2024
Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation
Tang S, Holle J, Mor S, Dadario N, Ryan M, Teo C, Sughrue M, Yeung J. Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation. Brain And Behavior 2024, 14: e70088. PMID: 39415644, PMCID: PMC11483549, DOI: 10.1002/brb3.70088.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderRepetitive transcranial magnetic stimulationCentral executive networkGeneralized Anxiety Disorder-7Affective disordersBeck Depression InventoryAnxiety disordersTheta burst stimulationTranscranial magnetic stimulationPittsburgh Sleep Quality IndexDorsolateral prefrontal cortexIndividualized repetitive transcranial magnetic stimulationRTMS targetsMagnetic stimulationIntermittent theta burst stimulationFunctional connectivity networksPrefrontal cortexDepressive disorderMajor depressionAffective symptomsQuality of lifeAnxiety symptomsExecutive networkDepression InventorySleep Quality IndexPersonalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept
Tang S, Holle J, Dadario N, Ryan M, Lesslar O, Teo C, Sughrue M, Yeung J. Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept. Brain Injury 2024, 38: 1015-1025. PMID: 38965876, DOI: 10.1080/02699052.2024.2371975.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationPost-concussion syndromeTraumatic brain injuryTranscranial magnetic stimulationFollow-upRivermead Post-Concussion Symptoms QuestionnaireGeneralized Anxiety Disorder-7 scorePost-Concussion Symptoms QuestionnaireRTMS targetsBeck Depression InventoryMagnetic stimulationSevere traumatic brain injuryEQ-5DNon-invasive transcranial magnetic stimulationClinically significant reductionMeasures of quality of lifeTreatment of post-concussion syndromePCS symptomsDepression InventoryRetrospective reviewOff-labelIndividual symptomsHealthy controlsPatientsControlled studiesUp-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2023
Editorial: Prevalence of pineal cysts in healthy individuals: Emphasis on size, morphology and pineal recess crowding.
Tang SJ, Yeung JT. Editorial: Prevalence of pineal cysts in healthy individuals: Emphasis on size, morphology and pineal recess crowding. J Neurol Sci 2023, 453: 120820. PMID: 37804791, DOI: 10.1016/j.jns.2023.120820.Peer-Reviewed Original ResearchPersonalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept
Tang S, Holle J, Dadario N, Lesslar O, Teo C, Ryan M, Sughrue M, Yeung J. Personalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept. Brain And Behavior 2023, 13: e3268. PMID: 37798655, PMCID: PMC10636393, DOI: 10.1002/brb3.3268.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationQuality of lifeBeck Depression InventoryTreatment-resistant depressionComorbidity of depressionMajor depressive disorderTranscranial magnetic stimulationMultiple cortical targetsDorsolateral prefrontal cortexRTMS treatmentSignificant remissionRetrospective reviewDepressive disorderPatient outcomesCortical targetsMagnetic stimulationPlacebo effectPatientsUS FoodDrug AdministrationControl groupDepression symptomsDepression InventoryFunctional connectivity networksPrefrontal cortexTopology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe
Dadario N, Tanglay O, Stafford J, Davis E, Young I, Fonseka R, Briggs R, Yeung J, Teo C, Sughrue M. Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe. Brain And Behavior 2023, 13: e2945. PMID: 36912573, PMCID: PMC10097165, DOI: 10.1002/brb3.2945.Peer-Reviewed Original ResearchConceptsActivation likelihood estimationHub-like regionsLateral occipital lobeOccipital lobeVisual networkSuperior temporal sulcusTask-based functional MRI studiesTemporal sulcusTemporo-occipital regionsFunctional MRI studyCortical parcellation schemeMeta-analytic softwareClinical significanceFunctional roleLanguage cortexMRI studiesAbnormal activationCortical regionsVisual systemFunctional coactivationCerebrumCortexPossible important roleParcellation schemesStructural connectivityConnectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity
Young I, Dadario N, Tanglay O, Chen E, Cook B, Taylor H, Crawford L, Yeung J, Nicholas P, Doyen S, Sughrue M. Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity. Journal Of Affective Disorders Reports 2023, 11: 100478. DOI: 10.1016/j.jadr.2023.100478.Peer-Reviewed Original Research
2022
Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma
Tanglay O, Dadario N, Young I, Yeung J, Teo C, Sughrue M, Yeung J. Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma. Cureus 2022, 14: e33019. PMID: 36721529, PMCID: PMC9879796, DOI: 10.7759/cureus.33019.Peer-Reviewed Original ResearchMagnetic resonance imagingCerebral artery infarctionArtery infarctionGlioma resectionGlioblastoma multiformeMiddle cerebral artery infarctionPreoperative magnetic resonance imagingCommon primary brain tumorPosterior cerebral artery infarctionAggressive cytoreductive surgeryAggressive natural historyMiddle cerebral arteryPrimary brain tumorsMost clinical researchMultivessel occlusionCytoreductive surgeryAdjuvant radiochemotherapyMedian survivalNeurologic declineOverall survivalTotal resectionVascular etiologyCerebral arteryPatient outcomesClinical guidanceNCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPT
Yeung J, Tang J, Holle J, Teo C, Sughrue M. NCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPT. Neuro-Oncology 2022, 24: vii207-vii208. DOI: 10.1093/neuonc/noac209.797.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationUpper Extremity Function ScaleLower extremity functional scaleRTMS treatmentBeck Depression InventoryNeurological disordersDepression InventoryNeuropsychiatric disordersNeuro-rehabilitationPost-operative neurological deficitsTranscranial magnetic stimulationQuality of lifeNon-significant trendMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireTumor neurosurgeryNeurological deficitsRetrospective reviewPineal cystsPrimary tumorSurgical removalTumor resectionImproving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept
Tang S, Holle J, Lesslar O, Teo C, Sughrue M, Yeung J. Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept. Journal Of Neuro-Oncology 2022, 160: 413-422. PMID: 36308593, DOI: 10.1007/s11060-022-04160-y.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationNeuro-cognitive dysfunctionRTMS treatmentBeck Depression InventoryFunctional deficitsNeurological disordersDepression InventoryPost-operative depressionTranscranial magnetic stimulationNeuro-cognitive deficitsNeuro-cognitive functionsMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireResultsNine patientsAdverse eventsRetrospective reviewSurgical removalTMS treatmentCortical targetsShort-term memory difficultiesBrain tumorsDepressive symptomsA connectivity model of the anatomic substrates underlying Gerstmann syndrome
Shahab Q, Young I, Dadario N, Tanglay O, Nicholas P, Lin Y, Fonseka R, Yeung J, Bai M, Teo C, Doyen S, Sughrue M. A connectivity model of the anatomic substrates underlying Gerstmann syndrome. Brain Communications 2022, 4: fcac140. PMID: 35706977, PMCID: PMC9189613, DOI: 10.1093/braincomms/fcac140.Peer-Reviewed Original ResearchHuman Connectome ProjectNeural networkHigher-order functionsNetworkCortical modelConnectivity modelConnectome ProjectComplex cognitive domainsRelevant regionsHCP databaseEstimation mapsCortical parcellation schemeConnectivityDomainSoftwareComputational modellingSchemeModelDatabaseInformationAnatomic informationParcellation schemesSearchAdvancement
2021
Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature
Masina R, Ansaripour A, Beneš V, Berhouma M, Choque-Velasquez J, Eide P, Fedorko S, Fleck S, Hernesniemi J, Koziarski A, Májovský M, Podgorski A, Schroeder H, Teo C, Unterberg A, Yeung J, Kolias A, Santarius T. Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature. Acta Neurochirurgica 2021, 164: 61-77. PMID: 34854993, PMCID: PMC8761144, DOI: 10.1007/s00701-021-05054-0.Peer-Reviewed Original ResearchConceptsSymptomatic pineal cystsPineal cystsCase reportCyst sizeSingle-center retrospective cohortChronic incisional painLarger cyst sizeRetrospective surgical seriesOverall complication rateRole of surgeryVertigo/dizzinessMean cyst sizeLoss of consciousnessObjective outcome assessmentNausea/vomitSupracerebellar infratentorial approachAssessment of outcomesMajority of casesIncisional painComplication rateFocal neurologyGait disturbanceMost patientsPatient characteristicsRetrospective cohortChanges in the Brain Connectome Following Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation
Yeung J, Young I, Doyen S, Teo C, Sughrue M, Yeung J. Changes in the Brain Connectome Following Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation. Cureus 2021, 13: e19105. PMID: 34858752, PMCID: PMC8614179, DOI: 10.7759/cureus.19105.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationIntermittent theta burst stimulationPost-stroke patientsTranscranial magnetic stimulationMagnetic stimulationUse of rTMSUpper extremity motor functionExtremity motor functionUpper extremity functionTheta burst stimulationPost-stroke rehabilitationIschemic strokeRTMS treatmentMotor thresholdExtremity functionMedical historyMotor functionPhysical therapyBurst stimulationSensorimotor networkStroke rehabilitationNeural changesSpeech therapyConnectomic changesConnectomic analysisReducing the Cognitive Footprint of Brain Tumor Surgery
Dadario NB, Brahimaj B, Yeung J, Sughrue ME. Reducing the Cognitive Footprint of Brain Tumor Surgery. Frontiers In Neurology 2021, 12: 711646. PMID: 34484105, PMCID: PMC8415405, DOI: 10.3389/fneur.2021.711646.Peer-Reviewed Original ResearchOnco-functional balanceCognitive morbidityCortical regionsNew neurologic deficitsRate of resectionExtent of resectionBrain tumor surgeryHuman Connectome ProjectNeurologic deficitsSurgical managementPatient outcomesCortical mappingMotor functionTumor surgeryGlioma patientsStructural neuroanatomyInvasive techniquesBrain tumorsCerebral surgerySurgical armamentariumConnectomic dataEloquent tissueHigher-order cognitive functionsCognitive functionSurgeryUsing Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept
Yeung JT, Taylor HM, Nicholas PJ, Young IM, Jiang I, Doyen S, Sughrue ME, Teo C. Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept. World Neurosurgery 2021, 154: e734-e742. PMID: 34358688, DOI: 10.1016/j.wneu.2021.07.127.Peer-Reviewed Original ResearchConceptsIntracerebral surgeryNeurologic deficitsNew postoperative neurologic deficitsCases of leukoencephalopathyNew neurologic deficitsHigh-risk patientsPostoperative neurologic deficitsPostoperative neurologic outcomeIntra-axial tumorsFunctional localizationBrain networksEarlier retrospective studiesCritical brain networksDefault mode networkPostoperative strokeNeurologic outcomeMedian ageNeurological deficitsPreoperative findingsNew deficitsRetrospective studyPostsurgical outcomesIntracranial surgeryNeuronavigation platformStandard neuronavigationOptimal timing of post-operative enoxaparin after neurosurgery: A single institution experience
Briggs RG, Lin YH, Dadario NB, Young IM, Conner AK, Xu W, Tanglay O, Kim SJ, Fonseka RD, Bonney PA, Chakraborty AR, Nix CE, Flecher LR, Yeung JT, Teo C, Sughrue ME. Optimal timing of post-operative enoxaparin after neurosurgery: A single institution experience. Clinical Neurology And Neurosurgery 2021, 207: 106792. PMID: 34233235, DOI: 10.1016/j.clineuro.2021.106792.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisLower extremity deep vein thrombosisExtremity deep vein thrombosisIntracranial tumor resectionVenous thromboembolismAnticoagulant prophylaxisProphylactic enoxaparinTumor resectionImmediate post-operative periodMultivariate binomial logistic regression analysisNon-anticoagulation groupSingle institution experiencePost-operative periodPossible risk factorsPost-operative brain tumor patientsEvidence-based protocolsBrain tumor patientsLogistic regression analysisHigh-grade gliomasBinomial logistic regression analysisVTE complicationsElective craniotomyMedical comorbiditiesPulmonary embolismAdult patientsA connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studies
O'Neal CM, Ahsan SA, Dadario NB, Fonseka RD, Young IM, Parker A, Maxwell BD, Yeung JT, Briggs RG, Teo C, Sughrue ME. A connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studies. Clinical Neurology And Neurosurgery 2021, 207: 106765. PMID: 34237682, DOI: 10.1016/j.clineuro.2021.106765.Peer-Reviewed Original ResearchTargeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas
Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Neuro-Oncology 2021, 23: 1922-1935. PMID: 33914067, PMCID: PMC8563319, DOI: 10.1093/neuonc/noab075.Peer-Reviewed Original ResearchConceptsColony-stimulating factor-1Myeloid cellsMalignant meningiomasTumor microenvironmentCSF1/CSF1RRNA-seqRNA sequencingHuman meningiomasImmune subsetsGene expressionT cellsTreatment strategiesNormalization cancer immunotherapyImportant regulatorCell typesNovel immunocompetent murine modelDeath ligand 1 (PD-L1) expressionCell death receptor-1Immunosuppressive myeloid cellsDeath receptor-1Ligand 1 expressionFactor 1Immune cell typesImmunocompetent murine modelEffective treatment strategiesResection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned
Yeung JT, Young IM, Profyris C, Katsos K, Sughrue ME, Teo C. Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned. World Neurosurgery 2021, 150: e668-e674. PMID: 33771749, DOI: 10.1016/j.wneu.2021.03.087.Peer-Reviewed Original ResearchConceptsSymptomatic pineal cystsPineal cystsSurgical resectionClinical improvementDurable clinical improvementExhaustive conservative managementNon-headache symptomsDurable symptomatic reliefYears of agePresenting symptomConservative managementSymptomatic patientsSurgical candidacySymptomatic reliefVisual disturbancesClinical outcomesPatient populationRadiographic changesCerebral aqueductRetrospective analysisResectionPatientsVariable symptomsCystsHeadacheAggressive Progression of a WHO Grade I Meningioma of the Posterior Clinoid Process: An Illustration of the Risks Associated With Observation of Skull Base Meningiomas
Young IM, Yeung J, Glenn C, Teo C, Sughrue ME. Aggressive Progression of a WHO Grade I Meningioma of the Posterior Clinoid Process: An Illustration of the Risks Associated With Observation of Skull Base Meningiomas. Cureus 2021, 13: e14005. PMID: 33884246, PMCID: PMC8054942, DOI: 10.7759/cureus.14005.Peer-Reviewed Original ResearchGrade I meningiomasI meningiomasSurveillance magnetic resonance imagingWorld Health Organization (WHO) grade I meningiomasSubstantial neurological deficitsSkull base meningiomasPosterior clinoid processMagnetic resonance imagingExpectant managementFurther surgeryNeurological deficitsSurgical resectionHistopathological confirmationResidual tumorAggressive progressionGrade ISmall meningiomasClinoid processClinoid meningiomasResonance imagingMeningiomasTumorsPrecarious locationPotential pitfallsResection