2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
1999
Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms
Couce M, Bautista D, Costa J, Carter D. Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms. Applied Immunohistochemistry & Molecular Morphology 1999, 8: 71-79. PMID: 10475381, DOI: 10.1097/00019606-199906000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesDNA Mutational AnalysisExonsFemaleGenes, rasHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedMutation, MissenseNeuroendocrine TumorsPoint MutationPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalRetrospective StudiesTumor Suppressor Protein p53ConceptsLarge cell neuroendocrine carcinomaPulmonary neuroendocrine tumorsAtypical carcinoidNeuroendocrine tumorsTypical carcinoidP53 geneK-rasCell neuroendocrine carcinomaSingle-strand conformation polymorphismHigh-grade tumorsHigh-grade carcinomaH-ras mutationsLung neuroendocrine neoplasmsN-rasK-ras mutationsH-RasExon 5Neuroendocrine carcinomaPolymerase chain reactionNeuroendocrine neoplasmsPositive immunostainingGenotypic mutationsN-ras geneTumors
1994
Papillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study
Guillou L, De Luze P, Zysset F, Costa J. Papillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study. American Journal Of Clinical Pathology 1994, 101: 269-274. PMID: 8135181, DOI: 10.1093/ajcp/101.3.269.Peer-Reviewed Original ResearchConceptsLow-grade mucoepidermoid carcinomaMucoepidermoid carcinomaPapillary variantLow malignant potentialBronchial mucous gland adenomaElectron microscopic featuresMucous gland adenomaAppropriate therapyLower lobePapillary tumorsMalignant potentialImmunohistochemical studyDifferential diagnosisPostmortem examinationBronchial neoplasmsGland adenomaSurface epitheliumNeoplasm categoryLight microscopicCarcinomaMicroscopic featuresLesionsTumorsLobectomyPapillomas
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1988
Interdisciplinary detection of soft tissue sarcomas. Diagnosis, grading and staging.
Leyvraz S, Costa J. Interdisciplinary detection of soft tissue sarcomas. Diagnosis, grading and staging. Die Orthopädie 1988, 17: 121-7. PMID: 3290794.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasTissue sarcomasDifferent prognostic factorsManagement of patientsStratification of patientsPrognostic factorsSimilar prognosisSurgical marginsHistological diagnosisStaging systemClinical aspectsOptimal diagnosisTumorsPatientsDiagnosisPrognosisSarcomaStagingCliniciansPathologistsGrading
1987
Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma
Monnat M, Tardy S, Saraga P, Diggelmann H, Costa J. Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma. International Journal Of Cancer 1987, 40: 293-299. PMID: 3040597, DOI: 10.1002/ijc.2910400302.Peer-Reviewed Original Research
1985
Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
Knazek R, Yee C, Costa J. Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors. International Journal Of Cancer 1985, 36: 143-152. PMID: 2991146, DOI: 10.1002/ijc.2910360204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidArachidonic AcidsChondrosarcomaChromatography, High Pressure LiquidChromatography, Thin LayerHistiocytoma, Benign FibrousHumansHydroxyeicosatetraenoic AcidsMiceMice, NudeNeoplasm TransplantationProstaglandinsRadioimmunoassayRhabdomyosarcomaSarcomaSarcoma, SynovialSoft Tissue NeoplasmsTeratomaConceptsArachidonic acid metabolitesAcid metabolitesSynovial cell sarcomaSame histological typeMalignant fibrous histiocytomaTotal prostaglandin synthesisHydroxyeicosatetraenoic acid synthesisHuman mesenchymal tumorsMesenchymal tumor cellsHistological typeMesenchymal tumorsPGF2 alphaFibrous histiocytomaThromboxane A2Embryonal carcinomaNude miceProstaglandin synthesisPGE2 synthesisTransplantable tumorsAlveolar rhabdomyosarcomaTumorsStromal cellsArachidonic acidNormal tissuesTumor cells
1983
Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice2
Tralka T, Yee C, Rabson A, Wivel N, Stromberg K, Rabson A, Costa J. Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice2. Journal Of The National Cancer Institute 1983, 71: 591-599. PMID: 6310201, DOI: 10.1093/jnci/71.3.591.Peer-Reviewed Original ResearchConceptsType C virus particlesC virus particlesHuman osteosarcoma cellsNude miceHuman tumorsType C virus productionC virus infectionOsteosarcoma cellsStromal cell componentsVirus particlesType C virusesMurine type C retrovirusesC virusHLA determinantsVirus infectionHuman tumor cellsEmbryonal carcinomaType C retrovirusesHuman cellsNucleic acid hybridization studiesTumor cellsMurine leukemia virusTumorsVirus productionMice
1982
Small‐cell osteosarcoma
Martin S, Dwyer A, Kissane J, Costa J. Small‐cell osteosarcoma. Cancer 1982, 50: 990-996. PMID: 6953993, DOI: 10.1002/1097-0142(19820901)50:5<990::aid-cncr2820500529>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsSmall cell osteosarcomaAdjuvant chemotherapyEwing's sarcomaEvidence of diseaseSymptoms of painForms of osteosarcomaClinical featuresOptimal therapyMonths durationRadiographic appearanceSarcomaTumorsRound cellsPatientsOsteoid matrixOsteosarcomaChemotherapyReceived radiationWide variationPainSurgeryTherapyLesionsSymptomsIncidenceUnusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor
Tralka T, Yee C, Triche T, Costa J, Dienes H. Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor. Ultrastructural Pathology 1982, 3: 161-167. PMID: 6285572, DOI: 10.3109/01913128209016640.Peer-Reviewed Original Research
1978
Osteosarcoma associated with thorotrast administration. Report of two cases and literature review
Sindelar W, Costa J, Ketcham A. Osteosarcoma associated with thorotrast administration. Report of two cases and literature review. Cancer 1978, 42: 2604-2609. PMID: 365315, DOI: 10.1002/1097-0142(197812)42:6<2604::aid-cncr2820420615>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsCases of osteosarcomaPathologic evidencePrimary tumorThorotrast depositsPossible causal relationshipReticuloendothelial systemOsteosarcomaPrevious casesChronic radiationPatientsNeoplastic transformationAdministrationBoneLiterature reviewAngiographyCausal relationshipHistologyTumorsThorotrastCases
1977
Oncogenicity of a Nude Mouse Cell Line Transformed by a Human Papovavirus
Costa J, Howley P, Legallais F, Yee C, Young N, Rabson A. Oncogenicity of a Nude Mouse Cell Line Transformed by a Human Papovavirus. Journal Of The National Cancer Institute 1977, 58: 1147-1149. PMID: 557569, DOI: 10.1093/jnci/58.4.1147.Peer-Reviewed Original ResearchSpontaneous Lymphosarcoma Arising in a Nude Mouse: Characterization In Vivo and In Vitro
Tralka T, Costa J, Sindelar W, Rabson A, Gullino P, Henson E, Chu E, O'Conor G. Spontaneous Lymphosarcoma Arising in a Nude Mouse: Characterization In Vivo and In Vitro. Journal Of The National Cancer Institute 1977, 58: 977-982. PMID: 191631, DOI: 10.1093/jnci/58.4.977.Peer-Reviewed Original Research
1976
Hamster Ependymomas Produced by Intracerebral Inoculation of a Human Papovavirus (MMV)
Costa J, Yee C, Tralka T, Rabson A. Hamster Ependymomas Produced by Intracerebral Inoculation of a Human Papovavirus (MMV). Journal Of The National Cancer Institute 1976, 56: 863-864. PMID: 176415, DOI: 10.1093/jnci/56.4.863.Peer-Reviewed Original Research