2024
Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair
Seddio A, Moran J, Gouzoulis M, Garbis N, Salazar D, Grauer J, Jimenez A. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024 PMID: 39490542, DOI: 10.1016/j.arthro.2024.09.057.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairT2DM patientsRotator cuff retearRotator cuff repairElixhauser Comorbidity IndexAdverse eventsLow risk of postoperative complicationsOdds ratioRisk of postoperative complicationsKaplan-Meier survival analysisUrinary tract infectionSurgical-site infectionCuff repairLog-rank testRetrospective comparative studyAcute kidney injuryMinor adverse eventsType II diabetes mellitusAssociated with decreased oddsMultivariate logistic regressionArthroscopic shoulder proceduresII diabetes mellitusAdministrative billing codesPostoperative complicationsTract infectionsComparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients.
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Vasudevan R, Day W, Ratnasamy P, Rubio D, Grauer J. Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients. Spine 2024 PMID: 39394649, DOI: 10.1097/brs.0000000000005181.Peer-Reviewed Original ResearchNeurological adverse eventsAdverse eventsElixhauser Comorbidity IndexNeurological complicationsOdds ratioEpidural spinal injectionsInterlaminar (ILTransforaminal epidural injectionsAssociated with specific complicationsTransforaminal (TFNerve root injuryRisk of complicationsAssociated with higher odds ratiosMultivariate logistic regressionRisk of neurological adverse eventsHigher odds ratioCervical pathologyEpidural hematomaTF injectionSpinal injectionEpidural injectionSpecific complicationsAdult patientsCase reportComorbidity indexGoldenhar syndrome associated with increased risk of respiratory failure and reoperations following spinal deformity surgery
Gouzoulis M, Jabbouri S, Seddio A, Grauer J, Tuason D. Goldenhar syndrome associated with increased risk of respiratory failure and reoperations following spinal deformity surgery. Spine Deformity 2024, 1-6. PMID: 39249241, DOI: 10.1007/s43390-024-00963-3.Peer-Reviewed Original ResearchAdolescent idiopathic scoliosisPosterior spinal fusionGoldenhar syndromeAdverse eventsRespiratory failureSpinal fusionDeformity surgeryIncreasing odds of respiratory failureOdds ratioRisk of respiratory failureOdds of respiratory failureIncidence of adverse eventsIncidence of reoperationSpinal deformity surgeryRisk of adverse eventsSevere adverse eventsPostoperative adverse eventsMultivariate logistic regressionAssociated with scoliosisNational sample of patientsSample of patientsBackgroundGoldenhar syndromeSpinal manifestationsElixhauser Comorbidity IndexPearlDiver databaseP27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisP31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse eventsOne- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions.
Ratnasamy P, Gouzoulis M, Jabbouri S, Rubio D, Grauer J. One- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions. Spine 2024 PMID: 39190416, DOI: 10.1097/brs.0000000000005130.Peer-Reviewed Original ResearchOne-level fusionLumbar decompressionThree-level fusionPostoperative adverse eventsAdverse eventsOdds ratioElixhauser Comorbidity IndexPatient ageFive-year survivalOdds of perioperative complicationsLumbar decompression patientsPerioperative complicationsDecompression patientsPerioperative riskFusion patientsSpinal reoperationLumbar fusionReoperationComorbidity indexMultivariate analysisPatientsClinical interestDecompressionFusion levelsOddsRate and risk factors for inpatient falls following single-level posterior lumbar fusion: A national registry study
Gouzoulis M, Jabbouri S, Seddio A, Moran J, Day W, Ratnasamy P, Grauer J. Rate and risk factors for inpatient falls following single-level posterior lumbar fusion: A national registry study. North American Spine Society Journal (NASSJ) 2024, 20: 100549. PMID: 39318705, PMCID: PMC11417567, DOI: 10.1016/j.xnsj.2024.100549.Peer-Reviewed Original ResearchPosterior lumbar fusionSingle-level posterior lumbar fusionInpatient fallsOdds ratioLumbar fusionFall prevention programsIncidence of secondary injuryNational sample of patientsRisk factorsDecreased odds ratioPatient variablesPotential patient outcomesMultivariate logistic regressionNational registry studySample of patientsPrevention programsInpatient costsMedicaid insuranceActive deliriumAlcohol use disorderMethods Adult patientsSpinal pathologyOutcome metricsCommercial insuranceNational sampleRisk Factors for Perioperative Nerve Injury Related to Total Hip Arthroplasty
Jayaram R, Day W, Gouzoulis M, Zhu J, Grauer J, Rubin L. Risk Factors for Perioperative Nerve Injury Related to Total Hip Arthroplasty. Arthroplasty Today 2024, 28: 101440. PMID: 39139361, PMCID: PMC11320433, DOI: 10.1016/j.artd.2024.101440.Peer-Reviewed Original ResearchBody mass indexNerve injuryElixhauser Comorbidity IndexRisk factorsMultivariate analysisOdds ratioRisk of nerve injuryTotal hip arthroplastyRevision proceduresObese BMI statusUnderweight body mass indexDecreased odds ratioPatient ageSurgery typeRisk stratificationAdverse eventsBMI statusMass indexFemale sexAdverse outcomesComorbidity indexDecreased riskPatient counselingHip arthroplastyNerveIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infectionsTotal shoulder arthroplasty in patients with Factor V Leiden
Zehner K, Sanchez J, Dhodapkar M, Modrak M, Luo X, Grauer J. Total shoulder arthroplasty in patients with Factor V Leiden. Journal Of Shoulder And Elbow Surgery 2024 PMID: 38479723, DOI: 10.1016/j.jse.2024.01.041.Peer-Reviewed Original ResearchFactor V LeidenVenous thromboembolismAdverse eventsV LeidenTSA patientsRevision rateProphylactic agentFactor V Leiden patientsVTE prophylactic agentOdds ratioRisk of venous thromboembolismEffective treatment optionOdds of bleeding complicationsDeep vein thrombosisMultivariate logistic regressionEnd-stage glenohumeral osteoarthritisTotal shoulder arthroplastyInherited thrombophiliaBleeding complicationsElixhauser Comorbidity IndexLonger-term outcomesPulmonary embolismProthrombotic stateVein thrombosisAdult patientsPhysical Therapy Utilization After Single-level Posterior Lumbar Fusion
Gouzoulis M, Moran J, Jeong S, Galivanche A, Kammien A, Jabbouri S, Grauer J. Physical Therapy Utilization After Single-level Posterior Lumbar Fusion. Spine 2024, 49: e272-e278. PMID: 38349019, DOI: 10.1097/brs.0000000000004958.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionPhysical therapyOdds ratioLumbar fusionPhysical therapy utilizationFemale sexLevel posterior lumbar fusionsReturn to activityDecreased odds ratioOutpatient therapyPredictors of therapyTiming of therapyMinority of patientsOutpatient PTNonmedical factorsAdministrative databasesMedicaid insuranceTherapy utilizationPractice patternsCommercial insuranceInsurance plansPatient characteristicsSurgeryTherapyAdverse Events After Isolated Posterior Cruciate Ligament Reconstruction: A National Database Study
Kammien A, Price R, McLaughlin W, Park N, Richter D, Schenck R, Grauer J, Medvecky M. Adverse Events After Isolated Posterior Cruciate Ligament Reconstruction: A National Database Study. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671231222123. PMID: 38249782, PMCID: PMC10798085, DOI: 10.1177/23259671231222123.Peer-Reviewed Original ResearchRate of adverse eventsSurgical site infectionIsolated PCL reconstructionAdverse eventsPCL reconstructionPulmonary embolismSite infectionCompartment syndromePosterior cruciate ligamentVariable rates of complicationsOdds ratioVascular eventsOptimal managementIsolated posterior cruciate ligament reconstructionConcomitant ligament surgeryEmergency departmentNational cohortDeep vein thrombosesRate of complicationsElixhauser Comorbidity Index scoreDay of surgeryDeep vein thrombosisCalculate odds ratiosPosterior cruciate ligament reconstructionComorbidity Index score
2023
Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease
Dhodapkar M, Halperin S, Saifi C, Whang P, Grauer J, Varthi A. Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease. The Spine Journal 2023, 24: 807-811. PMID: 38081460, DOI: 10.1016/j.spinee.2023.11.025.Peer-Reviewed Original ResearchPosterior lumbar interbody fusionSingle-level posterior lumbar interbody fusionSickle cell diseaseElixhauser Comorbidity IndexAdverse eventsPostoperative outcomesInterbody fusionOdds ratioCell diseaseDays adverse eventsMinor adverse eventsPostoperative adverse eventsPerioperative adverse eventsSevere adverse eventsCohort of patientsED visit ratesEmergency department visitsMultivariable logistic regressionNational administrative databaseRetrospective database studyLumbar interbody fusionSingle level posteriorComorbidity indexPLIF patientsAdult patientsSingle-level Anterior Cervical Discectomy and Fusion Results in Lower Five-year Revisions than Posterior Cervical Foraminotomy in a Large National Cohort
Jayaram R, Joo P, Gouzoulis M, Ratnasamy P, Caruana D, Grauer J. Single-level Anterior Cervical Discectomy and Fusion Results in Lower Five-year Revisions than Posterior Cervical Foraminotomy in a Large National Cohort. Spine 2023, 48: 1266-1271. PMID: 37339256, DOI: 10.1097/brs.0000000000004754.Peer-Reviewed Original ResearchConceptsPosterior cervical foraminotomySingle-level ACDFSingle-level anterior cervical discectomyPerioperative adverse eventsAnterior cervical discectomyAdverse eventsCervical foraminotomyCervical discectomyRevision rateOdds ratioShort-term adverse eventsSimilar short-term outcomesKaplan-Meier survival analysisRetrospective cohort studySerious adverse eventsCervical disc diseaseFive-year ratesSurgical site infectionShort-term outcomesMultivariable logistic regressionLarge national cohortCumulative revision rateCervical reoperationPCF cohortCohort studyUrgent Care Versus Emergency Department Utilization for Foot and Ankle Fractures
Dhodapkar M, Gouzoulis M, Halperin S, Modrak M, Yoo B, Grauer J. Urgent Care Versus Emergency Department Utilization for Foot and Ankle Fractures. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 984-989. PMID: 37253245, DOI: 10.5435/jaaos-d-22-01097.Peer-Reviewed Original ResearchConceptsUrgent care facilityAnkle fracturesEmergency departmentED utilizationCare facilitiesUrgent careOdds ratioICD-10 diagnosis codesCertain injury typesUrgent care utilizationRetrospective cohort studyUrgent care visitsYears old presentingMinority of patientsEmergency department utilizationOld presentingCare visitsAdult patientsCare algorithmCohort studyIndependent predictorsCare utilizationMultivariable analysisCommon injuriesDiagnosis codes
2022
Comparing Venous Thromboembolism Prophylactic Agents After Hip Fracture Surgery: A National Database Study
Joo P, Modrak M, Park N, Brand J, Rubin L, Grauer J, Bernstein J. Comparing Venous Thromboembolism Prophylactic Agents After Hip Fracture Surgery: A National Database Study. JAAOS Global Research And Reviews 2022, 6: e22.00228. PMID: 36732301, PMCID: PMC9746777, DOI: 10.5435/jaaosglobal-d-22-00228.Peer-Reviewed Original ResearchConceptsHip fracture surgeryFracture surgeryAdverse eventsOdds ratioProphylactic agentGreater oddsAnticoagulant-naïve patientsDifferent anticoagulant agentsVenous thromboembolism chemoprophylaxisVTE prophylactic agentNational database studyDistal femoral fracturesCoumadin groupLower transfusionVTE prophylaxisVTE ratesPatient characteristicsComorbidity profilesFemoral fracturesChemoprophylactic agentAnticoagulant agentsCoumadinDatabase studyLower oddsPatientsPredictors of Physical Abuse in Elder Patients With Fracture
Gardezi M, Moore HG, Rubin LE, Grauer JN. Predictors of Physical Abuse in Elder Patients With Fracture. JAAOS Global Research And Reviews 2022, 6: e22.00144. PMID: 35819835, PMCID: PMC9278940, DOI: 10.5435/jaaosglobal-d-22-00144.Peer-Reviewed Original ResearchConceptsAbuse patientsNational Emergency Department Sample databasePhysical abuseHigh-risk patientsMultivariate regressionPublic health issueLowest income quartileElderly patientsFracture patientsRisk patientsAnkle fracturesIndependent predictorsPediatric populationElder patientsEmergency departmentRib fracturesVolume depletionOdds ratioElder physical abuseElder abusePatientsUnivariate comparisonsMental disordersIncome quartileHealth issuesMarfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery
Joo PY, Caruana DL, Gouzoulis MJ, Moore HG, Zhu JR, Ameri B, Grauer JN. Marfan syndrome and adolescent idiopathic scoliosis patients have similar 90-day postoperative outcomes and 5-year reoperation rates after spinal deformity surgery. Spine Deformity 2022, 10: 1169-1174. PMID: 35362940, DOI: 10.1007/s43390-022-00501-z.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisMarfan syndromeReoperation rateAIS patientsOdds ratioMFS patientsFive-Year Reoperation RatesNinety-day outcomesMinor adverse eventsMultivariate odds ratiosPosterior spinal fusionSpinal deformity surgeryComorbidity indexAdverse eventsDeformity surgeryAdministrative databasesRelative riskSpinal fusionIdiopathic scoliosisPatientsRepresentative sampleAgeOutcomesSexReadmissionFour-level anterior versus posterior cervical fusions: Perioperative outcomes and five-year reoperation rates Outcomes after four-level anterior versus posterior cervical procedures
Joo PY, Jayaram RH, McLaughlin WM, Ameri B, Kammien AJ, Arnold PM, Grauer JN. Four-level anterior versus posterior cervical fusions: Perioperative outcomes and five-year reoperation rates Outcomes after four-level anterior versus posterior cervical procedures. North American Spine Society Journal (NASSJ) 2022, 10: 100115. PMID: 35392022, PMCID: PMC8980614, DOI: 10.1016/j.xnsj.2022.100115.Peer-Reviewed Original ResearchPosterior cervical fusionFour-level ACDFAdverse eventsReoperation rateCervical fusionOdds ratioMinor adverse eventsMultilevel cervical pathologyPosterior cervical proceduresRate of dysphagiaFive-year incidencePerioperative adverse eventsAnterior cervical discectomyHigher reoperation rateLength of stayGreater odds ratioRisk/benefit considerationsPosterior approach proceduresTimes lower oddsCervical reoperationCervical proceduresCervical discectomyPerioperative outcomesPosterior proceduresACDF cases
2018
Thromboembolic Events After Traumatic Vertebral Fractures
Samuel AM, Diaz-Collado PJ, Gala RJ, Webb ML, Lukasiewicz AM, Basques BA, Bohl DD, Kim HJ, Grauer JN. Thromboembolic Events After Traumatic Vertebral Fractures. Spine 2018, 43: 1289-1295. PMID: 29538240, DOI: 10.1097/brs.0000000000002634.Peer-Reviewed Original ResearchConceptsVenous thromboembolism eventsTraumatic vertebral fracturesVertebral fracturesSpinal cord injuryOdds ratioCord injuryRisk factorsNational Trauma Data Bank Research Data SetLonger inpatient lengthPulmonary embolism eventsDeep vein thrombosisHigh-energy injuriesVertebral fracture patientsLength of stayAdditional risk factorsMultivariate logistic regressionSuch adverse outcomesOverall rateThromboembolism eventsHospital courseThromboembolic eventsFracture patientsVein thrombosisLonger LOSTrauma patients