Featured Publications
Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Ramlawi B, Gleason TG, Meduri CU, Yakubov SJ, Jilaihawi H, Liu F, Reardon MJ. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 1749-1759. PMID: 32473890, DOI: 10.1016/j.jcin.2020.03.022.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBicuspid Aortic Valve DiseaseFemaleHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsAortic valve stenosisBicuspid aortic valve stenosisTranscatheter aortic valve replacementEvolut PRO valveAortic valve replacementValve stenosisTVT RegistryCause mortalityValve replacementEvolut RBicuspid valveBicuspid Versus Tricuspid Aortic ValvesSTS/ACC TVT RegistryThoracic Surgeons/American CollegeTricuspid aortic valve stenosisCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisRate of strokeSelf-expanding valvesLow complication rateTricuspid aortic valveAcceptable safety outcomesCardiac comorbiditiesEchocardiographic outcomesAortic stenosis
2024
3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study
Zahr F, Ramlawi B, Reardon M, Deeb G, Yakubov S, Song H, Kleiman N, Chetcuti S, Gada H, Mumtaz M, Leung S, Merhi W, Rovin J, DeFrain M, Muppala M, Kauten J, Rajagopal V, Huang J, Ito S, Forrest J. 3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study. JACC Cardiovascular Interventions 2024, 17: 1667-1675. PMID: 39048253, DOI: 10.1016/j.jcin.2024.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBioprosthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProsthesis DesignRecovery of FunctionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementRates of all-cause mortalityAll-cause mortalityAortic stenosisThoracic Surgeons Predicted Risk of Mortality scoreThoracic Surgeons Predicted RiskSevere paravalvular aortic regurgitationBicuspid aortic valve anatomyRisk of Mortality scoreEchocardiographic core laboratoryLow-surgical risk patientsAortic valve anatomyKaplan-Meier ratesLow surgical riskClinical events committeeAortic valve replacementSevere aortic stenosisParavalvular aortic regurgitationPermanent pacemaker implantationBicuspid aortic stenosisFavorable hemodynamic performanceEvaluated 3 yearsAttempted implantEchocardiographic outcomesAortic regurgitation
2017
1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses
Deeb GM, Chetcuti SJ, Reardon MJ, Patel HJ, Grossman PM, Schreiber T, Forrest JK, Bajwa TK, O’Hair D, Petrossian G, Robinson N, Katz S, Hartman A, Dauerman HL, Schmoker J, Khabbaz K, Watson DR, Yakubov SJ, Oh JK, Li S, Kleiman NS, Adams DH, Popma JJ. 1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses. JACC Cardiovascular Interventions 2017, 10: 1034-1044. PMID: 28521921, DOI: 10.1016/j.jcin.2017.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve InsufficiencyAortic Valve StenosisEchocardiographyFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansKaplan-Meier EstimateMaleMiddle AgedProspective StudiesProsthesis FailureQuality of LifeRecovery of FunctionRecurrenceReoperationRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSelf-expanding transcatheter aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementMajor stroke rateAortic regurgitationValve replacementStroke rateValve hemodynamicsSevere native aortic valve stenosisSuccessful transcatheter aortic valve replacementNative aortic valve stenosisNew permanent pacemaker implantationSevere residual aortic regurgitationValve prosthesis-patient mismatchMean aortic gradientMean valve gradientResidual aortic regurgitationSevere aortic regurgitationProsthesis-patient mismatchCause mortality ratesIndependent core laboratoryModerate aortic regurgitationPermanent pacemaker implantationAortic valve stenosisAortic valve hemodynamics
2016
Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006–2011)
Arora S, Panaich SS, Patel N, Patel NJ, Lahewala S, Thakkar B, Savani C, Jhamnani S, Singh V, Patel N, Patel S, Sonani R, Patel A, Tripathi B, Deshmukh A, Chothani A, Patel J, Bhatt P, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Mena CI, Schreiber T, Grines C, Cleman M, Forrest JK, Badheka AO. Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006–2011). Catheterization And Cardiovascular Interventions 2016, 88: 605-616. PMID: 26914274, DOI: 10.1002/ccd.26452.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalCross-Sectional StudiesDatabases, FactualDrug CostsEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansLimb SalvageLogistic ModelsLower ExtremityMaleMiddle AgedMultivariate AnalysisOdds RatioPeripheral Arterial DiseasePlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexPropensity ScoreRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsGlycoprotein IIb/IIIa inhibitorsPeripheral endovascular interventionsHospital mortalityHospitalization costsEndovascular interventionGPI useAmputation rateUtilization Project Nationwide Inpatient Sample databaseTwo-level hierarchical multivariateIIb/IIIa inhibitorsNationwide Inpatient Sample databaseLower amputation ratesPaucity of dataHospital outcomesPostprocedural complicationsSecondary outcomesPropensity matchingStudy cohortHealthcare costsICD-9Multivariate analysisStudy outcomesSample databaseMortalityHierarchical multivariate
2015
Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis
Thakkar B, Patel A, Mohamad B, Patel NJ, Bhatt P, Bhimani R, Patel A, Arora S, Savani C, Solanki S, Sonani R, Patel S, Patel N, Deshmukh A, Mohamad T, Grines C, Cleman M, Mangi A, Forrest J, Badheka AO. Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis. Catheterization And Cardiovascular Interventions 2015, 87: 955-962. PMID: 26699085, DOI: 10.1002/ccd.26345.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBlood TransfusionCardiac CatheterizationChi-Square DistributionCross-Sectional StudiesDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital CostsHumansLength of StayLiver CirrhosisLogistic ModelsMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsPropensity ScoreRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementValve replacementNational Inpatient SampleCirrhosis patientsTAVR groupComplication rateICD-9-CM diagnosis codesICD-9-CM procedureHospital mortality rateSevere aortic stenosisHigh-risk patientsOpen heart surgeryYears of agePostprocedural lengthSAVR groupHospital outcomesOperative morbidityPortal hypertensionAortic stenosisCardiac surgeryCardiopulmonary bypassEsophageal varicesLiver cirrhosisIntravascular Ultrasound in Lower Extremity Peripheral Vascular Interventions
Panaich SS, Arora S, Patel N, Patel NJ, Savani C, Patel A, Thakkar B, Singh V, Patel S, Patel N, Agnihotri K, Bhatt P, Deshmukh A, Gupta V, Attaran RR, Mena CI, Grines CL, Cleman M, Forrest JK, Badheka AO. Intravascular Ultrasound in Lower Extremity Peripheral Vascular Interventions. Journal Of Endovascular Therapy 2015, 23: 65-75. PMID: 26637836, DOI: 10.1177/1526602815620780.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalChi-Square DistributionCost-Benefit AnalysisDatabases, FactualEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansLimb SalvageLinear ModelsLower ExtremityMaleMiddle AgedMultivariate AnalysisOdds RatioPeripheral Vascular DiseasesPractice Patterns, Physicians'Risk FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesYoung AdultConceptsLower limb endovascular interventionsPostprocedural complicationsHospitalization costsEndovascular interventionHospital mortalityAmputation rateOdds ratioNonsignificant increaseUtilization Project Nationwide Inpatient Sample databaseTwo-level hierarchical multivariateICD-9 procedure codesNationwide Inpatient Sample databasePeripheral vascular proceduresCo-primary outcomesLower amputation ratesPeripheral vascular interventionsPeripheral endovascular interventionsConfidence intervalsIVUS useIVUS utilizationSecondary outcomesStudy cohortVascular proceduresVascular interventionsHealthcare costsMechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample)
Singh V, Patel SV, Savani C, Patel NJ, Patel N, Arora S, Panaich SS, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample). The American Journal Of Cardiology 2015, 116: 1574-1580. PMID: 26434512, DOI: 10.1016/j.amjcard.2015.08.020.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationMechanical circulatory support devicesAortic valve implantationCirculatory support devicesMCS devicesValve implantationHigh-risk surgical patientsPropensity score-matched analysisClinical Modification procedure codesSupport devicesVentricular fibrillation arrestNationwide Inpatient SampleCost of hospitalizationShort-term useSignificant increaseUnacceptably high ratesInhospital mortalityInhospital outcomesCardiogenic shockIndependent predictorsSurgical patientsNinth RevisionTAVI procedureTransapical accessInpatient SampleComparison of Inhospital Outcomes of Surgical Aortic Valve Replacement in Hospitals With and Without Availability of a Transcatheter Aortic Valve Implantation Program (from a Nationally Representative Database)
Singh V, Badheka AO, Patel SV, Patel NJ, Thakkar B, Patel N, Arora S, Patel N, Patel A, Savani C, Ghatak A, Panaich SS, Jhamnani S, Deshmukh A, Chothani A, Sonani R, Patel A, Bhatt P, Dave A, Bhimani R, Mohamad T, Grines C, Cleman M, Forrest JK, Mangi A. Comparison of Inhospital Outcomes of Surgical Aortic Valve Replacement in Hospitals With and Without Availability of a Transcatheter Aortic Valve Implantation Program (from a Nationally Representative Database). The American Journal Of Cardiology 2015, 116: 1229-1236. PMID: 26297512, DOI: 10.1016/j.amjcard.2015.07.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveBicuspid Aortic Valve DiseaseCardiac Care FacilitiesDatabases, FactualFemaleHeart Defects, CongenitalHeart Valve DiseasesHospital MortalityHospitalizationHumansMaleMiddle AgedPropensity ScoreTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementTranscatheter aortic valve implantation (TAVI) programCo-morbidity scoreAortic valve replacementTAVI programNationwide Inpatient SampleTAVI groupComplication rateInhospital outcomesValve replacementConventional surgical aortic valve replacementCharlson co-morbidity scoreClinical Modification procedure codesLower inhospital mortalityAortic valve diseaseCost of hospitalizationImplantation programYears of ageInhospital mortalitySAVR proceduresHospital stayValve diseaseNinth RevisionMean agePatient populationVaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES
Chothani A, Shah N, Patel NJ, Deshmukh A, Singh V, Patel N, Panaich SS, Arora S, Patel A, Savani C, Thakkar B, Bhatt P, Cohen MG, Grines C, Forrest JK, Badheka AO. Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES. Postgraduate Medicine 2015, 127: 561-564. PMID: 26174358, DOI: 10.1080/00325481.2015.1064300.Peer-Reviewed Original ResearchConceptsCV mortalityVaccination titersContinuous NHANESNHANES IIIProportional hazards regression modelingNutrition Examination Survey IIINon-influenza vaccinesExamination Survey IIINon-institutionalized patientsOverall health statusNHANES III dataSerology statusSeroprotective titersVaccination variablesCardiovascular eventsInfluenza vaccinationCardiovascular mortalityHazard ratioRoutine vaccinationNational HealthProtective effectHealth statusVaccinationReferent groupMortalityMultivessel Percutaneous Coronary Interventions in the United States
Arora S, Panaich SS, Patel NJ, Patel N, Solanki S, Deshmukh A, Singh V, Lahewala S, Savani C, Thakkar B, Dave A, Patel A, Bhatt P, Sonani R, Patel A, Cleman M, Forrest JK, Schreiber T, Badheka AO, Grines C. Multivessel Percutaneous Coronary Interventions in the United States. Angiology 2015, 67: 326-335. PMID: 26145455, DOI: 10.1177/0003319715593853.Peer-Reviewed Original ResearchConceptsMultivessel percutaneous coronary interventionLength of stayNationwide Inpatient SamplePercutaneous coronary interventionInhospital mortalityStent PCICoronary interventionSecondary outcomesHospitalization costsUtilization Project Nationwide Inpatient SampleMultivessel coronary artery diseaseShorter LOSClinical Modification procedure codesHigher inhospital mortalityHigh-volume hospitalsCoronary artery diseaseSignificant mortality riskAcute myocardial infarctionLower hospitalization costsCost of careDifferent International ClassificationInhospital outcomesCause mortalityPeriprocedural complicationsVolume hospitalsImpact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011])
Arora S, Panaich SS, Patel N, Patel N, Lahewala S, Solanki S, Patel P, Patel A, Manvar S, Savani C, Tripathi B, Thakkar B, Jhamnani S, Singh V, Patel S, Patel J, Bhimani R, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest J, Badheka AO. Impact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011]). The American Journal Of Cardiology 2015, 116: 791-800. PMID: 26100585, DOI: 10.1016/j.amjcard.2015.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overEndovascular ProceduresFemaleFollow-Up StudiesHospital CostsHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHumansIncidenceInpatientsLower ExtremityMaleMiddle AgedPeripheral Arterial DiseasePostoperative ComplicationsPostoperative PeriodPrognosisRegistriesRetrospective StudiesUnited StatesYoung AdultConceptsPeripheral endovascular interventionsHospitalization costsEndovascular interventionInhospital mortalityAmputation rateHospital volumePrimary outcomeCharlson co-morbidity index scoreUtilization Project Nationwide Inpatient Sample databaseLower Extremity Endovascular InterventionsTwo-level hierarchical multivariateNationwide Inpatient Sample databaseHospital volume quartilesCo-morbidity statusHospital procedural volumeLower amputation ratesAppropriate International ClassificationHigh-volume centersAnnual institutional volumeWeekend admissionSecondary outcomesPostprocedural complicationsStudy cohortNinth RevisionVolume centersComparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting
Panaich SS, Arora S, Patel N, Patel NJ, Lahewala S, Solanki S, Manvar S, Savani C, Jhamnani S, Singh V, Patel SV, Thakkar B, Patel A, Deshmukh A, Chothani A, Bhatt P, Savani GT, Patel J, Mavani K, Bhimani R, Tripathi B, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest JK, Badheka AO. Comparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting. The American Journal Of Cardiology 2015, 116: 634-641. PMID: 26096999, DOI: 10.1016/j.amjcard.2015.05.031.Peer-Reviewed Original ResearchConceptsLower amputation ratesInhospital mortalityPostprocedural complicationsHospitalization costsEndovascular stentingAmputation rateUtilization Project Nationwide Inpatient Sample databaseTwo-level hierarchical multivariateNationwide Inpatient Sample databaseComposite end pointPeripheral arterial diseaseHigher hospitalization costsAppropriate International ClassificationPeripheral endovascular interventionsInhospital outcomesSecondary outcomesPeripheral angioplastyPrimary outcomeArterial diseaseClinical outcomesStudy cohortNinth RevisionPatency ratesEndovascular interventionAngioplastyTrends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease
Badheka AO, Singh V, Patel NJ, Arora S, Patel N, Thakkar B, Jhamnani S, Pant S, Chothani A, Macon C, Panaich SS, Patel J, Manvar S, Savani C, Bhatt P, Panchal V, Patel N, Patel A, Patel D, Lahewala S, Deshmukh A, Mohamad T, Mangi AA, Cleman M, Forrest JK. Trends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease. The American Journal Of Cardiology 2015, 116: 132-141. PMID: 25983278, DOI: 10.1016/j.amjcard.2015.03.053.Peer-Reviewed Original ResearchConceptsAortic valve diseaseCost of hospitalizationInhospital mortalityHeart failureValve diseaseHigh burdenEconomic burdenFrequent coexisting conditionsOverall inhospital mortalitySubgroup of patientsValvular heart diseaseInnovative therapeutic optionsNationwide Inpatient SamplePrincipal discharge diagnosisNumber of hospitalizationsTrend of hospitalizationsPublic health systemRenal failureAortic stenosisDischarge diagnosisNinth RevisionTherapeutic optionsPatient populationInpatient SampleCoexisting conditionsComparison of Inhospital Mortality, Length of Hospitalization, Costs, and Vascular Complications of Percutaneous Coronary Interventions Guided by Ultrasound Versus Angiography
Singh V, Badheka AO, Arora S, Panaich SS, Patel NJ, Patel N, Pant S, Thakkar B, Chothani A, Deshmukh A, Manvar S, Lahewala S, Patel J, Patel S, Jhamnani S, Bhinder J, Patel P, Savani GT, Patel A, Mohamad T, Gidwani UK, Brown M, Forrest JK, Cleman M, Schreiber T, Grines C. Comparison of Inhospital Mortality, Length of Hospitalization, Costs, and Vascular Complications of Percutaneous Coronary Interventions Guided by Ultrasound Versus Angiography. The American Journal Of Cardiology 2015, 115: 1357-1366. PMID: 25824542, DOI: 10.1016/j.amjcard.2015.02.037.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCoronary AngiographyCoronary Artery DiseaseCoronary VesselsCosts and Cost AnalysisFemaleFollow-Up StudiesHealth Care CostsHospital MortalityHumansLength of StayMaleMiddle AgedPercutaneous Coronary InterventionPostoperative ComplicationsRetrospective StudiesSurgery, Computer-AssistedUltrasonography, InterventionalUnited StatesYoung AdultConceptsPercutaneous coronary interventionCo-morbidity burdenInhospital mortalityAcute myocardial infarctionHospital stayCoronary interventionVascular complicationsMyocardial infarctionConventional angiography-guided PCIOutcomes of PCIAngiography-guided percutaneous coronary interventionDrug-eluting stent eraHierarchical mixed-effects logistic regression modelsHigher co-morbidity burdenUse of IVUSHigher hospital volumeLength of hospitalizationIntravascular ultrasound guidanceSubgroup of patientsNationwide Inpatient SampleCost of hospitalizationSignificant predictorsMixed effects logistic regression modelsMixed-effects linear regression modelsCost of careMulti‐Drug–Resistant Hypertension Caused by Severe Aortic Coarctation Presenting in Late Adulthood
Meller SM, Fahey JT, Setaro JF, Forrest JK. Multi‐Drug–Resistant Hypertension Caused by Severe Aortic Coarctation Presenting in Late Adulthood. Journal Of Clinical Hypertension 2015, 17: 313-316. PMID: 25644790, PMCID: PMC8032136, DOI: 10.1111/jch.12495.Peer-Reviewed Original ResearchConceptsAortic coarctationRefractory hypertensionStent implantationSuccessful blood pressure controlElevated renin levelsSevere aortic coarctationDrug-resistant hypertensionBlood pressure controlPercutaneous stent implantationTreatment of coarctationEndovascular stent implantationLong-term improvementLate adulthoodVerapamil monotherapyRenin levelsResistant hypertensionFemale patientsRare etiologyCongenital narrowingDisease entityDifferential diagnosisHypertensionCoarctationPressure controlAdulthood