2016
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation
Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 2016, 45: 1219-1231. PMID: 27913094, PMCID: PMC5538583, DOI: 10.1016/j.immuni.2016.11.004.Peer-Reviewed Original ResearchConceptsCommon lymphoid progenitorsHematopoietic stem cellsMesenchymal progenitorsProgenitor differentiationHSC nicheCell lineage decisionsBone marrow nicheHSC maintenanceLineage decisionsDifferentiation signalsCytokines SCFEndothelial cellsSeparate nichesLymphoid progenitorsMultilineage differentiationMarrow nicheNicheChemokine receptor CXCR4Conditional deletionIL-7 receptorStem cellsProgenitorsDifferentiationIL-7Deletion
2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow
Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. Journal Of Experimental Medicine 2014, 211: 2567-2581. PMID: 25403444, PMCID: PMC4267240, DOI: 10.1084/jem.20140457.Peer-Reviewed Original ResearchConceptsGαi protein-coupled receptorsBone marrowCell egressImmature-B cell egressB cell egressTwo-photon intravital microscopyB cell retentionImmature B cellsBM parenchymaProtein-coupled receptorsNK cellsB lineage cellsImmature BLymphoid organsVCAM-1Pertussis toxinB cellsSinusoidal endotheliumIntravital microscopyCXCR4Lineage cellsHematopoietic cellsMarrowCellsMotility