2024
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original Research
2023
Global sonication of the human intracranial space via a jumbo planar transducer
Brinker S, Yoon K, Benveniste H. Global sonication of the human intracranial space via a jumbo planar transducer. Ultrasonics 2023, 134: 107062. PMID: 37343366, DOI: 10.1016/j.ultras.2023.107062.Peer-Reviewed Original ResearchConceptsPlanar transducerAcoustic intensityUltrasound beamAcoustic wave reflectionFocused ultrasound beamHuman skull specimensTherapeutic ultrasound applicationsElectrical powerSpatial-peak pulse-average intensityField uniformityTransmission lossField characterizationWave behaviorUltrasound applicationWave reflectionPulse average intensityTreatment envelopeComputational simulationsUltrasound energyPulse parametersStimulation regionSimulationsBeamLens effectTransducer
2022
CSF-to-dura gateways
Thomas J, Benveniste H. CSF-to-dura gateways. Journal Of Experimental Medicine 2022, 220: e20221719. PMID: 36472584, PMCID: PMC9729850, DOI: 10.1084/jem.20221719.Peer-Reviewed Original Research
2008
Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"
Djurić P, Benveniste H, Wagshul M, Henn F, Enikolopov G, Maletić-Savatić M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain". Science 2008, 321: 640-640. PMID: 26380846, PMCID: PMC4576718, DOI: 10.1126/science.1156889.Peer-Reviewed Original ResearchMetabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery
Maletić-Savatić M, Vingara L, Manganas L, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul M, Henn F, Krupp L, Enikolopov G, Benveniste H, Djurić P, Pelczer I. Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery. Cold Spring Harbor Symposia On Quantitative Biology 2008, 73: 389-401. PMID: 19022759, PMCID: PMC4037147, DOI: 10.1101/sqb.2008.73.021.Peer-Reviewed Original ResearchConceptsNeural stem/progenitor cellsFunctional insightsProgenitor cellsStem/progenitor cellsNeural progenitor cellsBiomarker discoveryGenome backgroundHuman neurological diseasesLive human brainSystems metabolomicsMammalian brainVivo analysisSpecific metabolitesMetabolomics techniquesMost neurological disordersLack of biomarkersEarly pathological processesProton magnetic resonance spectroscopyOrganismsMetabolomicsPathological processesHuman brainNPC biomarkersCellsLate therapy
1999
Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy
Benveniste H, Einstein G, Kim K, Hulette C, Johnson G. Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14079-14084. PMID: 10570201, PMCID: PMC24193, DOI: 10.1073/pnas.96.24.14079.Peer-Reviewed Original ResearchAnxiety, vocalization, and agitation following peripheral nerve block with ropivacaine
Klein S, Benveniste H. Anxiety, vocalization, and agitation following peripheral nerve block with ropivacaine. Regional Anesthesia & Pain Medicine 1999, 24: 175-178. PMID: 10204906, DOI: 10.1016/s1098-7339(99)90081-0.Peer-Reviewed Case Reports and Technical NotesConceptsCentral nervous systemLocal anesthetics-induced toxicityAnesthetic-induced toxicityPeripheral nerve blockadePeripheral nerve blocksAdministration of ropivacainePotential side effectsMediation of anxietyCNS toxicityNerve blockNerve blockadeCardiovascular toxicityCase reportClassical signsLocal anestheticsRopivacaineSide effectsUnusual symptomsNervous systemNeural pathwaysUnexpected behavioral changesCardiovascular systemHuman volunteersVerbal commandsPatientsAnxiety, Vocalization, and Agitation Following Peripheral Nerve Block With Ropivacaine
Klein S, Benveniste H. Anxiety, Vocalization, and Agitation Following Peripheral Nerve Block With Ropivacaine. Regional Anesthesia & Pain Medicine 1999, 24: 175-178. DOI: 10.1097/00115550-199924020-00014.Peer-Reviewed Case Reports and Technical NotesConceptsCentral nervous systemLocal anesthetics-induced toxicityAnesthetic-induced toxicityPeripheral nerve blockadePeripheral nerve blocksAdministration of ropivacainePotential side effectsMediation of anxietyCNS toxicityNerve blockNerve blockadeCase reportCardiovascular toxicityClassical signsLocal anestheticsRopivacaineSide effectsUnusual symptomsNervous systemNeural pathwaysUnexpected behavioral changesCardiovascular systemHuman volunteersVerbal commandsPatients
1998
Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons
Scotland P, Zhou D, Benveniste H, Bennett V. Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons. Journal Of Cell Biology 1998, 143: 1305-1315. PMID: 9832558, PMCID: PMC2133070, DOI: 10.1083/jcb.143.5.1305.Peer-Reviewed Original ResearchConceptsNervous systemOptic nervePyramidal tractCorpus callosumOptic nerve axonsPostnatal day 21Long fiber tractsPostnatal day 1Postnatal day 7Mouse nervous systemNervous system defectsL1 miceCell adhesion molecule L1Internal capsuleSpinal cordAdhesion molecule L1Extensive degenerationCell adhesion moleculeLateral columnDay 1Day 21Day 7Human patientsL1 mutationsDay 20
1997
Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b
JOHNSON G, BENVENISTE H, ENGELHARDT R, QIU H, HEDLUND L. Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b. Annals Of The New York Academy Of Sciences 1997, 820: 139-148. PMID: 9237453, DOI: 10.1111/j.1749-6632.1997.tb46193.x.Peer-Reviewed Original Research
1992
Direct digitization of optical images using a photostimulable phosphor system
Dobbins J, Chotas H, Benveniste H. Direct digitization of optical images using a photostimulable phosphor system. Medical Physics 1992, 19: 1071-1080. PMID: 1518470, DOI: 10.1118/1.596917.Peer-Reviewed Original ResearchConceptsOptical imagesX-ray imaging propertiesX-ray fieldOptical density responsePhosphor systemPhotostimulable phosphor systemHigh optical densityOptical techniquesIncident lightSpatial frequency responseTransparent objectsImaging propertiesSpatial uniformityDensity responseFourier filteringOptical densityProjection techniqueDirect digitizationFrequency responseTable correctionLow densityDensityImage noiseSpatial enhancementLight
1991
The excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1990
Microdialysis—Theory and application
Benveniste H, Hüttemeier P. Microdialysis—Theory and application. Progress In Neurobiology 1990, 35: 195-215. PMID: 2236577, DOI: 10.1016/0301-0082(90)90027-e.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements