2022
A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
Schuster JE, Halasa NB, Nakamura M, Levy ER, Fitzgerald JC, Young CC, Newhams MM, Bourgeois F, Staat MA, Hobbs CV, Dapul H, Feldstein LR, Jackson AM, Mack EH, Walker TC, Maddux AB, Spinella PC, Loftis LL, Kong M, Rowan CM, Bembea MM, McLaughlin GE, Hall MW, Babbitt CJ, Maamari M, Zinter MS, Cvijanovich NZ, Michelson KN, Gertz SJ, Carroll CL, Thomas NJ, Giuliano JS, Singh AR, Hymes SR, Schwarz AJ, McGuire JK, Nofziger RA, Flori HR, Clouser KN, Wellnitz K, Cullimore ML, Hume JR, Patel M, Randolph AG, Investigators O. A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020. Journal Of The Pediatric Infectious Diseases Society 2022, 11: piab123-. PMID: 35022779, PMCID: PMC8807297, DOI: 10.1093/jpids/piab123.Peer-Reviewed Original ResearchMeSH KeywordsChildCOVID-19 Drug TreatmentCritical IllnessHospitalizationHospitals, PediatricHumansIntensive Care UnitsUnited StatesConceptsCOVID-19-directed therapiesAcute coronavirus disease 2019Life-threatening COVID-19COVID-19Acute COVID-19Underlying medical conditionsIntensive care unitHigh-acuity careCoronavirus disease 2019Half of childrenYears of ageCharacteristics of childrenRemdesivir useSystemic steroidsRespiratory supportClinical courseCare unitPediatric hospitalSpecific therapyPediatric dataIll childrenLaboratory valuesDisease 2019Medical conditionsUS hospitalsPediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.Peer-Reviewed Original ResearchMeSH KeywordsChildCritical CareCritical IllnessEvidence-Based MedicineHumansMultiple Organ FailureOrgan Dysfunction ScoresConceptsMultiple organ dysfunctionOrgan dysfunctionIll childrenElectronic data extraction formSingle organ dysfunctionPrognosis Studies toolRisk of biasImmune system dysfunctionMedical Subject Headings termsEvidence-based criteriaData extraction formSubject Headings termsAcute liverSystem dysfunctionClinical assessmentElectronic searchDysfunctionExtraction formSystematic reviewAvailable evidenceExpert panelMeaningful outcomesStudy identificationChildrenStudy toolEndothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s97-s102. PMID: 34970676, PMCID: PMC9754809, DOI: 10.1542/peds.2021-052888o.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildCritical IllnessEndotheliumHumansMultiple Organ FailureOrgan Dysfunction ScoresConceptsMultiple organ dysfunction syndromeOrgan dysfunction syndromeEndothelial dysfunctionIll childrenDysfunction syndromeEndothelial functionPediatric multiple organ dysfunction syndromeVascular segmentsOrgan systemsStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferencePatient-centered outcomesNon-English language studiesCombination of biomarkersData extraction formStudies of adultsCritical illnessCase seriesPremature infantsFunctional statusEligible studiesBias assessmentLeukocyte recruitment
2017
Endothelial Cell Function and Dysfunction in Critically Ill Children
Pierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children. Pediatrics 2017, 140: e20170355. PMID: 28759412, PMCID: PMC9923607, DOI: 10.1542/peds.2017-0355.Peer-Reviewed Original ResearchMeSH KeywordsCapillary PermeabilityChildCritical IllnessEndothelial CellsHemostasisHomeostasisHumansInflammationRegional Blood FlowConceptsEndothelial cellsCritical illnessIll childrenCritically Ill ChildrenImmune cell recruitmentBiology of ECsEndothelial cell functionBroad anatomic distributionEntire vascular systemPathologic responseAnatomic distributionClinical correlationMaintenance of homeostasisBlood flowCell recruitmentBlood fluiditySystemic homeostasisCell functionSegmental differencesEC functionVascular systemIllnessChildrenHomeostasisSpecific role
2016
A regional cohort study of the treatment of critically ill children with bronchiolitis
Carroll CL, Faustino EV, Pinto MG, Sala KA, Canarie MF, Li S, Giuliano JS, Consortium T. A regional cohort study of the treatment of critically ill children with bronchiolitis. Journal Of Asthma 2016, 53: 1006-1011. PMID: 27177013, DOI: 10.1080/02770903.2016.1180697.Peer-Reviewed Original ResearchConceptsRSV bronchiolitisChildren's HospitalMechanical ventilationIll childrenChest physiotherapyICU lengthCohort studyMedical CenterConnecticut Children's Medical CenterHigh-flow nasal cannulaYale-New Haven Children's HospitalRegional cohort studyInvasive mechanical ventilationLonger ICU lengthRetrospective cohort studyRisk of intubationMortality risk scoreIntrapulmonary percussive ventilationChildren's Medical CenterUse of therapiesIntensive care courseClinical characteristicsNasal cannulaHypertonic salineMore frequent use
2013
Corticosteroid Therapy in Critically Ill Pediatric Asthmatic Patients*
Giuliano JS, Faustino EV, Li S, Pinto MG, Canarie MF, Carroll CL. Corticosteroid Therapy in Critically Ill Pediatric Asthmatic Patients*. Pediatric Critical Care Medicine 2013, 14: 467-470. PMID: 23628833, DOI: 10.1097/pcc.0b013e31828a7451.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdrenal Cortex HormonesAdultAlbuterolAsthmaCanadaChildCritical IllnessCross-Sectional StudiesGuideline AdherenceHumansIntensive Care Units, PediatricLogistic ModelsMethylprednisoloneMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'United StatesConceptsBlood Institute guidelinesStarting doseNational HeartInstitute guidelinesClinical experienceMultivariate logistic regression analysisIll patient populationInitial corticosteroid doseMajority of asthmaticsNorth American PICUsPediatric asthmatic patientsSpecific dosing recommendationsEvidence-based dataLogistic regression analysisContinuous albuterolCorticosteroid dosageCorticosteroid doseCorticosteroid therapyIll asthmaticsPICU experienceAsthmatic patientsAsthmatic childrenIndependent predictorsDosing recommendationsMost intensivists