Featured Publications
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation
Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports 2017, 20: 721-736. PMID: 28723573, PMCID: PMC5626450, DOI: 10.1016/j.celrep.2017.06.074.Peer-Reviewed Original ResearchConceptsCell cycleCancer-related metabolic pathwaysAmino acid synthesisUpregulation of glycolysisNormal proliferative cellsCellular transitionsMetabolic machineryOxidative phosphorylationLymphocyte cell linesEssential amino acidsMetabolic pathwaysAmino acidsNucleotide synthesisCancer cellsCell linesProteomicsMetabolomic characterizationIL-3Proliferative cellsLipid metabolismUrea cycleCellsMetabolic changesMetabolomic profilingPotential link
2019
Reprogramming of Colonic Cell Metabolism by H2S
Vitvitsky V, Libiad M, Bostelaar T, Maebius A, Lee H, Lyssiotis C, Banerjee R. Reprogramming of Colonic Cell Metabolism by H2S. The FASEB Journal 2019, 33: 485.11-485.11. DOI: 10.1096/fasebj.2019.33.1_supplement.485.11.Peer-Reviewed Original ResearchOxygen consumption rateMitochondrial sulfide oxidation pathwayNumerous protein targetsSulfide oxidation pathwayEnergy metabolism pathwaysColon cancer tissuesMetabolic reprogrammingHuman colonic cellsInhibition of respirationProtein targetsStress responseNon-malignant cellsReductive carboxylationCell metabolismMetabolism pathwaysGrowth advantageInhibition of proliferationFASEB JournalCell exposurePathwayFull-text articlesColonic cellsGut microbiotaRespiratory toxinsCells