2024
Surgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis
Grubman D, Lansky A, Dwyer M, Zivadinov R, Pietras C, Nazif T, Moses J, Shah T, Gambone L, Leon M, Forrest J, Vora A, Parise H, Messé S. Surgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis. Cardiovascular Revascularization Medicine 2024, 65: 80. DOI: 10.1016/j.carrev.2024.04.179.Peer-Reviewed Original ResearchClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisCo-Morbidity Differences Associated With Long-Term Amputation and Repeat Revascularization Rates After Femoropopliteal Artery Intervention for Intermittent Claudication by Sex, Race, and Ethnicity
Altin S, Parise H, Hess C, Rosenthal N, Julien H, Curtis J. Co-Morbidity Differences Associated With Long-Term Amputation and Repeat Revascularization Rates After Femoropopliteal Artery Intervention for Intermittent Claudication by Sex, Race, and Ethnicity. The American Journal Of Cardiology 2024, 226: 40-49. PMID: 38834142, DOI: 10.1016/j.amjcard.2024.05.021.Peer-Reviewed Original ResearchNon-Hispanic patientsHispanic patientsIntermittent claudicationPeripheral vascular interventionsBlack patientsWhite patientsAmputation rateIndex limb amputationHazard ratioCox proportional hazards regression modelsDisease-specific issuesProportional hazards regression modelsHazards regression modelsBaseline characteristicsLimb amputationMajor amputationUnadjusted ratesAssociated with higher ratesHealthcare databasesBlack raceSecondary outcomesPrimary outcomeAmputationRevascularization ratesComparison groupDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresEffect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Kandzari D, Weber M, Pathak A, Zidar J, Saxena M, David S, Schmieder R, Janas A, Langer C, Persu A, Mendelsohn F, Ameloot K, Foster M, Fischell T, Parise H, Mahfoud F. Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial. Circulation 2024, 149: 1875-1884. PMID: 38587557, DOI: 10.1161/circulationaha.124.069291.Peer-Reviewed Original ResearchSystolic blood pressureOffice systolic blood pressureRenal denervationOffice diastolic BPAmbulatory systolic BPBlood pressureSham controlsPrimary endpointBetween-group differencesNo significant differenceAntihypertensive medicationsDiastolic BPSystolic BPPresence of antihypertensive medicationBaseline-adjusted changeRenal artery dissectionMonths post-procedureSignificant differenceRenal denervation groupAmbulatory systolic blood pressureNo significant between-group differencesStatistically significant reductionSignificant between-group differencesSecondary endpointsOffice BPPREDICTORS AND CONSEQUENCES OF BRAIN INJURY VOLUME BY DIFFUSION-WEIGHTED MRI FOLLOWING TAVR
Grubman D, Dwyer M, Lansky A, Zivadinov R, Pietras C, Nazif T, Moses J, Shah T, Gambone L, Parise H, Messe S. PREDICTORS AND CONSEQUENCES OF BRAIN INJURY VOLUME BY DIFFUSION-WEIGHTED MRI FOLLOWING TAVR. Journal Of The American College Of Cardiology 2024, 83: 970. DOI: 10.1016/s0735-1097(24)02960-7.Peer-Reviewed Original ResearchSAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Tirziu D, Saleh A, Huang H, Akhlaghi N, Breen T, Parikh S, Rosenfield K, Armstrong E, Geraghty P, Brodmann M, Adams G, Snyder D, Zilinyi R, Altin S, Parise H, Lansky A. SAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Journal Of The American College Of Cardiology 2024, 83: 843. DOI: 10.1016/s0735-1097(24)02833-x.Peer-Reviewed Original Research800.09 Surgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis
Grubman D, Lansky A, Dwyer M, Zivadinov R, Pietras C, Nazif T, Moses J, Shah T, Gambone L, Leon M, Forrest J, Vora A, Parise H, Messé S. 800.09 Surgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis. JACC Cardiovascular Interventions 2024, 17: s67-s68. DOI: 10.1016/j.jcin.2024.01.234.Peer-Reviewed Original Research
2023
Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study
Grubman D, Ahmad Y, Leipsic J, Blanke P, Pasupati S, Webster M, Nazif T, Parise H, Lansky A. Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study. The American Journal Of Cardiology 2023, 207: 28-34. PMID: 37722198, DOI: 10.1016/j.amjcard.2023.08.137.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementAtrial fibrillationHuman studiesEmbolic protection device useHigh embolic riskPrimary end pointHigh-risk patientsIndependent core laboratorySelf-expanding valvesComputed tomography angiographyProtection device useCerebral embolizationCerebrovascular eventsEmbolic riskAcute thrombusEmbolic burdenAngiography featuresTechnical successTomography angiographyEmbolic debrisValve useCore laboratoryEnd pointAlcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washoutSupervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis
Kapadia S, Huang H, Parise H, Ismayl M, Ahmed Z, Tirziu D, Altin S. Supervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2023, 205: 403-405. PMID: 37659260, DOI: 10.1016/j.amjcard.2023.08.044.Peer-Reviewed Original ResearchEffect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement
Shah T, Maarek R, See C, Huang H, Wang Y, Parise H, Forrest J, Lansky A. Effect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement. Cardiovascular Revascularization Medicine 2023, 59: 3-8. PMID: 37573173, DOI: 10.1016/j.carrev.2023.07.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationConduction disturbancesPrimary endpointStatin usersPacemaker placementRate of AFTranscatheter aortic valve replacementNew atrial fibrillationNew conduction disturbancesPersistent conduction disturbancesAortic valve replacementLong-term prognosisSmall retrospective studiesSignificant differencesPrior pacemakerIndex hospitalizationIntensity statinsValve replacementConsecutive patientsPropensity matchingProcedural complicationsStatin regimenRetrospective studyStatin usageCardiac proceduresLong-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication
Altin S, Parise H, Hess C, Rosenthal N, Creager M, Aronow H, Curtis J. Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovascular Interventions 2023, 16: 1668-1678. PMID: 37438035, DOI: 10.1016/j.jcin.2023.05.001.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsIndex limb amputationAmputation rateIntermittent claudicationMajor amputationRevascularization ratesVascular interventionsCox proportional hazards regressionLong-term patient outcomesMajor amputation rateProportional hazards regressionKaplan-Meier estimatesFurther risk factorsLimb amputation rateClinical trial dataIndex limbIC patientsSecondary outcomesPrimary outcomeHazards regressionRisk factorsPatient outcomesLimb amputationHealthcare databasesPatientsChocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study.
Böhme T, Zeller T, Shishehbor M, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh S, Kashyap V, Pietras C, Tirziu D, Beschorner U, Krishnan P, Niazi K, Wali A, Lansky A. Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study. Journal Of Endovascular Therapy 2023, 15266028231179589. PMID: 37314243, DOI: 10.1177/15266028231179589.Peer-Reviewed Original ResearchLutonix drug-coated balloonDrug-coated balloonsPrimary safety endpointDM statusFemoropopliteal diseaseDiabetes mellitusSafety endpointFemoropopliteal lesionsSimilar safetyHigh-risk patient populationFemoropopliteal artery lesionsIschemic rest painNon-DM patientsSymptomatic femoropopliteal lesionsPrimary efficacy endpointMajor adverse eventsTherapy of choiceDrug-Coated BalloonMajor amputationRest painEfficacy endpointPrimary patencyAdverse eventsArtery lesionsDiabetes statusImpact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGCerebral Embolic Risk in Coronary and Structural Heart Interventions: Clinical Evidence
Tirziu D, Huang H, Parise H, Pietras C, Moses J, Messé S, Lansky A. Cerebral Embolic Risk in Coronary and Structural Heart Interventions: Clinical Evidence. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100631. PMID: 39130705, PMCID: PMC11307836, DOI: 10.1016/j.jscai.2023.100631.Peer-Reviewed Original ResearchStructural heart interventionsHeart interventionsCardiac proceduresBrain injuryLong-term neurocognitive sequelaeTranscatheter aortic valve replacement (TAVR) proceduresAortic valve replacement proceduresCerebral embolic riskIatrogenic brain injuryIschemic brain injuryRisk of thromboembolismCoronary artery diseaseEmbolic protection devicesNumber of patientsValve replacement proceduresPercutaneous transcatheter interventionsLikelihood of disabilitySymptomatic strokeCerebral embolismCerebral embolizationEmbolic riskAcute strokeNeurologic injuryArtery diseaseIschemic infarctionColchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial
Shah T, McCarthy M, Nasir I, Archer H, Ragheb E, Kluger J, Kashyap N, Paredes C, Patel P, Lu J, Kandel P, Song C, Khan M, Huang H, Haq F, Ahmad R, Howes C, Cambi B, Lancaster G, Cleman M, Dela Cruz C, Parise H, Lansky A. Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial. BMJ Open 2023, 13: e067910. PMID: 36828654, PMCID: PMC9971831, DOI: 10.1136/bmjopen-2022-067910.Peer-Reviewed Original ResearchConceptsStandard of careHigh-intensity rosuvastatinElectronic medical recordsCOVID-19 diseaseMedical recordsPrimary endpointThromboembolic eventsYale New Haven Health SystemSevere COVID-19 diseaseCOVID-19Prespecified primary endpointVenous thromboembolic eventsRisk of progressionCombination of colchicineSafety monitoring boardCare armHispanics/LatinosTherapeutic anticoagulationIndex hospitalisationIll patientsMedian ageFuture trialsEffect of colchicineClinical trialsMonitoring board
2022
Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis
Lansky AJ, Tirziu D, Moses JW, Pietras C, Ohman EM, O'Neill WW, Ekono MM, Grines CL, Parise H. Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis. The American Journal Of Cardiology 2022, 185: 29-36. PMID: 36210212, DOI: 10.1016/j.amjcard.2022.08.032.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionAcute kidney injuryCardiogenic shockMyocardial infarctionIABP supportKidney injuryBalloon pumpImproved survivalPropensity adjustmentAcute ST-elevation myocardial infarctionST-elevation myocardial infarctionIndex hospitalization lengthLess myocardial infarctionPremier Healthcare DatabaseHospital myocardial infarctionPropensity-adjusted analysisMechanical circulatory supportMechanical support devicesImpella useHospital survivalIndex hospitalizationCoronary interventionReal-world practiceCoronary Orbital Atherectomy in Patients With Severe Aortic Stenosis.
Donatelle M, Agasthi P, Parise H, Igyarto Z, Martinsen B, Leon M, Beohar N. Coronary Orbital Atherectomy in Patients With Severe Aortic Stenosis. Journal Of Invasive Cardiology 2022, 34: e696-e700. PMID: 36200995.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisNon-AS cohortAortic stenosisNon-AS patientsSuccessful stent placementOrbital atherectomyStent placementOA useHospital major adverse cardiovascular eventsSevere calcific coronary artery diseaseCalcific coronary artery diseaseConcomitant severe aortic stenosisMajor adverse cardiovascular eventsCoronary orbital atherectomyIdeal revascularization strategyAdverse cardiovascular eventsMount Sinai Medical CenterProspective randomized trialsGlomerular filtration rateCoronary artery diseaseSinai Medical CenterPaucity of dataAngiographic complicationsMACE rateCardiovascular eventsCoronary Orbital Atherectomy Treatment of Hispanic and Latino Patients: A Real-World Comparative Analysis
Beohar N, Stone G, Martinsen B, Parise H, Vinardell J, Heimowitz T, Koelbl C, Leon M, Kirtane A. Coronary Orbital Atherectomy Treatment of Hispanic and Latino Patients: A Real-World Comparative Analysis. Cardiovascular Revascularization Medicine 2022, 40: 14. DOI: 10.1016/j.carrev.2022.06.021.Peer-Reviewed Original Research