2016
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters 2016, 26: 5247-5253. PMID: 27720295, DOI: 10.1016/j.bmcl.2016.09.051.Peer-Reviewed Original ResearchConceptsT. brucei infectionBrucei infectionComplex treatment regimensFirst-line drugsNew therapeutic strategiesLeishmania major promastigotesAnti-parasitic potentialTreatment regimensTherapeutic windowTherapeutic strategiesCurrent drugsMajor promastigotesEncouraging initial resultsHuman liverAntibiotic resistanceGreater cytotoxicityProtozoan parasiteKidney cellsMedicinal chemistry optimizationInfectionInhibitorsPotent inhibitorBrucei parasitesDrugsCytotoxicity
2001
Cellular trafficking in trypanosomatids: a new target for therapies?
Costa-Pinto D, Trindade L, McMahon-Pratt D, Traub-Cseko Y. Cellular trafficking in trypanosomatids: a new target for therapies? International Journal For Parasitology 2001, 31: 537-544. PMID: 11334939, DOI: 10.1016/s0020-7519(01)00145-x.Peer-Reviewed Original ResearchConceptsPathogenic trypanosomatidsTrafficking mechanismsLysosomal targetingCellular trafficking mechanismsPlethora of diseasesCellular traffickingTrypanosomatidsTargeting mechanismCysteine proteinasesBiological aspectsNew targetsCurrent knowledgeEfficient vaccineDisease controlTherapyBasic mechanismsTraffickingMechanismTargetParasitesVaccineProteinasesDiseaseTargeting
1998
T cell responses to crude and defined leishmanial antigens in patients from the Lower Amazon region of Brazil infected with different species of Leishmania of the subgenera Leishmania and Viannia
Silveira F, Blackwell J, Ishikawa E, Braga R, Shaw J, Quinnell R, Soong L, Kima P, McMahon‐Pratt D, Black G, Shaw M. T cell responses to crude and defined leishmanial antigens in patients from the Lower Amazon region of Brazil infected with different species of Leishmania of the subgenera Leishmania and Viannia. Parasite Immunology 1998, 20: 19-26. PMID: 9491414, DOI: 10.1046/j.1365-3024.1998.t01-1-00126.x.Peer-Reviewed Original ResearchConceptsT cell responsesDiffuse cutaneous leishmaniasisLeishmanial antigensCell responsesLCL patientsMucocutaneous leishmaniasisMCL patientsCutaneous leishmaniasisL. amazonensis antigensSkin test responsesL. braziliensis antigensSuitable vaccine candidateDCL patientsPoor respondersGood respondersPatient groupBraziliensis antigensSubgenus LeishmaniaAntigen A2Vaccine candidatesPatientsPotent stimulatorA2 antigenAntigenSignificant rise
1996
T-Cell Responsiveness of American Cutaneous Leishmaniasis Patients to PurifiedLeishmania pifanoiAmastigote Antigens andLeishmania braziliensisPromastigote Antigens: Immunologic Patterns Associated with Cure
Coutinho S, Oliveira M, Da-Cruz A, De Luca P, Mendonça S, Bertho A, Soong L, McMahon-Pratt D. T-Cell Responsiveness of American Cutaneous Leishmaniasis Patients to PurifiedLeishmania pifanoiAmastigote Antigens andLeishmania braziliensisPromastigote Antigens: Immunologic Patterns Associated with Cure. Experimental Parasitology 1996, 84: 144-155. PMID: 8932764, DOI: 10.1006/expr.1996.0100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, ProtozoanAntimonyAntiprotozoal AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCytokinesFemaleHumansInterferon-gammaInterleukin-2Interleukin-4LeishmaniaLeishmania braziliensisLeishmaniasis, CutaneousLymphocyte ActivationMaleMeglumineMeglumine AntimoniateOrganometallic CompoundsT-LymphocytesConceptsT cell responsesEnd of therapyBeneficial T cell responsesCell responsesCytokine productionProliferative responseAmerican cutaneous leishmaniasis patientsType 1 cytokine productionType 2 cytokine productionPeripheral blood mononuclear cellsCutaneous leishmaniasis patientsType 1 cytokinesLymphocyte proliferative responsesBlood mononuclear cellsLow proliferative responseT cell responsivenessMixed type 1T cell stimulationAmerican cutaneous leishmaniasisImmunologic patternActive diseaseReactive CD4Amastigote antigensLeishmaniasis patientsMononuclear cells