2021
Bile reflux and hypopharyngeal cancer
Vageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.Peer-Reviewed Original ResearchConceptsHypopharyngeal cancerAcidic bileHypopharyngeal carcinogenesisBile refluxRisk factorsGastroesophageal reflux diseaseIndependent risk factorSquamous cell cancerUpper aerodigestive tractElevated p53 expressionAnti-apoptotic effectsReflux diseaseLaryngopharyngeal refluxAerodigestive tractCell cancerGastroesophageal refluxateContribution of STAT3Neck cancerPrecancerous lesionsPremalignant changesNeoplastic changesNF-κBDNA damageP53 expressionBile acids
2020
The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model
Vageli DP, Kasle D, Doukas SG, Doukas PG, Sasaki CT. The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. Oncotarget 2020, 11: 3303-3314. PMID: 32934775, PMCID: PMC7476734, DOI: 10.18632/oncotarget.27706.Peer-Reviewed Original ResearchNF-κB inhibitorBAY 11NF-κB-related pathwaysPharmacological NF-κB inhibitorSquamous cell cancerPro-inflammatory effectsNF-κB inhibitionNF-κB activationOncogenic mRNAsAcidic bileTopical preBile refluxHypopharyngeal cancerCell cancerPreclinical modelsTopical administrationHypopharyngeal mucosaBile exposureVivo preventionTranslational explorationMiR-155MiR-21Oncogenic eventsMiRNA phenotypesPrevents overexpression