2024
Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12: rp87529. PMID: 38700991, PMCID: PMC11068354, DOI: 10.7554/elife.87529.Peer-Reviewed Original ResearchConceptsDose of ketamineAntidepressant effectsKetamine's antidepressant actionPotential antidepressant effectsRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effects
2013
Cortical Signals for Rewarded Actions and Strategic Exploration
Donahue CH, Seo H, Lee D. Cortical Signals for Rewarded Actions and Strategic Exploration. Neuron 2013, 80: 223-234. PMID: 24012280, PMCID: PMC3792491, DOI: 10.1016/j.neuron.2013.07.040.Peer-Reviewed Original Research
2009
Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game
Seo H, Barraclough DJ, Lee D. Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game. Journal Of Neuroscience 2009, 29: 7278-7289. PMID: 19494150, PMCID: PMC2743508, DOI: 10.1523/jneurosci.1479-09.2009.Peer-Reviewed Original ResearchBehavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers
Seo H, Lee D. Behavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers. Journal Of Neuroscience 2009, 29: 3627-3641. PMID: 19295166, PMCID: PMC2750005, DOI: 10.1523/jneurosci.4726-08.2009.Peer-Reviewed Original ResearchConceptsFrontal cortexDorsomedial frontal cortexBehavioral effectsConditioned reinforcersDorsal anterior cingulate cortexAnterior cingulate cortexMedial frontal cortexDorsolateral prefrontal cortexCingulate cortexNeural changesRhesus monkeysNeural effectsCortexPrefrontal cortexPrevious trialsSubsequent trialsNeural mechanisms
2007
Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game
Seo H, Lee D. Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game. Journal Of Neuroscience 2007, 27: 8366-8377. PMID: 17670983, PMCID: PMC2413179, DOI: 10.1523/jneurosci.2369-07.2007.Peer-Reviewed Original Research