Featured Publications
A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)
Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.Peer-Reviewed Original ResearchConceptsStable chest painChest painPrimary endpointMajor adverse cardiovascular eventsNon-fatal myocardial infarctionAdverse cardiovascular eventsStudy's primary endpointCoronary artery diseaseClinical trial populationsCox regression modelParticipant-level dataSCOT-HEARTCardiovascular eventsCause mortalityHazard ratioPatients 5Artery diseaseFunctional testingPROMISE trialTrial populationMyocardial infarctionLower incidenceStudy populationPainCollected variablesStandardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device
Oikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, Siddique M, Klüner LV, Shirodaria C, Mavrogiannis MC, Thomas S, Fava A, Deanfield J, Channon KM, Neubauer S, Desai MY, Achenbach S, Antoniades C. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular Research 2021, 117: 2677-2690. PMID: 34450625, DOI: 10.1093/cvr/cvab286.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdiposityAdolescentAdultAgedAged, 80 and overAlgorithmsCloud ComputingComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDecision Support TechniquesEnglandFemaleGermanyHeart Disease Risk FactorsHumansInflammationMaleMiddle AgedNomogramsOhioPredictive Value of TestsPrognosisRisk AssessmentTime FactorsYoung AdultConceptsFat attenuation indexPerivascular fat attenuation indexRisk factor-based modelCoronary artery inflammationClinical risk factorsFatal cardiac eventsCoronary artery diseaseCoronary inflammationRisk factorsFAI scorePlaque metricsCardiac eventsArtery inflammationAbsolute riskCoronary arteryClinical careNon-invasive detectionTraditional cardiovascular risk factorsPatient's absolute riskCardiovascular risk factorsFat compositionNet clinical benefitCardiovascular risk predictionDecision curve analysisFirst-line modalityA novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE predictionAssociation of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index
Elnabawi YA, Oikonomou EK, Dey AK, Mancio J, Rodante JA, Aksentijevich M, Choi H, Keel A, Erb-Alvarez J, Teague HL, Joshi AA, Playford MP, Lockshin B, Choi AD, Gelfand JM, Chen MY, Bluemke DA, Shirodaria C, Antoniades C, Mehta NN. Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index. JAMA Cardiology 2019, 4: 885-891. PMID: 31365032, PMCID: PMC6669789, DOI: 10.1001/jamacardio.2019.2589.Peer-Reviewed Original ResearchConceptsPerivascular fat attenuation indexFat attenuation indexBiologic psoriasis therapyBiologic therapyCoronary inflammationSevere psoriasisPsoriasis therapyCoronary plaquesSkin diseasesAnti-tumor necrosis factor αChronic inflammatory skin diseaseDifferent biologic agentsTraditional risk scoresCoronary plaque burdenLow cardiovascular riskProspective cohort studyAnti-inflammatory effectsCoronary artery diseaseInflammatory skin diseaseCoronary atherosclerotic plaquesNecrosis factor αSevere skin diseaseCardiovascular eventsCardiovascular riskCohort study
2024
Young and Older Patients with Acute Myocardial Infarction: Differences in Risk Factors and Angiographic Characteristics
Sagris M, Theofilis P, Mistakidou V, Oikonomou E, Tsioufis K, Tousoulis D. Young and Older Patients with Acute Myocardial Infarction: Differences in Risk Factors and Angiographic Characteristics. Hellenic Journal Of Cardiology 2024 PMID: 38734305, DOI: 10.1016/j.hjc.2024.05.008.Peer-Reviewed Original ResearchPulse wave velocityFlow-mediated dilationSingle-vessel diseaseAngiographic characteristicsMyocardial infarctionAugmentation indexOlder patientsCompared to older patientsRisk factorsMI patientsRates of diabetes mellitusPatient baseline characteristicsYoung MI patientsLower pulse wave velocityBiomarkers of inflammationAge groupsCentral augmentation indexCoronary artery diseaseBlood test resultsRisk factor profileIncidence of myocardial infarctionAcute myocardial infarctionYoung adultsMedian ageYounger age groupsReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisThe Efficacy of Coronary Sinus Reducer in Patients with Refractory Angina: A Systematic Review and Meta-Analysis
Theofilis P, Vlachakis P, Sagris M, Mantzouranis E, Sakalidis A, Soulaidopoulos S, Chasikidis C, Oikonomou E, Tsioufis K, Tousoulis D. The Efficacy of Coronary Sinus Reducer in Patients with Refractory Angina: A Systematic Review and Meta-Analysis. Reviews In Cardiovascular Medicine 2024, 25: 82. DOI: 10.31083/j.rcm2503082.Peer-Reviewed Original ResearchCanadian Cardiovascular Society classCoronary sinus reducerCanadian Cardiovascular SocietyRefractory anginaProcedural successHigher implant success ratesRandom-effects meta-analysis of proportionsRate of periprocedural complicationsMeta-analysis of proportionsImplant success rateRate of periprocedural adverse eventsPeriprocedural adverse eventsMeta-analysisProportion of patientsSystematic reviewCoronary artery diseaseInspection of funnel plotsRandom-effects meta-analysisNewcastle-Ottawa ScaleEgger's regression testBetween-study heterogeneityRisk of biasSecondary endpointsPeriprocedural complicationsTherapeutic challenge
2023
Diabetes Mellitus in Acute Coronary Syndrome
Stampouloglou P, Anastasiou A, Bletsa E, Lygkoni S, Chouzouri F, Xenou M, Katsarou O, Theofilis P, Zisimos K, Tousoulis D, Vavuranakis M, Siasos G, Oikonomou E. Diabetes Mellitus in Acute Coronary Syndrome. Life 2023, 13: 2226. PMID: 38004366, PMCID: PMC10671950, DOI: 10.3390/life13112226.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary artery diseaseCoronary syndromeDiabetes mellitusCoronary artery bypass surgeryPeptide-1 receptor agonistsFuture randomized control trialsCV protective effectsNon-insulin therapiesArtery bypass surgeryCotransporter 2 inhibitorsPercutaneous coronary interventionBest treatment optionPreferred therapeutic strategyBest treatment strategyRandomized control trialSignificant microvascularCardiovascular prognosisMacrovascular complicationsReperfusion strategyBypass surgeryCoronary interventionEndothelial dysfunctionGlycemic statusArtery diseaseThe efficacy of coronary sinus reduction in refractory angina: A meta-analysis
Theofilis P, Oikonomou E, Lampsas S, Sagris M, Tsioufis K, Tousoulis D. The efficacy of coronary sinus reduction in refractory angina: A meta-analysis. European Heart Journal 2023, 44: ehad655.1291. DOI: 10.1093/eurheartj/ehad655.1291.Peer-Reviewed Original ResearchProportion of patientsPercutaneous coronary interventionRefractory anginaCCS classCoronary interventionImplantation successAvailable pharmacological approachesCoronary artery diseaseMain treatment optionSecondary outcomesArtery diseaseCardiovascular endpointsPrimary outcomeFrequent complainsTreatment optionsHigh success rateInterventional approachesAnginaPharmacological approachesMortality ratePatientsPubMed databaseTitle/Literature searchSuccess rateMid-term outcomes in aortic stenosis patients treated with contemporary balloon expandable and self-expanding valves; does valve size have an impact on outcome?
Kalogeras K, Jabbour R, Pracon R, Kabir T, Shannon J, Duncan A, Oikonomou E, Katsianos E, Patel N, Cadiz S, Siasos G, Vavouranakis M, Davies S, Dalby M, Panoulas V. Mid-term outcomes in aortic stenosis patients treated with contemporary balloon expandable and self-expanding valves; does valve size have an impact on outcome? European Heart Journal 2023, 44: ehad655.2224. DOI: 10.1093/eurheartj/ehad655.2224.Peer-Reviewed Original ResearchTranscatheter heart valveSmall aortic annulusBE groupAortic annulusParavalvular regurgitationSE valvesFollow-upSelf-expandingLeft ventricle systolic functionMid-term all-cause mortalityVentricle systolic functionPeri-procedural outcomesMid-term outcomesBalloon-expandable (BEHead-to-head comparisonsCoronary artery diseaseAll-cause mortalityImproved survival ratesRetrospective registrySE patientsSystolic functionBE patientsBaseline demographicsPost-operativelyFollowed-up
2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signalingCardiac Computed Tomography
Oikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.Peer-Reviewed Original ResearchConceptsCardiac computed tomographyComputed tomographyCoronary atherosclerosisCoronary plaque burdenAcute coronary syndromeCoronary artery diseaseFirst-line diagnostic testUnstable coronary plaquesMorphological plaque featuresCoronary syndromeInflammatory burdenArterial inflammationArtery diseaseCoronary lesionsPlaque burdenPlaque featuresPrognostic implicationsCoronary plaquesPerivascular fatHemodynamic significanceVulnerable plaquesDiagnostic testsMajor causeTomographyCurrent role
2017
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammation