Featured Publications
Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition
Chernova I, Craft J. Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition. Cell Reports Medicine 2021, 2: 100479. PMID: 35028618, PMCID: PMC8714907, DOI: 10.1016/j.xcrm.2021.100479.Peer-Reviewed Original ResearchThe ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase
2024
Lupus Nephritis: Immune Cells and the Kidney Microenvironment
Chernova I. Lupus Nephritis: Immune Cells and the Kidney Microenvironment. Kidney360 2024, 5: 1394-1401. PMID: 39120952, PMCID: PMC11441818, DOI: 10.34067/kid.0000000000000531.Peer-Reviewed Original ResearchIntrinsic renal cellsLupus nephritisImmune cellsRenal cellsProgression to end-stage kidney diseaseActivation of immune cellsProinflammatory cytokine milieuSystemic immunosuppressive effectsAutoimmune disease systemic lupus erythematosusDisease systemic lupus erythematosusImmune cell activationSystemic lupus erythematosusEnd-stage kidney diseaseLN therapyCytokine milieuKidney cell functionImmune infiltrationKidney microenvironmentOrgan manifestationsLupus erythematosusAntigen presentationCytokine productionImmunosuppressive effectsKidney diseaseCell activation
2022
The Ion Transporter Na+-K+-ATPase Enables Pathological B Cell Survival in the Kidney Microenvironment of Lupus Nephritis
Chernova I, Craft J. The Ion Transporter Na+-K+-ATPase Enables Pathological B Cell Survival in the Kidney Microenvironment of Lupus Nephritis. Journal Of The American Society Of Nephrology 2022, 33: 486-487. DOI: 10.1681/asn.20223311s1486d.Peer-Reviewed Original Research