Featured Publications
Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Ramlawi B, Gleason TG, Meduri CU, Yakubov SJ, Jilaihawi H, Liu F, Reardon MJ. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 1749-1759. PMID: 32473890, DOI: 10.1016/j.jcin.2020.03.022.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBicuspid Aortic Valve DiseaseFemaleHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsAortic valve stenosisBicuspid aortic valve stenosisTranscatheter aortic valve replacementEvolut PRO valveAortic valve replacementValve stenosisTVT RegistryCause mortalityValve replacementEvolut RBicuspid valveBicuspid Versus Tricuspid Aortic ValvesSTS/ACC TVT RegistryThoracic Surgeons/American CollegeTricuspid aortic valve stenosisCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisRate of strokeSelf-expanding valvesLow complication rateTricuspid aortic valveAcceptable safety outcomesCardiac comorbiditiesEchocardiographic outcomesAortic stenosis
2024
3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study
Zahr F, Ramlawi B, Reardon M, Deeb G, Yakubov S, Song H, Kleiman N, Chetcuti S, Gada H, Mumtaz M, Leung S, Merhi W, Rovin J, DeFrain M, Muppala M, Kauten J, Rajagopal V, Huang J, Ito S, Forrest J. 3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study. JACC Cardiovascular Interventions 2024, 17: 1667-1675. PMID: 39048253, DOI: 10.1016/j.jcin.2024.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBioprosthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProsthesis DesignRecovery of FunctionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementRates of all-cause mortalityAll-cause mortalityAortic stenosisThoracic Surgeons Predicted Risk of Mortality scoreThoracic Surgeons Predicted RiskSevere paravalvular aortic regurgitationBicuspid aortic valve anatomyRisk of Mortality scoreEchocardiographic core laboratoryLow-surgical risk patientsAortic valve anatomyKaplan-Meier ratesLow surgical riskClinical events committeeAortic valve replacementSevere aortic stenosisParavalvular aortic regurgitationPermanent pacemaker implantationBicuspid aortic stenosisFavorable hemodynamic performanceEvaluated 3 yearsAttempted implantEchocardiographic outcomesAortic regurgitationReinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb K, Lisko J, O'Hair D, Merhi W, Forrest J, Mahoney P, Van Mieghem N, Windecker S, Yakubov S, Williams M, Chetcuti S, Deeb G, Kleiman N, Althouse A, Reardon M. Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis. JACC Cardiovascular Interventions 2024, 17: 1007-1016. PMID: 38573257, DOI: 10.1016/j.jcin.2024.01.292.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansIncidenceMalePostoperative ComplicationsProsthesis DesignRandomized Controlled Trials as TopicRetreatmentRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementIncidence of reinterventionAortic valve replacementCumulative incidence of reinterventionValve replacementValve reinterventionCumulative incidenceCoreValve transcatheter aortic valve replacementLow incidence of reinterventionSurgical aortic valve replacement patientsSingle-arm studyFirst-generation CoreValveEvolut R/ProParavalvular regurgitationReinterventionRandomized trialsLow incidenceCoreValvePooled dataTranscatheterIncidenceTreatmentYearsEndocarditis
2022
Emergent Repair of Acute Type A Aortic Dissection From Transcatheter Aortic Valve Replacement
Hameed I, Boix-Garibo R, Ahmed A, Forrest JK, Vallabhajosyula P. Emergent Repair of Acute Type A Aortic Dissection From Transcatheter Aortic Valve Replacement. Canadian Journal Of Cardiology 2022, 38: 404-406. PMID: 35031349, DOI: 10.1016/j.cjca.2022.01.003.Peer-Reviewed Original Research
2021
Alternate accesses for transcatheter aortic valve replacement: A network meta‐analysis
Hameed I, Oakley CT, Hameed NUF, Ahmed A, Naeem N, Singh S, Rizwana K, Brackett A, Forrest JK, Kaple R, Mangi A, Salemi A, Geirsson A, Gaudino M, Vallabhajosyula P. Alternate accesses for transcatheter aortic valve replacement: A network meta‐analysis. Journal Of Cardiac Surgery 2021, 36: 4308-4319. PMID: 34494307, DOI: 10.1111/jocs.15961.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementTF accessValve replacementHigher long-term mortalityLong-term strokeSuperior postoperative outcomesLong-term mortalityRandom-effects networkComprehensive literature searchDifferent treatment groupsPostoperative outcomesTransfemoral accessRandomized trialsTA accessTranscarotidTreatment groupsTransapicalLiterature searchTC accessCombination of TFSignificant differencesStrokeProbability rankMortality
2020
Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve
Attizzani GF, Dallan LAP, Markowitz A, Yakubov SJ, Deeb GM, Reardon MJ, Forrest JK, Mangi AA, Huang J, Popma JJ. Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve. JACC Cardiovascular Interventions 2020, 13: 1816-1824. PMID: 32763073, DOI: 10.1016/j.jcin.2020.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsEvolut RPrimary outcomeValve Academic Research Consortium-2Academic Research Consortium-2Evolut Low Risk trialPrior percutaneous coronary interventionTranscatheter aortic valve replacementEvolut PRO valveLow-risk trialsThoracic Surgeons scoreAortic valve replacementPercutaneous coronary interventionSelf-expandable valvesTranscatheter aortic valveDisabling strokeEvolut valvesSURTAVI trialCause mortalityTrial patientsCoronary interventionSecondary outcomesSurgeons scoreValve replacementClinical outcomesAortic valveThree Generations of Self-Expanding Transcatheter Aortic Valves A Report From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Tang GHL, Yakubov SJ, Nazif TM, Williams MR, Zhang A, Popma JJ, Reardon MJ. Three Generations of Self-Expanding Transcatheter Aortic Valves A Report From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 170-179. PMID: 31973793, DOI: 10.1016/j.jcin.2019.08.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve InsufficiencyAortic Valve StenosisBioprosthesisFemaleHeart Valve ProsthesisHemodynamicsHumansMaleProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsEvolut PRO valveTranscatheter aortic valveTVT RegistryAortic regurgitationEvolut RAortic valveSelf-expanding transcatheter aortic valveSTS/ACC TVT RegistryThoracic Surgeons/American CollegeMean aortic valve gradientTranscatheter aortic valve replacement (TAVR) technologyCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisAortic valve gradientSignificant aortic regurgitationMild aortic regurgitationSupra-annular valveTranscatheter valve technologyValve gradientHemodynamic statusAortic stenosisAortic annulusEarly outcomesEchocardiographic dataPatient risk
2019
The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions
Nazif TM, Chen S, Codner P, Grossman PM, Menees DS, Sanchez CE, Yakubov SJ, White J, Kapadia S, Whisenant BK, Forrest JK, Krishnaswamy A, Arshi A, Orford JL, Leon MB, Dizon JM, Kodali SK, Chetcuti SJ. The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions. Catheterization And Cardiovascular Interventions 2019, 95: 1051-1056. PMID: 31478304, DOI: 10.1002/ccd.28476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Pacing, ArtificialCardiac Surgical ProceduresEquipment DesignFemaleHeart RateHumansMalePacemaker, ArtificialPatient SafetyPerioperative CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Function, RightConceptsTemporary cardiac pacingTemporary pacing leadStructural heart proceduresPacing leadsHeart proceduresCardiac pacingMulticenter retrospective studyMobilization of patientsRisk of perforationActive fixation mechanismStructural heart interventionsPericardial effusionRetrospective studyLead dislodgmentMean durationPace captureRight ventricleLead stabilitySignificant perforationPatientsHeart interventionsLead performancePacingCapture thresholdPerforation
2018
Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement
Mori M, Bin Mahmood SU, Geirsson A, Yun JJ, Cleman MW, Forrest JK, Mangi AA. Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2018, 93: e337-e342. PMID: 30269424, DOI: 10.1002/ccd.27855.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overAortic ValveFemaleHeart Valve Prosthesis ImplantationHospitals, High-VolumeHumansMalePatient Reported Outcome MeasuresPractice Patterns, Physicians'Retrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementAortic valve replacementSTS-PROMSAVR volumeSAVR cohortValve replacementCase volumeTranscatheter aortic valve replacementRisk profileTranscatheter aortic valve replacement (TAVR) programHigh-volume academic medical centerRisk categoriesStudy periodContemporary temporal trendsMedian STS PROMProportion of patientsRisk of mortalityLow-risk categoryAcademic medical centerPROM patientsTAVR cohortTAVR volumeTAVR patientsConsecutive patientsIntermediate riskVentricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014
Goldsweig AM, Wang Y, Forrest JK, Cleman MW, Minges KE, Mangi AA, Aronow HD, Krumholz HM, Curtis JP. Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014. Catheterization And Cardiovascular Interventions 2018, 92: 1104-1115. PMID: 29513365, DOI: 10.1002/ccd.27576.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionVentricular septal ruptureTimely primary PCIMortality ratePrimary PCIPercutaneous repairSeptal ruptureMyocardial infarctionRetrospective cohort studyUnadjusted mortality ratesUnrepaired patientsVSR repairFatal complicationCohort studyAnnual incidenceMedicare feeService beneficiariesPatientsIncidenceStudy periodMortalityHospitalizationInfarctionRepairPCI
2017
Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials
Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials. European Heart Journal 2017, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.Peer-Reviewed Original ResearchConceptsCardiovascular proceduresClinical trialsNeurological endpointsAcademic Research ConsortiumBenefit-risk assessmentAdjunctive pharmacologyNeurological complicationsNeurological outcomePreventive therapyClinical effectsNeurovascular injuryNeurological injuryNeurological riskEndpoint definitionsCardiovascular interventionsAscertainment methodsTherapyInjuryResearch ConsortiumRiskTrialsEndpointInherent risksSuch proceduresComplications
2016
Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial)
Lansky AJ, Brown D, Pena C, Pietras CG, Parise H, Ng VG, Meller S, Abrams KJ, Cleman M, Margolis P, Petrossian G, Brickman AM, Voros S, Moses J, Forrest JK. Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial). The American Journal Of Cardiology 2016, 118: 1519-1526. PMID: 27645761, DOI: 10.1016/j.amjcard.2016.08.013.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic ValveAortic Valve StenosisBrainBrain IschemiaDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansIncidenceIntracranial EmbolismMalePostoperative ComplicationsPrognosisProspective StudiesRisk AssessmentRisk FactorsSurvival RateTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationAortic valve implantationNeurologic injuryValve implantationNeurologic impairmentMagnetic resonance imaging lesionsCognitive AssessmentMontreal Cognitive Assessment scoreCerebral ischemic lesionsNew neurologic impairmentSubclinical cerebral infarctsDiffusion-weighted magnetic resonance imagingTotal lesion volumeCognitive Assessment scoreMontreal Cognitive AssessmentMagnetic resonance imagingCerebral embolizationCerebral infarctsNeurologic complicationsCerebral infarctionImaging lesionsMost patientsOvert strokeConsecutive patientsIschemic lesions
2015
Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation
Bhatt P, Patel NJ, Patel A, Sonani R, Patel A, Panaich SS, Thakkar B, Savani C, Jhamnani S, Patel N, Patel N, Pant S, Patel S, Arora S, Dave A, Singh V, Chothani A, Patel J, Ansari M, Deshmukh A, Bhimani R, Grines C, Cleman M, Mangi A, Forrest JK, Badheka AO. Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation. The American Journal Of Cardiology 2015, 116: 1418-1424. PMID: 26471501, DOI: 10.1016/j.amjcard.2015.07.066.Peer-Reviewed Original ResearchConceptsLength of stayAnnual hospital volumeShorter LOSNationwide Inpatient Sample databaseHospital volumeProcedure-related complicationsEndovascular stentingNinth RevisionInternational ClassificationUtilization Project Nationwide Inpatient Sample databaseClinical Modification procedure codesAdult aortic coarctationUnique hospital identifiersNationwide Inpatient SampleTreatment of coarctationMultivariate regression analysisComposite outcomeHighest tertileInhospital deathAortic coarctationRetrospective studyInpatient SampleStent placementLower incidenceIdentified subjectsMechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample)
Singh V, Patel SV, Savani C, Patel NJ, Patel N, Arora S, Panaich SS, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample). The American Journal Of Cardiology 2015, 116: 1574-1580. PMID: 26434512, DOI: 10.1016/j.amjcard.2015.08.020.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationMechanical circulatory support devicesAortic valve implantationCirculatory support devicesMCS devicesValve implantationHigh-risk surgical patientsPropensity score-matched analysisClinical Modification procedure codesSupport devicesVentricular fibrillation arrestNationwide Inpatient SampleCost of hospitalizationShort-term useSignificant increaseUnacceptably high ratesInhospital mortalityInhospital outcomesCardiogenic shockIndependent predictorsSurgical patientsNinth RevisionTAVI procedureTransapical accessInpatient SampleTrends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease
Badheka AO, Singh V, Patel NJ, Arora S, Patel N, Thakkar B, Jhamnani S, Pant S, Chothani A, Macon C, Panaich SS, Patel J, Manvar S, Savani C, Bhatt P, Panchal V, Patel N, Patel A, Patel D, Lahewala S, Deshmukh A, Mohamad T, Mangi AA, Cleman M, Forrest JK. Trends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease. The American Journal Of Cardiology 2015, 116: 132-141. PMID: 25983278, DOI: 10.1016/j.amjcard.2015.03.053.Peer-Reviewed Original ResearchConceptsAortic valve diseaseCost of hospitalizationInhospital mortalityHeart failureValve diseaseHigh burdenEconomic burdenFrequent coexisting conditionsOverall inhospital mortalitySubgroup of patientsValvular heart diseaseInnovative therapeutic optionsNationwide Inpatient SamplePrincipal discharge diagnosisNumber of hospitalizationsTrend of hospitalizationsPublic health systemRenal failureAortic stenosisDischarge diagnosisNinth RevisionTherapeutic optionsPatient populationInpatient SampleCoexisting conditions