Featured Publications
Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development
De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.Peer-Reviewed Original ResearchConceptsOpioid use disorderClinical trialsPresence of OUDSystematic reviewTreatment of OUDActive treatment groupNeurobiology of painDrug developmentSpontaneous painAntihyperalgesic effectOngoing painPharmacological managementAnalgesic effectClinical featuresCochrane DatabasePharmacological treatmentEligible studiesOpioid addictionPainTreatment groupsUse disordersAbuse liabilityNovel therapeuticsNonsignificant heterogeneityNeurobiological overlap
2022
Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies
De Aquino J, Bahji A, Gómez O, Sofuoglu M. Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies. Drug And Alcohol Dependence 2022, 241: 109702. PMID: 36434879, PMCID: PMC9772106, DOI: 10.1016/j.drugalcdep.2022.109702.Peer-Reviewed Original ResearchConceptsOpioid withdrawalObservational studySystematic reviewDelta-9-tetrahydrocannabinol administrationPlacebo-controlled clinical trialCannabis useNon-opioid therapeuticsPotential of cannabinoidsDose of opioidsOpioid withdrawal symptomsOpioid use disorderNarrow therapeutic windowExperimental human studiesDose-dependent increaseMain psychoactive constituentPatient characteristicsWithdrawal symptomsClinical trialsPharmacological factorsStudy qualityTherapeutic windowTherapeutic benefitUse disordersHuman studiesAbuse liabilityHelpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders
Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.Peer-Reviewed Original ResearchSubstance use disordersUse disordersCocaine use disorderWithdrawal symptomsAbuse liabilityMultiple substance use disordersOpioid use disorderRegulatory approval statusFurther clinical researchPotential abuse liabilityNegative subjective effectsClinical trial researchPharmacological treatmentStimulant medicationPossible treatmentReviewThis reviewTherapeutic potentialTrial researchClinical researchSubjective effectsKetamineDecrease useDisordersGabapentinoidsApproval status