2020
Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use
Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.Peer-Reviewed Original ResearchMeSH KeywordsCannabinoidsCannabisChromatography, LiquidDronabinolHumansProspective StudiesSubstance Abuse DetectionTandem Mass SpectrometryConceptsCannabis useUrine samplesLoss of appetiteMinor cannabinoidsRapid LC-MS/MSDronabinol groupDronabinol therapyDronabinol useSevere nauseaPain managementPositive subjectsNormal controlsTherapeutic potentialProspective sampleClinical urine samplesCancer chemotherapySpecific populationsCannabisCannabinoidsMetabolite concentrationsDronabinolLC-MS/MSNegative controlDetection of cannabisCannabidiol
2019
Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse.
Smith WR, McClish DK, Roberts JD, Kandalaft O, Dahman B, Knisely J, Levenson J, Roseff S, Aisiku IP. Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse. Journal Of Opioid Management 2019, 15: 323-331. PMID: 31637684, DOI: 10.5055/jom.2019.0517.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnemia, Sickle CellFemaleHumansMaleOpioid-Related DisordersProspective StudiesRisk AssessmentSurveys and QuestionnairesConceptsOpioid misuseOpioid abuseAdult sickle cell disease patientsPrescription Opioid Misuse IndexSickle cell disease patientsAdult SCD patientsChronic opioid therapyGroup of patientsSickle cell clinicSickle cell patientsDiagnostic Interview ScheduleDSM-IV criteriaUrban teaching facilityOpioid therapySCD clinicOpioid usageAdult patientsRisk patientsSecondary outcomesHemoglobin SSPrimary outcomeSCD patientsMean ageDisease patientsProspective survey
2018
A Phase II Trial of Bortezomib and Vorinostat in Mantle Cell Lymphoma and Diffuse Large B-cell Lymphoma
Yazbeck V, Shafer D, Perkins EB, Coppola D, Sokol L, Richards KL, Shea T, Ruan J, Parekh S, Strair R, Flowers C, Morgan D, Kmieciak M, Bose P, Kimball A, Badros AZ, Baz R, Lin HY, Zhao X, Reich RR, Tombes MB, Shrader E, Sankala H, Roberts JD, Sullivan D, Grant S, Holkova B. A Phase II Trial of Bortezomib and Vorinostat in Mantle Cell Lymphoma and Diffuse Large B-cell Lymphoma. Clinical Lymphoma Myeloma & Leukemia 2018, 18: 569-575.e1. PMID: 30122201, DOI: 10.1016/j.clml.2018.05.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBortezomibDrug Resistance, NeoplasmFemaleFollow-Up StudiesHumansLymphoma, Large B-Cell, DiffuseLymphoma, Mantle-CellMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisProspective StudiesSalvage TherapySurvival RateVorinostatConceptsLarge B-cell lymphomaPhase II trialStable diseaseProgressive diseaseB-cell lymphomaPartial responseII trialCohort BCohort ADay 1Median progression-free survivalNonrandomized phase II trialDiffuse large B-cell lymphomaProgression-free survivalHistone deacetylase inhibitor vorinostatOverall response rateCombination of bortezomibMantle cell lymphomaNF-κB activationProteasome inhibitor bortezomibCell lymphoma cellsPresent multicenterRefractory MCLClinical responseCohort C
2017
Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project
Smith WR, McClish DK, Levenson J, Aisiku I, Dahman B, Bovbjerg VE, Roseff S, Roberts J. Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project. Pain Medicine 2017, 19: 1972-1981. PMID: 29036363, PMCID: PMC6176749, DOI: 10.1093/pm/pnx214.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysPain assessmentPain measuresOne weekGold standardSickle Cell Epidemiology StudyMonths strategyDaily pain assessmentProspective cohort studyOne dayPiSCES projectCohort studySCD patientsMeasurement of R2Month assessmentCell diseasePainEpidemiology studiesDiary assessmentsDaily assessmentIntermittent assessmentCrisis daysWeeksMonths
2008
Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease
Aisiku IP, Smith WR, McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD. Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease. Annals Of Emergency Medicine 2008, 53: 587-593. PMID: 18926599, DOI: 10.1016/j.annemergmed.2008.07.050.Peer-Reviewed Original ResearchConceptsSickle cell disease patientsHigh ED utilizersSickle cell diseaseDisease patientsEmergency departmentCell diseaseQuality of lifeFrequency of painSickle cell painDescriptors of painBaseline dataLower hematocrit levelsHealth dataPain daysMore transfusionsPain characteristicsPain crisisED utilizationLaboratory variablesHigh utilizersMore painPainHematocrit levelsPatientsSummary scales
2007
Patient satisfaction in specialized versus nonspecialized adult sickle cell care centers: the PiSCES study.
Aisiku IP, Penberthy LT, Smith WR, Bovbjerg VE, McClish DK, Levenson JL, Roberts JD, Roseff SD. Patient satisfaction in specialized versus nonspecialized adult sickle cell care centers: the PiSCES study. Journal Of The National Medical Association 2007, 99: 886-90. PMID: 17722665, PMCID: PMC2574305.Peer-Reviewed Original ResearchConceptsNonspecialized centersPatient satisfactionSpecialized centersSCD careSCD patientsCare centerInterpersonal mannerSatisfaction scoresHighest mean satisfaction scoreSickle cell disease patientsProspective cohort studyGeneral satisfactionPatient satisfaction surveyMean satisfaction scoreQuality of careHigher satisfaction scoresSatisfaction surveySCD specialistsCohort studySignificant group differencesPotential confoundersDisease patientsAmbulatory carePatientsPractice style
2006
Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project
McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD, Aisiku IP, Smith WR. Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project. Journal Of Women's Health 2006, 15: 146-154. PMID: 16536678, DOI: 10.1089/jwh.2006.15.146.Peer-Reviewed Original ResearchConceptsHealthcare utilizationAnalysis of covarianceAdult sickle cell patientsSickle cell disease (SCD) experienceSS genotypeEpisodes of painProspective cohort studyIntensity of painSickle cell crisisSickle cell patientsHigher pain ratingsStudy of PainPiSCES projectOpioid usagePain scoresAcute painCohort studyChronic painPain ratingsLower painCell crisisCell patientsPainPain experienceDisease experience
2005
Understanding pain and improving management of sickle cell disease: the PiSCES study.
Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Gil K, Roseff SD, Aisiku IP. Understanding pain and improving management of sickle cell disease: the PiSCES study. Journal Of The National Medical Association 2005, 97: 183-93. PMID: 15712781, PMCID: PMC2568749.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain episodesPain responseHealthcare utilizationCell diseaseSickle Cell Epidemiology StudyDaily pain diaryCare-seeking behaviorSCD painAnalgesic useOverall painAdult patientsFrequent hospitalizationsPain diaryOrgan failureSCD careChronic painTreatment advancesProlonged survivalRelated disabilityTimely carePainBiobehavioral interventionsAdult cohortEpidemiology studies