2024
Massively parallel disruption of enhancers active in human neural stem cells
Geller E, Noble M, Morales M, Gockley J, Emera D, Uebbing S, Cotney J, Noonan J. Massively parallel disruption of enhancers active in human neural stem cells. Cell Reports 2024, 43: 113693. PMID: 38271204, PMCID: PMC11078116, DOI: 10.1016/j.celrep.2024.113693.Peer-Reviewed Original ResearchHuman neural stem cellsNeural stem cellsStem cellsProliferation phenotypeAssociated with neurodevelopmental disordersNeurodevelopmental disordersEnhanced disruptionHuman Accelerated RegionsNeural progenitor proliferationEffects of genetic variationHuman cortical evolutionProgenitor proliferationSelf-renewalNeural progenitorsProgenitor populationsCerebral cortexChromatin interactionsHuman cerebral cortexNeural progenitor populationsGene regulationRegulatory elementsConserved regionGene disruptionGenetic variationRegulatory relationships
2011
Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing
Ayoub AE, Oh S, Xie Y, Leng J, Cotney J, Dominguez MH, Noonan JP, Rakic P. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14950-14955. PMID: 21873192, PMCID: PMC3169109, DOI: 10.1073/pnas.1112213108.Peer-Reviewed Original ResearchConceptsTranscriptional programsHigh-resolution transcriptome mapDifferential transcriptome analysisStem cell maintenanceUnderlying transcriptional programsTransient embryonic zonesUncharacterized genesTranscriptome mapTranscriptome analysisEmbryonic mouse forebrainCell maintenanceGenetic programEmbryonic zonesMRNA sequencingCerebral cortexMolecular pathwaysStem cellsCell populationsMouse forebrainTranscriptsCortical plateSubventricular zoneGenesSequencingCortex