2024
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original ResearchUnbalanced regularized optimal mass transport with applications to fluid flows in the brain
Chen X, Benveniste H, Tannenbaum A. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain. Scientific Reports 2024, 14: 1111. PMID: 38212659, PMCID: PMC10784574, DOI: 10.1038/s41598-023-50874-y.Peer-Reviewed Original ResearchConceptsFluid flowMass transportEntire transport processNumerical solution procedureKinetic energyTotal kinetic energyImage trackingSolution procedureOptimal mass transportTransport processesMass transport approachTransport problemsMass configurationConstraint equationsFlowTransport approachApplicationsBenamouFormulationTransportTracking
2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRatsGlobal sonication of the human intracranial space via a jumbo planar transducer
Brinker S, Yoon K, Benveniste H. Global sonication of the human intracranial space via a jumbo planar transducer. Ultrasonics 2023, 134: 107062. PMID: 37343366, DOI: 10.1016/j.ultras.2023.107062.Peer-Reviewed Original ResearchConceptsPlanar transducerAcoustic intensityUltrasound beamAcoustic wave reflectionFocused ultrasound beamHuman skull specimensTherapeutic ultrasound applicationsElectrical powerSpatial-peak pulse-average intensityField uniformityTransmission lossField characterizationWave behaviorUltrasound applicationWave reflectionPulse average intensityTreatment envelopeComputational simulationsUltrasound energyPulse parametersStimulation regionSimulationsBeamLens effectTransducerActivation of brain arousal networks coincident with eye blinks during resting state.
Demiral Ş, Kure Liu C, Benveniste H, Tomasi D, Volkow N. Activation of brain arousal networks coincident with eye blinks during resting state. Cerebral Cortex 2023, 33: 6792-6802. PMID: 36653022, PMCID: PMC10233245, DOI: 10.1093/cercor/bhad001.Peer-Reviewed Original Research
2008
Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"
Djurić P, Benveniste H, Wagshul M, Henn F, Enikolopov G, Maletić-Savatić M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain". Science 2008, 321: 640-640. PMID: 26380846, PMCID: PMC4576718, DOI: 10.1126/science.1156889.Peer-Reviewed Original Research
2007
Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays
Anschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays. Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.Peer-Reviewed Original ResearchConceptsT2 signalCentral nervous system diseaseHigh T2 signalNervous system diseasesTesla magnetic resonance imagingFocal brain lesionsMagnetic resonance imagingBrain lesionsRadiosurgical approachRat brainSystem diseasesStereotactic radiosurgeryHigh-dose irradiationFuture treatmentLow dosesLesionsResonance imagingLow T1Dose irradiationBrainTreatmentPrecise targetsX-ray
2005
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy
Ma Y, Hof P, Grant S, Blackband S, Bennett R, Slatest L, McGuigan M, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience 2005, 135: 1203-1215. PMID: 16165303, DOI: 10.1016/j.neuroscience.2005.07.014.Peer-Reviewed Original Research
2001
Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study
McDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study. NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtrophyBrainBrain IschemiaBrain MappingCerebral VentriclesDisease Models, AnimalHippocampusImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, Neurologic MutantsMicroscopyNeurodegenerative DiseasesProsencephalonConceptsApoE-deficient miceModels of neurodegenerationPostischemic dayBrain atrophyMouse modelNeurodegenerative diseasesDorsal hippocampal volumeBrain volume changesMin of ischemiaHigh signal intensity areaTransgenic mouse modelProgression of pathologyCorresponding time pointsSignal intensity areaMagnetic resonance imagingHigh-resolution MRIT1-weighted MR imagingC57 miceDorsal hippocampusHippocampal volumeClinical conditionsIschemiaMRI studiesPredetermined protocolCognitive declineProgress in high field MRI at the University of Florida
Beck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida. Magnetic Resonance Materials In Physics, Biology And Medicine 2001, 13: 152-157. PMID: 11755090, PMCID: PMC3363288, DOI: 10.1007/bf02678590.Peer-Reviewed Original Research
2000
Magnetic Resonance Microscopy of the C57BL Mouse Brain
Benveniste H, Kim K, Zhang L, Johnson G. Magnetic Resonance Microscopy of the C57BL Mouse Brain. NeuroImage 2000, 11: 601-611. PMID: 10860789, DOI: 10.1006/nimg.2000.0567.Peer-Reviewed Original ResearchCerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1998
Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons
Scotland P, Zhou D, Benveniste H, Bennett V. Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons. Journal Of Cell Biology 1998, 143: 1305-1315. PMID: 9832558, PMCID: PMC2133070, DOI: 10.1083/jcb.143.5.1305.Peer-Reviewed Original ResearchConceptsNervous systemOptic nervePyramidal tractCorpus callosumOptic nerve axonsPostnatal day 21Long fiber tractsPostnatal day 1Postnatal day 7Mouse nervous systemNervous system defectsL1 miceCell adhesion molecule L1Internal capsuleSpinal cordAdhesion molecule L1Extensive degenerationCell adhesion moleculeLateral columnDay 1Day 21Day 7Human patientsL1 mutationsDay 20
1997
Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study
Qiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study. Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryStroke volumeIpsilateral common carotid arteryReduced stroke volumeFocal ischemic lesionsCommon carotid arteryGlycine/NMDA antagonistsMCA occlusionCerebral arteryIschemic lesionsMultiple time pointsNMDA antagonistsCarotid arteryDrug treatmentRat brainGroup 2Group 1Control groupVivo studiesTime pointsZD9379ArteryOcclusionHoursTreatmentMagnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b
JOHNSON G, BENVENISTE H, ENGELHARDT R, QIU H, HEDLUND L. Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b. Annals Of The New York Academy Of Sciences 1997, 820: 139-148. PMID: 9237453, DOI: 10.1111/j.1749-6632.1997.tb46193.x.Peer-Reviewed Original Research
1992
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1991
MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow
Maki J, Benveniste H, Macfall J, Piantadosi C, Johnson G. MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow. Journal Of Magnetic Resonance Imaging 1991, 1: 673-681. PMID: 1823172, DOI: 10.1002/jmri.1880010609.Peer-Reviewed Original ResearchConceptsCerebral blood flowRat cerebral blood flowBlood flowArterial carbon dioxide pressureLaser Doppler flowmetry studyMR imaging studiesMagnetic resonance imaging techniquesRat brainLDF valuesCarbon dioxide pressureImaging studiesMR imagingTissue microcirculationImaging valuesPaCO2MicrocirculationQualitative pictureMotion sensitivityPresent studyCarbon dioxide-induced changeImaging techniquesFC techniqueRat motionsGradient coilsImagingDecreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose
Hilgier W, Benveniste H, Diemer N, Albrecht J. Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose. Acta Neurologica Scandinavica 1991, 83: 353-355. PMID: 1887755, DOI: 10.1111/j.1600-0404.1991.tb03961.x.Peer-Reviewed Original ResearchConceptsBrain regionsLocal cerebral metabolic rateCerebral metabolic rateDiscrete brain regionsHepatic encephalopathyParticular brain regionsCerebral cortexGlutamatergic neuronsGlutamatergic neurotransmissionMedulla oblongataAuditory cortexGlucose utilizationDeoxyglucose uptakeBioenergetic failureEnergy metabolismRatsCortexPossible linkMetabolic ratePossible contributionThioacetamideOblongataEncephalopathyHippocampusStriatumDiffusion/microcirculation MRI in the rat brain
Macfall J, Maki J, Johnson G, Hedlund L, Benveniste H, Copher G. Diffusion/microcirculation MRI in the rat brain. Magnetic Resonance In Medicine 1991, 19: 305-310. PMID: 1908936, DOI: 10.1002/mrm.1910190219.Peer-Reviewed Original ResearchQuantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid artery