2014
Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7
Wu Z, Mirza H, Tan KS. Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7. PLOS Neglected Tropical Diseases 2014, 8: e2885. PMID: 24851944, PMCID: PMC4031124, DOI: 10.1371/journal.pntd.0002885.Peer-Reviewed Original ResearchConceptsEpithelial barrier disruptionBarrier disruptionDrug resistanceBlastocystis subtype 7Intra-subtype variationOccludin tight junction proteinsEpithelial barrier dysfunctionDiverse clinical outcomesParasite virulence factorsTight junction proteinsCaco-2 cellsClinical outcomesBarrier dysfunctionIntestinal disordersMetronidazole resistanceBlastocystis infectionSubtype 7Metronidazole susceptibilityHost responseIntestinal epitheliumEnteric pathogensNitrosative stressResistant strainsJunction proteinsLuminal stages
2010
Current Views on the Clinical Relevance of Blastocystis spp.
Tan KS, Mirza H, Teo JD, Wu B, MacAry PA. Current Views on the Clinical Relevance of Blastocystis spp. Current Infectious Disease Reports 2010, 12: 28-35. PMID: 21308496, DOI: 10.1007/s11908-009-0073-8.Peer-Reviewed Original ResearchClinical relevancePolymerase chain reaction testingUncertain clinical relevanceAbdominal painExtraintestinal manifestationsClinical outcomesStool culturesClinical signsControversial pathogenesisPrevalence studyReaction testingSubtype 1Trichrome stainingAnimal studiesSubtype 3Laboratory diagnosisBlastocystis sppDirect smearDiagnostic approachBlastocystis subtypesSubtype variationBlastocystisSubtype informationRecent studiesCurrent study