2022
Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study
Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, Hu GL, Zhou HW, Jia H, Liao YY, Chen C, Ma Q, Wang D, Yan Y, Sun Y, Wang KK, Niu ZJ, Zhang X, Man ZY, Wu YX, Wang L, Li HX, Zhang J, Li CH, Gao WH, Gao K, Lu WH, Desir GV, Delles C, Chen FY, Mu JJ. Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study. Hypertension 2022, 79: 1247-1256. PMID: 35360932, PMCID: PMC9093226, DOI: 10.1161/hypertensionaha.121.18658.Peer-Reviewed Original ResearchConceptsLong-term blood pressure variabilitySubclinical kidney damageAverage real variabilityBlood pressure variabilityLong-term visitCreatinine ratioUrinary albuminMean BPKidney damageCardiovascular diseasePressure variabilityHigh riskCumulative exposureHanzhong Adolescent Hypertension StudyVisit blood pressure variabilityProspective cohort studyGlomerular filtration rateRisk of albuminuriaClinical characteristicsCohort studyOngoing cohortKidney diseaseHypertension StudyFiltration rateAlbuminuria
2017
The serum protein renalase reduces injury in experimental pancreatitis
Kolodecik TR, Reed AM, Date K, Shugrue C, Patel V, Chung SL, Desir GV, Gorelick FS. The serum protein renalase reduces injury in experimental pancreatitis. Journal Of Biological Chemistry 2017, 292: 21047-21059. PMID: 29042438, PMCID: PMC5743078, DOI: 10.1074/jbc.m117.789776.Peer-Reviewed Original ResearchMeSH KeywordsAcinar CellsAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersCalcium SignalingCarbacholCell LineCeruletideEnzyme ActivationFluorescent Antibody Technique, IndirectGene Expression Regulation, EnzymologicHumansHypertensionLigandsMembrane Transport ModulatorsMiceMice, KnockoutMonoamine OxidasePancreasPancreatitisPlasma Membrane Calcium-Transporting ATPasesRecombinant Fusion ProteinsTaurolithocholic AcidConceptsRecombinant human renalaseAcute pancreatitisAcute injuryCell injuryAcinar cell injuryHuman acinar cellsCytosolic calcium levelsPlasma membrane calcium ATPasePancreatitis onsetIschemic injuryWT micePathological increaseHistological changesProtective effectSevere diseaseMurine modelMembrane calcium ATPasePancreatitisCalcium levelsExperimental pancreatitisBile acidsTissue damageRenalaseInjuryCerulein model
2015
Identification of a Receptor for Extracellular Renalase
Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCell LineCytoprotectionDown-RegulationEpidermal Growth FactorEssential HypertensionHumansHypertensionMitogen-Activated Protein KinasesMonoamine OxidasePlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideProtein Interaction Domains and MotifsSignal TransductionConceptsAcute kidney injuryIntrinsic enzymatic activityMAPK signalingExtracellular renalaseHuman proximal tubular cell line HK-2Enzymatic activitySingle nucleotide gene polymorphismsAcute ischemic kidneyWild-type miceProtein-protein interactionsPlasma membrane ATPaseKidney injuryIschemic kidneyEssential hypertensionIschemic injuryCardiac injuryPMCA4b expressionRecombinant renalaseEpidermal growth factorType miceCardiac hypertrophyHK-2Control studyGene polymorphismsCell signaling
2013
Renalase in hypertension and kidney disease
Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.Peer-Reviewed Original ResearchDoes Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGlomerular Filtration RateHumansHypertensionHypertension, RenalKidneyRenal Insufficiency, ChronicConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients
2012
Human renalase: a review of its biology, function, and implications for hypertension
Desir GV, Wang L, Peixoto AJ. Human renalase: a review of its biology, function, and implications for hypertension. International Journal Of Cardiology Cardiovascular Risk And Prevention 2012, 6: 417-426. PMID: 23107895, DOI: 10.1016/j.jash.2012.09.002.Peer-Reviewed Original ResearchConceptsMechanism of actionBlood pressureIschemic acute kidney injuryEnd-stage renal diseaseAcute kidney injuryHeart transplant recipientsChronic kidney diseaseAmbulatory blood pressureGlomerular filtration rateTarget organ injuryNormal control subjectsEnzyme-linked immunosorbent assayCatecholamine-like substancesRenalase deficiencyRenalase levelsKidney injuryTransplant recipientsRenal dopamineAcute administrationChronic administrationRenal diseaseKidney diseaseControl subjectsFiltration ratePlasma levels
2011
Novel insights into the physiology of renalase and its role in hypertension and heart disease
Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseResistant hypertensionSympathetic toneBlood pressureRecombinant renalaseSpontaneously Hypertensive Stroke-PronePlasma renalase levelsRenalase knockout mouseSystolic blood pressureModel of hypertensionPotent antihypertensive agentSevere cardiac hypertrophyRenalase deficiencyRenalase levelsRenal functionUrine catecholaminesEssential hypertensionSalt intakeStroke proneAntihypertensive agentsCatecholamine levelsRenal sodiumSingle dosePlasma levelsRole of renalase in the regulation of blood pressure and the renal dopamine system
Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseDahl salt-sensitive ratsRenal dopamine systemSalt-sensitive ratsRenalase deficiencyBlood pressureKidney diseaseRenalase levelsResistant hypertensionRecombinant renalaseDopamine systemProximal tubular sodium transportStable coronary artery diseaseComparable blood pressurePlasma renalase levelsRole of renalaseMechanisms of hypertensionNormal renal functionTubular sodium transportCoronary artery diseaseElevation of plasmaPotent antihypertensive agentSevere cardiac hypertrophyKnockout mouse modelRenalase expression
2010
Renalase deficiency aggravates ischemic myocardial damage
Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseWild-type miceRenalase deficiencyKnockout micePlasma blood urea nitrogenLevels of renalaseMild ventricular hypertrophyRenalase knockout mouseNormal systolic functionTraditional risk factorsPlasma catecholamine levelsIschemic myocardial damageBlood urea nitrogenCardiac complicationsCardiovascular complicationsSystolic functionVentricular hypertrophyCardioprotective effectsCatecholamine levelsKidney diseaseMyocardial damageMyocardial necrosisRecombinant renalaseRisk factorsCardiac ischemiaThe Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis
Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.Peer-Reviewed Original ResearchConceptsUse of indapamideUrinary calcium excretionThiazide-type diureticsRandomized clinical trialsTreatment of hypertensionEvidence-based useDose-response effectPaucity of dataInitial therapyCalcium excretionHypertensive patientsOlder patientsThiazide diureticsStone recurrencePatient groupClinical trialsDrug classesSafe optionHypertensionDiureticsAvailable evidenceNephrolithiasisHydrochlorothiazideChlorthalidoneSafe track record
2009
A Case of Extreme Hemodynamic Lability and Hypocalcemia
Knauf F, Desir GV, Perazella MA. A Case of Extreme Hemodynamic Lability and Hypocalcemia. The American Journal Of The Medical Sciences 2009, 338: 241-244. PMID: 19590425, DOI: 10.1097/maj.0b013e3181a66af1.Peer-Reviewed Original ResearchRegulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
2008
Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease
Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseBlood pressureAnimal modelsCardiac functionEnd-stage renal diseaseRegulation of renalaseSalt-dependent hypertensionDevelopment of hypertensionSystolic blood pressurePlasma renalaseRenalase deficiencyCatecholamine administrationSympathetic toneRenal diseaseKidney functionSubtotal nephrectomyPlasma catecholaminesCardiovascular diseaseHypertensionLower plasmaRenalaseCatecholaminesDiseaseAbnormalities
1992
Molecular physiology of renal potassium channels.
Desir G. Molecular physiology of renal potassium channels. Seminars In Nephrology 1992, 12: 531-40. PMID: 1475548.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansHypertensionIon Channel GatingKidneyMembrane PotentialsMolecular BiologyPotassium ChannelsConceptsRenal potassium channelsExtensive physiological dataMolecular biological techniquesMolecular physiologyImportant disease statesEnormous diversityK channelsIon channelsMolecular informationCellular proliferationBiological techniquesPotassium channelsRecent appreciationPossible roleDisease statesK transportMajor rolePatch-clamp techniqueDiversityPhysiological dataChannel structurePhysiologyRegulationRoleProliferation