2023
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, Müschen M, Choi J, Pereira J. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. ELife 2023, 12: e83533. PMID: 36912771, PMCID: PMC10042536, DOI: 10.7554/elife.83533.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsLymphotoxin beta receptorLeukemic cellsBeta receptorsLeukemic cell growthBone marrow microenvironmentStem cellsTransplant recipientsAML cellsMyeloblastic leukemiaMouse modelBone marrowLeukemia growthLymphotoxin α1β2Marrow microenvironmentPharmacological disruptionLymphopoiesisReceptorsHematopoietic outputMolecular mechanismsErythropoiesisDNA damage response pathwayCell growthCellsPhysiological mechanismsMature B cells and mesenchymal stem cells control emergency myelopoiesis
Lim V, Feng X, Miao R, Zehentmeier S, Ewing-Crystal N, Lee M, Tumanov A, Oh J, Iwasaki A, Wang A, Choi J, Pereira J. Mature B cells and mesenchymal stem cells control emergency myelopoiesis. Life Science Alliance 2023, 6: e202301924. PMID: 36717247, PMCID: PMC9889502, DOI: 10.26508/lsa.202301924.Peer-Reviewed Original ResearchConceptsMarrow mesenchymal stem cellsSystemic inflammationMature B cellsB cellsEmergency myelopoiesisMesenchymal stem cellsIL-1 receptorBone marrow mesenchymal stem cellsStem cellsMyeloid cell productionMonocyte numbersB lineage cellsCCL2 productionViral infectionLymphotoxin α1β2InflammationReduced survivalLymphopoietic activityMyelopoiesisLymphopoiesisImportant regulatorLTβRCell productionCellsGenetic blocking
2018
Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development
Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. Journal Of Experimental Medicine 2018, 215: 2586-2599. PMID: 30158115, PMCID: PMC6170173, DOI: 10.1084/jem.20180778.Peer-Reviewed Original ResearchConceptsB cell progenitorsCell progenitorsUnrepaired double-strand DNA breaksDouble-strand DNA breaksB cell developmentMesenchymal progenitor cellsInterleukin-7IL-7R signalingFocal adhesion kinase expressionBone marrow stromal cellsCell movementMarrow stromal cellsDNA breaksPreB cellsCell developmentParacrine signalsCell behaviorAcute lymphoblastic leukemic cellsProgenitor cellsKinase expressionProgenitorsIL-7RCell exposureStromal cellsLow-adhesion state
2016
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation
Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 2016, 45: 1219-1231. PMID: 27913094, PMCID: PMC5538583, DOI: 10.1016/j.immuni.2016.11.004.Peer-Reviewed Original ResearchConceptsCommon lymphoid progenitorsHematopoietic stem cellsMesenchymal progenitorsProgenitor differentiationHSC nicheCell lineage decisionsBone marrow nicheHSC maintenanceLineage decisionsDifferentiation signalsCytokines SCFEndothelial cellsSeparate nichesLymphoid progenitorsMultilineage differentiationMarrow nicheNicheChemokine receptor CXCR4Conditional deletionIL-7 receptorStem cellsProgenitorsDifferentiationIL-7Deletion