2023
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparation
2015
Anti-RhD Mediates Loss of RhD Antigen Following Anti-RhD Infusion
Sullivan H, Arthur C, Patel S, Hendrickson J, Lazarus A, Stowell S. Anti-RhD Mediates Loss of RhD Antigen Following Anti-RhD Infusion. Blood 2015, 126: 3570. DOI: 10.1182/blood.v126.23.3570.3570.Peer-Reviewed Original ResearchDirect antiglobulin testAutoimmune hemolytic anemiaRed blood cellsAntigen lossAntigen levelsRhD antigenHemolytic anemiaPost-infusion samplesTarget antigenAntigen detectionRhD-positive red blood cellsK antigenIncompatible RBC transfusionIdiopathic thrombocytopenic purpuraAnti-RhD antibodiesHospital blood bankSignificant complement activationImmune globulinRBC transfusionThrombocytopenic purpuraAntiglobulin testMurine modelAntibody injectionRBC clearanceDetectable antigen