2017
Extracellular renalase protects cells and organs by outside‐in signalling
Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureCatecholaminesCytokinesHeart RateHumansKidneyMonoamine OxidaseNADPH OxidasesNeoplasmsOxidation-ReductionConceptsProtective effectNovel therapeutic strategiesCancer cell growthBlood pressureOrgan injuryJAK/STATHeart rateTherapeutic strategiesToxic injuryCytoprotective actionMitogen-activated protein kinase pathwayRenalaseTranslational opportunitiesTumor cellsCellular actionsProtein kinase BInitial reportProtein kinase pathwayInjuryKinase BOrgansKinase pathwayGrowth-related genesCell growthExtracellular renalase
2013
Renalase in hypertension and kidney disease
Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.Peer-Reviewed Original Research
2008
Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease
Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseBlood pressureAnimal modelsCardiac functionEnd-stage renal diseaseRegulation of renalaseSalt-dependent hypertensionDevelopment of hypertensionSystolic blood pressurePlasma renalaseRenalase deficiencyCatecholamine administrationSympathetic toneRenal diseaseKidney functionSubtotal nephrectomyPlasma catecholaminesCardiovascular diseaseHypertensionLower plasmaRenalaseCatecholaminesDiseaseAbnormalitiesCatecholamines Regulate the Activity, Secretion, and Synthesis of Renalase
Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseExcess catecholaminesPlasma renalase concentrationSystolic pressure increaseSympathetic nervous systemRenalase gene expressionRegulation of catecholaminesAttractive therapeutic modalityRenalase concentrationCatecholamine surgeBlood pressureNormotensive ratsCatecholamine levelsHemodynamic changesPlasma levelsRecombinant renalaseSystemic abnormalitiesRenalase activityCardiac contractilityTherapeutic modalitiesCardiac hypertrophyCatecholamine metabolismHeart rateParenteral administration
2007
Renalase, a new renal hormone: its role in health and disease
Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureCatecholaminesHumansKidneyKidney Failure, ChronicMonoamine OxidaseSympathetic Nervous SystemConceptsChronic kidney diseaseEnd-stage renal diseaseKidney diseaseBlood pressureRenal hormoneRenal diseaseSalt-sensitive Dahl ratsExaggerated blood pressure responseBaseline blood pressureBlood pressure responseSympathetic nervous systemImportant therapeutic modalityRenalase deficiencyCardiovascular riskDahl ratsEssential hypertensionPlasma levelsCardiac functionRecombinant renalaseCardiovascular functionCardiovascular diseaseTherapeutic modalitiesHeart rateRenalase geneAdrenergic stress