2022
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquids
2018
E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders
DeVito E, Buta E, Sofuoglu M. E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders. Addictive Behaviors 2018, 92: 53-57. PMID: 30583091, PMCID: PMC6699503, DOI: 10.1016/j.addbeh.2018.12.013.Peer-Reviewed Original ResearchConceptsElectronic cigarettesNicotine levelsTobacco useTake-home trialOne monthNicotine electronic cigarettesHigh nicotine dependenceComorbid psychiatric disordersSmoking-related outcomesCombustible cigarette useNicotine e-liquidCombustible tobacco useBaseline characteristicsCessation aidCigarette smokersSmoking characteristicsNicotine doseWorse outcomesEC efficacyNicotine dependenceSmokersPsychiatric disordersCigarette useCombustible cigarettesSmokingBiochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers
Jensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers. Pharmacology Biochemistry And Behavior 2018, 173: 36-43. PMID: 30107183, PMCID: PMC6125200, DOI: 10.1016/j.pbb.2018.08.004.Peer-Reviewed Original ResearchConceptsAcute heart rate responseHeart rate responseNicotine infusionHigher nicotine metabolite ratioTobacco harm reduction approachesRate responseGreater withdrawal symptomsNicotine metabolite ratioBlood-based biomarkersNicotine delivery systemsWarrants further investigationHarm reduction approachWithdrawal symptomsCardiovascular functionLower nicotine levelsTobacco useMetabolite ratiosNicotine levelsSmokeless productsHigher cortisolSmokersHR effectsStimulatory effectNicotineDemographic characteristicsAcute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M. Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. Journal Of Psychopharmacology 2018, 32: 986-994. PMID: 29788802, PMCID: PMC6329876, DOI: 10.1177/0269881118773972.Peer-Reviewed Original ResearchConceptsPositive subjective effectsPositive subjective responsesIntravenous nicotineNicotine metabolismSubjective effectsNicotine metabolite ratioYoung adult smokersSlower nicotine metabolismTest sessionsSubjective responsesSevere nicotine withdrawalMenthol inhalationNicotine withdrawalAcute effectsAdult smokersWithdrawal severityNicotine infusionRewarding effectsSmokersSmoking urgesChronic exposureMetabolite ratiosAversive effectsMenthol conditionsElectronic cigarettesE-cigarettes: Impact of E-liquid Components and Device Characteristics on Nicotine Exposure
DeVito EE, Krishnan-Sarin S. E-cigarettes: Impact of E-liquid Components and Device Characteristics on Nicotine Exposure. Current Neuropharmacology 2018, 16: 438-459. PMID: 29046158, PMCID: PMC6018193, DOI: 10.2174/1570159x15666171016164430.Peer-Reviewed Original ResearchConceptsNicotine exposureE-cigarettesNicotine dependenceEffective smoking cessation toolPrimary addictive componentSmoking cessation toolElectronic cigarette useE-liquidsAddictive componentCessation toolNicotine absorptionNicotine useCigarette usePuff topographyNicotine yieldE-liquid constituentsExposureCigarettesE-cigarette use behaviorsCurrent knowledgeUse behaviorsUnderstanding factorsSmokersFactorsCommon factors
2016
Effect of Menthol-preferring Status on Response to Intravenous Nicotine
DeVito EE, Valentine GW, Herman AI, Jensen KP, Sofuoglu M. Effect of Menthol-preferring Status on Response to Intravenous Nicotine. Tobacco Regulatory Science 2016, 2: 317-328. PMID: 28890914, PMCID: PMC5589161, DOI: 10.18001/trs.2.4.4.Peer-Reviewed Original ResearchSmoking urgesPre-existing individual differencesNicotine dosesNicotine-dependent participantsOvernight smoking abstinenceShort-term abstinenceNon-menthol cigarettesIndividual differencesCognitive performanceCigarette smokersOvernight abstinenceNon-menthol cigarette smokersAcute nicotineSmokers' responsesDependent participantsSmoking abstinenceSubjective differencesEffect of mentholIntravenous nicotineAbstinenceMenthol preferenceSmokersPRO useParticipantsUrge
2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responses