Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture
Cheng FY, Fleming JT, Chiang C. Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Developmental Biology 2018, 440: 152-166. PMID: 29792854, PMCID: PMC6014626, DOI: 10.1016/j.ydbio.2018.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell DifferentiationCell DivisionCell ProliferationCells, CulturedCerebellar CortexCerebellar NeoplasmsCerebellumDevelopmental DisabilitiesHedgehog ProteinsMiceNervous System MalformationsNeural Stem CellsNeurogliaNeuronsPurkinje CellsSignal TransductionWnt Signaling PathwayConceptsCerebellar granule neuron precursorsBergmann gliaDay of ablationSevere cerebellar hypoplasiaCentral nervous system architectureCGNP proliferationGranule neuron precursorsRole of ShhBergmann glial fibersNervous system architectureCerebellar hypoplasiaGlial fibersCortical expansionPurkinje cellsNeuron precursorsGlial networkSpecific ablationGliaNeural tissueNeuronal specificationSignificant decreaseCerebellar sizeShh pathwayMutant cerebellumHh pathway