2024
ChatGPT: A Reliable Laboratory Medicine Consult?
El-Khoury J. ChatGPT: A Reliable Laboratory Medicine Consult? Clinical Chemistry 2024, hvae100. PMID: 39045739, DOI: 10.1093/clinchem/hvae100.Peer-Reviewed Original ResearchAccounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin
Militello L, El-Khoury J, Durant T. Accounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin. Clinica Chimica Acta 2024, 562: 119851. PMID: 38977172, DOI: 10.1016/j.cca.2024.119851.Peer-Reviewed Original ResearchPuzzling undetectable haptoglobin in a transfused pregnant patient
Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionUndetectable haptoglobin levelUndetectable haptoglobinPregnant patientsHaptoglobin levelsB-cell acute lymphocytic leukemiaPregnancy-related physiological changesTrimester-specific reference intervalsReference intervalsCenters for Disease Control (CDC) criteriaDiagnosis of hemolysisNon-pregnant counterpartsTrimester of pregnancyAcute lymphocytic leukemiaHemolytic transfusion reactionsMultidisciplinary approach to patient careFollow-up visitRed cell unitsLactate dehydrogenasePhysiological changesRBC transfusionThird trimesterLymphocytic leukemiaLaboratory findingsImmunological markersTime to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals?
El-Khoury J, Badrick T, Theodorsson E. Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals? Clinical Chemistry 2024, 70: 700-702. PMID: 38498011, DOI: 10.1093/clinchem/hvae026.Peer-Reviewed Original ResearchGlycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real?
Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.Peer-Reviewed Original ResearchBiomarkers vs Machines: The Race to Predict Acute Kidney Injury
Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.Peer-Reviewed Original ResearchAcute kidney injuryEarly diagnosisInsulin-like growth factor-binding protein 7Prediction of acute kidney injuryGrowth factor-binding protein 7Detect acute kidney injuryNeutrophil gelatinase-associated lipocalinAcute kidney injury detectionClinical practiceIrreversible kidney damageClinical outcome studiesImminent AKISerum creatinineKidney injuryInjury markersPediatric populationCystatin CTissue inhibitorHospitalized patientsClinical useKidney damageRegulatory approvalProtein 7BiomarkersOutcome studiesRenalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19
Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.Peer-Reviewed Original Research
2023
Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 37931733, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchUnexpected Negative Zolpidem Urine Drug Test in a Compliant Patient
Shang E, Choucair I, El-Khoury J. Unexpected Negative Zolpidem Urine Drug Test in a Compliant Patient. Clinical Chemistry 2023, 69: 1435-1436. PMID: 38037440, DOI: 10.1093/clinchem/hvad149.Peer-Reviewed Original ResearchRapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T.
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchConceptsRapid Serum TubesPlasma separation tubesHigh-sensitivity troponin THs-cTnT valuesHs-cTnTSource of hemolysisEmergency departmentTroponin TSerum tubesFalse positive resultsMedian reductionEffect of hemolysisED patientsSample collectionEffects of tube typeHemolysisPatientsPositive resultsSeparator tubesInternational Perspectives on GFR Estimation and Race-Based Adjustments
El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.Peer-Reviewed Original ResearchLaboratory-developed tests: The forgotten majority
El-Khoury J. Laboratory-developed tests: The forgotten majority. American Journal Of Clinical Pathology 2023, 160: 541-541. PMID: 37449363, DOI: 10.1093/ajcp/aqad080.Peer-Reviewed Original ResearchCannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization
Tolan N, Krasowski M, Mathias P, Wiencek J, Babic N, Chai P, Chambliss A, Choucair I, Demetriou C, Erickson T, Feldhammer M, French D, Hayes B, Kang P, El-Khoury J, Knezevic C, Monte A, Nerenz R, Okorodudu A, Roper S, Saitman A, Thiriveedhi V, Uljon S, Vest A, Woodworth A, Yu M, Melanson S. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Clinical Toxicology 2023, 61: 248-259. PMID: 37129223, PMCID: PMC10793079, DOI: 10.1080/15563650.2023.2177552.Peer-Reviewed Original ResearchHemolysis or wine? A case of red-wine-colored plasma
Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.Peer-Reviewed Original ResearchSeasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription
El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023, 69: 537-538. PMID: 36857303, DOI: 10.1093/clinchem/hvad017.Peer-Reviewed Original ResearchVitamin D and Bone Fractures Revisited
Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209-209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.Peer-Reviewed Original Research
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsCompliance or Abuse? Detectable hydromorphone in patients taking oxycodone
Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.Peer-Reviewed Original ResearchBilateral upper extremity paresthesiasMetabolites of oxycodoneUpper extremity paresthesiasUrine drug monitoringUrine samplesMiddle-aged womenQuality improvement projectPositive urine samplesAspen collarOpioid therapyOxycodone preparationsMechanical fallOpioid medicationsExtremity paresthesiasCervical diskectomyChronic painSurgical interventionUrine testsOrthopaedic servicesSpinal fusionOxycodonePatientsHydromorphoneDrug monitoringHydrocodoneLow haptoglobin in pregnancy: physiological or intravascular hemolysis?
Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionTrimester-specific reference intervalsNormal lactate dehydrogenaseSecond trimesterThird trimesterFirst trimesterReference intervalsIntravascular hemolysisLactate dehydrogenaseLow haptoglobinB-cell acute lymphoblastic leukemiaRemnant serum samplesDisease Control criteriaElevated total bilirubinRed cell transfusionNon-pregnant populationHemolytic transfusion reactionsHigh estrogen statesAcute lymphoblastic leukemiaLow haptoglobin levelsCombination of pregnancyQuality improvement projectOverall reference intervalRed cell unitsInduction chemotherapyRising to the Challenge: Shortages in Laboratory Medicine
Knezevic CE, Das B, El-Khoury JM, Jannetto PJ, Lacbawan F, Winter WE. Rising to the Challenge: Shortages in Laboratory Medicine. Clinical Chemistry 2022, 68: 1486-1492. PMID: 36301321, DOI: 10.1093/clinchem/hvac179.Peer-Reviewed Original Research