionsNontumor samplesPapillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study
Guillou L, De Luze P, Zysset F, Costa J. Papillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study. American Journal Of Clinical Pathology 1994, 101: 269-274. PMID: 8135181, DOI: 10.1093/ajcp/101.3.269.Peer-Reviewed Original ResearchConceptsLow-grade mucoepidermoid carcinomaMucoepidermoid carcinomaPapillary variantLow malignant potentialBronchial mucous gland adenomaElectron microscopic featuresMucous gland adenomaAppropriate therapyLower lobePapillary tumorsMalignant potentialImmunohistochemical studyDifferential diagnosisPostmortem examinationBronchial neoplasmsGland adenomaSurface epitheliumNeoplasm categoryLight microscopicCarcinomaMicroscopic featuresLesionsTumorsLobectomyPapillomas
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1991
Alveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case
Guillou L, Lamoureux E, Masse S, Costa J. Alveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case. Virchows Archiv A Pathological Anatomy And Histopathology 1991, 418: 467-471. PMID: 2035261, DOI: 10.1007/bf01605935.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaSoft part sarcomaUterine corpusHMB-45 antibodyEvidence of diseaseNK1/C3Hysterectomy specimenClinical managementIncidental findingDifferential diagnosisElectron microscopic examinationTumor cellsSarcomaMicroscopic examinationCytoplasmic granulesUltrastructural studyPatientsImmunoreactivityCytokeratinCrystalloidsDiseaseDiagnosisVimentinDesminAntibodies
1989
Post-Operative Pseudosarcoma of the Vagina A Case Report
Guillou L, Gloor E, De Grandi P, Costa J. Post-Operative Pseudosarcoma of the Vagina A Case Report. Pathology - Research And Practice 1989, 185: 245-248. PMID: 2678035, DOI: 10.1016/s0344-0338(89)80261-4.Peer-Reviewed Original ResearchIdiopathic Entero-colic Lymphocytic Phlebitis
Saraga E, Costa J. Idiopathic Entero-colic Lymphocytic Phlebitis. The American Journal Of Surgical Pathology 1989, 13: 303-308. PMID: 2929846, DOI: 10.1097/00000478-198904000-00005.Peer-Reviewed Original ResearchConceptsLymphocytic phlebitisIntestinal ischemic necrosisSystemic vasculitisLymphocytic infiltrateClinicopathological entityIschemic necrosisSurgical specimensExtensive lesionsHistological examinationB lymphocytesLaboratory evidencePhlebitisPatientsDifferent agesVasculitisReoperationInfiltratesThrombosisArteryRecurrenceArteriolesEtiologyLesionsNecrosisMonthsPostoperative pseudosarcomas of the genitourinary tract. A diagnostic trap. Presentation of 4 cases of which 2 were studied immunohistochemically and review of the literature.
Guillou L, Costa J. Postoperative pseudosarcomas of the genitourinary tract. A diagnostic trap. Presentation of 4 cases of which 2 were studied immunohistochemically and review of the literature. Annales De Pathologie 1989, 9: 340-5. PMID: 2692574.Peer-Reviewed Original ResearchConceptsGenitourinary tractCellular spindle cell proliferationYear old womanMetastases 8 monthsSpindle cell proliferationVaginal hysterectomyLocal excisionProstatic adenomectomyImmunohistochemical studyDiagnostic trapAppearance suggestiveNumerous mitosesTransurethral cystoscopyMuscle actinFactor VIIIMonthsStrong reactivityCell proliferationMicroscopic examinationBladderTractWomenSmooth muscle myosinNodulesAdenomectomy
1987
Histopathology of bone marrow in human immunodeficiency virus infXection
Delacrétaz F, Perey L, Schmidt P, Chave J, Costa J. Histopathology of bone marrow in human immunodeficiency virus infXection. Virchows Archiv A Pathological Anatomy And Histopathology 1987, 411: 543-551. PMID: 3118563, DOI: 10.1007/bf00713285.Peer-Reviewed Original ResearchConceptsHIV infectionMyelodysplastic featuresHistological featuresHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBone marrow findingsBone marrow biopsyMarrow findingsMarrow biopsyHaematological abnormalitiesGelatinous transformationVirus infectionHaematological findingsPatientsBone marrowConspicuous findingInfectionCell linesFindingsCytopaeniaPlasmacytosisLymphocytosisBiopsyMyelodysplasiaHypercellularityGastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original ResearchHistopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy
Delacrétaz F, Schmidt P, Piguet D, Bachmann F, Costa J. Histopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy. American Journal Of Clinical Pathology 1987, 87: 180-186. PMID: 3812349, DOI: 10.1093/ajcp/87.2.180.Peer-Reviewed Original ResearchConceptsBone marrow biopsyMyelodysplastic syndromeMarrow biopsyMarrow smearsType of MDSPeripheral blood blastsPercentage of blastsBone marrow aspirationBritish Cooperative GroupBlood blastsFAB classificationMarrow aspirationMonocyte countTrephine biopsyTumor infiltrationCytologic examinationPossible alternative causesFAB groupRing sideroblastsBiopsyMorphologic criteriaAlternative causesImmature precursorsAbnormal localizationCooperative groups
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients