2023
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell M, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. AJP Gastrointestinal And Liver Physiology 2023, 325: g379-g390. PMID: 37605828, PMCID: PMC10887843, DOI: 10.1152/ajpgi.00139.2023.Peer-Reviewed Original Research
2021
Jazf1 acts as a regulator of insulin‐producing β‐cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice
Park S, Kwon W, Park S, Jeong J, Kim D, Jang S, Kim S, Sung Y, Kim M, Choi S, Ryoo Z. Jazf1 acts as a regulator of insulin‐producing β‐cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice. The FEBS Journal 2021, 288: 4412-4427. PMID: 33555104, DOI: 10.1111/febs.15751.Peer-Reviewed Original ResearchAlcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. Journal Of Hepatology 2021, 75: 377-386. PMID: 33675874, PMCID: PMC8292196, DOI: 10.1016/j.jhep.2021.02.028.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseAlcohol-induced liver injuryLiver sinusoidal endothelial cellsAlcohol-related liver diseaseLiver injuryLSEC dysfunctionHsp90 acetylationNO productionHistone deacetylase 6Liver diseaseTherapeutic strategiesHeat shock protein 90 (Hsp90) acetylationLiver sinusoidal endothelial dysfunctionSinusoidal endothelial cell dysfunctionMouse liver sinusoidal endothelial cellsEndothelial cell dysfunctionNitric oxide synthaseEthanol-fed miceSinusoidal endothelial dysfunctionPotential therapeutic approachPotential therapeutic strategyNitric oxide productionNew therapeutic strategiesSinusoidal endothelial cellsAcetylation of Hsp90
2020
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis. Cellular And Molecular Gastroenterology And Hepatology 2020, 11: 1139-1161. PMID: 33340713, PMCID: PMC7903131, DOI: 10.1016/j.jcmgh.2020.12.007.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsCirrhotic miceSinusoidal endothelial cellsLiver cirrhosisEndothelial cellsIntrahepatic vascular resistanceCarbon tetrachloride inhalationNovel therapeutic strategiesNitric oxide productionCirrhotic mouse liverEC populationsVascular resistanceClinical complicationsLiver fibrosisTherapeutic strategiesCirrhosisOxide productionEndocytic receptorMiceAbstractTextZone 3Extracellular matrix genesVascular ECsLymphatic ECsMouse liver
2019
Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice
Sung Y, Jeong J, Kang R, Choi M, Park S, Kwon W, Lee J, Jang S, Park S, Kim S, Yi J, Choi S, Lee M, Liu K, Dong Z, Ryoo Z, Kim M. Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice. Cell Biochemistry And Function 2019, 37: 139-147. PMID: 30883865, DOI: 10.1002/cbf.3376.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCell growthΒ-cell destructionImportant regulatorLet-7 biogenesisLet-7 regulationPancreatic β-cell functionRole of Lin28Family of miRNAsRecent genome-wide association studiesΒ-cell functionPancreatic β-cell deathCell cycle progressionCell cycle regulatorsLin28/letΒ-cell deathOverexpression of Lin28aMiRNA biogenesisSkeletal myogenesisPrecise modulationEmbryonic developmentLin28a/Pancreatic β-cellsCycle regulatorsCycle progression
2018
Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity
Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi K, Choo Y, Yoon D, Kim M, Ryoo Z. Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity. Endocrine Journal 2018, 65: ej17-0363. PMID: 29434073, DOI: 10.1507/endocrj.ej17-0363.Peer-Reviewed Original ResearchConceptsHigh-fat dietDiet-induced obesityCD3/CD28 stimulationEpididymal white adipose tissueObesity-induced inflammationPlacental growth factorVascular endothelial growth factorT cellsMetabolic disordersTg miceT cell differentiationAdipose tissueHFD miceGrowth factorCD28 stimulationInflammatory T cell differentiationPro-inflammatory cytokines IL-6Mice fed high-fat dietType 17 helper T cellsFed high-fat dietWT-HFD miceSystemic metabolic disordersIsolated T lymphocytesHelper T cellsCytokines IL-6
2016
Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1
Jang W, Jeong J, Kim S, Kang M, Sung Y, Choi M, Park S, Kim M, Kim S, Ryoo Z. Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1. Applied Physiology Nutrition And Metabolism 2016, 41: 640-648. PMID: 27218680, DOI: 10.1139/apnm-2015-0369.Peer-Reviewed Original ResearchConceptsHigh-fat dietSAA1 levelsAmyloid depositionTg miceMetabolic disturbancesTransgenic miceHepatic serum amyloid A1Elevated levelsImpaired glucose toleranceLow-grade inflammationLocal cytokine expressionChronic inflammatory conditionsHigh-fat diet challengeSerum amyloid A1Acute phase response proteinsMajor precursor proteinCrohn's diseaseGlucose toleranceCytokine expressionInflammatory conditionsMetabolic parametersSerum amyloidMetabolic disordersAmyloid depositsDiet challenge
2013
Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet
Jang W, Bae K, Kim S, Yu D, Kim H, Ji Y, Park S, Park S, Kang M, Jeong J, Park S, Lee S, Lee I, Kim M, Yoon D, Ryoo Z. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet. Biochemical And Biophysical Research Communications 2013, 444: 296-301. PMID: 24380856, DOI: 10.1016/j.bbrc.2013.12.094.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseCarrier ProteinsCo-Repressor ProteinsDiet, High-FatDNA-Binding ProteinsGlucose Tolerance TestHomeostasisInsulinLipid MetabolismMiceMice, TransgenicNuclear ProteinsPhosphoenolpyruvate Carboxykinase (GTP)Real-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionWeight GainConceptsPutative zinc finger motifZinc finger motifsNuclear orphan receptor TR4Regulation of metabolismOverexpression of JAZF1Finger motifTranscription factorsNuclear proteinsKey enzymeExpression of JAZF1Lipid homeostasisFat dietNew therapeutic targetsWeight gainLipid accumulationManagement of obesityHigh-fat dietCritical roleJAZF1Lipid metabolismTherapeutic targetBody weight gainMetabolismRegulationDiabetes mellitus