2016
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection
Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ. The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. Journal Of Cell Science 2016, 129: 3130-3143. PMID: 27358479, PMCID: PMC5004897, DOI: 10.1242/jcs.185595.Peer-Reviewed Original ResearchMeSH KeywordsAniline CompoundsAnimalsCytokinesDisease Models, AnimalImatinib MesylateImmunoglobulin GLeishmaniaLeishmaniasisMacrophagesMiceModels, BiologicalNitrilesParasitesPhagocytosisPhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-hckPyrimidinesQuinolinesRAW 264.7 CellsSignal TransductionSrc-Family KinasesConceptsAmastigote uptakeObligate intracellular parasite LeishmaniaImmunoglobulin-mediated phagocytosisIntracellular parasite LeishmaniaNovel therapeutic strategiesPersistence of infectionLeishmania infectionIgG-mediated phagocytosisTherapeutic strategiesFc receptorsSmall molecule inhibitorsArg activationDisease severityParasite burdenPrimary macrophagesMacrophagesKinase inhibitorsLeishmaniasisHuman hostDevastating diseaseInfectionParasite LeishmaniaSrc family kinasesPhagocytosisLeishmania
1993
Developmental Life Cycle of Leishmania—Cultivation and Characterization of Cultured Extracellular Amastigotes1
PAN A, DUBOISE S, EPERON S, RIVAS L, HODGKINSON V, TRAUB‐CSEKO Y, MCMAHON‐PRATT D. Developmental Life Cycle of Leishmania—Cultivation and Characterization of Cultured Extracellular Amastigotes1. Journal Of Eukaryotic Microbiology 1993, 40: 213-223. PMID: 8461895, DOI: 10.1111/j.1550-7408.1993.tb04906.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPlethora of proteinsCultured amastigotesDevelopmental life cycleDevelopmental responsesDevelopmental regulationAxenic cultureAxenic linesAmastigote stageBiochemical evidenceLife cycleInfected macrophagesOrganismsEnvironmental parametersLeishmania promastigotesAmastigotesDevelopmental investigationsLeishmaniaProteinParasitesRegulationBiochemistryLinesLeishmania amastigotesCharacterizationLeishmania organisms
1989
A review of the geographic distribution and epidemiology of leishmaniasis in the New World.
Grimaldi G, Tesh R, McMahon-Pratt D. A review of the geographic distribution and epidemiology of leishmaniasis in the New World. American Journal Of Tropical Medicine And Hygiene 1989, 41: 687-725. PMID: 2701633, DOI: 10.4269/ajtmh.1989.41.687.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFlagellar Membrane and Paraxial Rod Proteins of Leishmania: Characterization Employing Monoclonal Antibodies
ISMACH R, CIANCI C, CAULFIELD J, LANGER P, HEIN A, McMAHON‐PRATT D. Flagellar Membrane and Paraxial Rod Proteins of Leishmania: Characterization Employing Monoclonal Antibodies. Journal Of Eukaryotic Microbiology 1989, 36: 617-624. PMID: 2689639, DOI: 10.1111/j.1550-7408.1989.tb01105.x.Peer-Reviewed Original ResearchConceptsDoublet of proteinsImmunocytochemical electron microscopic studyIndirect immunofluorescence experimentsRod proteinsMonoclonal antibody fFlagellar membraneSingle proteinDifferent proteinsFlagellar tipImmunofluorescence experimentsFlagellaParaxial rodProteinMonoclonal antibodiesAntibody FElectron microscopic experimentsMembraneLeishmaniaElectron microscopic studyMoleculesDAMicroscopic experimentsMicroscopic studyMonoclonal antibody techniqueLocalized patchesIdentification, using isoenzyme electrophoresis and monoclonal antibodies, of Leishmania isolated from humans and wild animals of Ecuador.
Mimori T, Grimaldi G, Kreutzer R, Gomez E, McMahon-Pratt D, Tesh R, Hashiguchi Y. Identification, using isoenzyme electrophoresis and monoclonal antibodies, of Leishmania isolated from humans and wild animals of Ecuador. American Journal Of Tropical Medicine And Hygiene 1989, 40: 154-8. PMID: 2919726, DOI: 10.4269/ajtmh.1989.40.154.Peer-Reviewed Original Research
1988
Biology of Leishmania and Leishmaniasis
Furtado T, Goihman-Yahr M, Marghescu S, Grimaldi G, David J, McMahon-Pratt D, Rothenberg A, Rosquete R, Avila-Millán E, Istúriz G, Viloria N, de Borges N, Carrasquero M, de Fernández B, Tapia F, de Albornoz M, Bretaña A, de Brito I, Urquiola G, Pereira J, Martín B, de Gómez M, de Román A, Lugo A, Convit J, Padilha-Gonçalves A, Vale E, Araújo M. Biology of Leishmania and Leishmaniasis. 1988, 782-800. DOI: 10.1007/978-3-642-83360-1_87.Commentaries, Editorials and LettersDifferent clinical manifestationsImmunological characterizationCulture of parasitesBiology of LeishmaniaClinical manifestationsReference centerInternational Reference CentreL. tropicaMonoclonal antibodiesParasite strainsElectron microscopic morphologyNew World LeishmaniaLeishmaniaIsoenzyme patternsBraziliensisDonovaniBiochemical methodsParasitesLeishmaniasisDisease
1987
Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies.
Grimaldi G, David J, McMahon-Pratt D. Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies. American Journal Of Tropical Medicine And Hygiene 1987, 36: 270-87. PMID: 3826486, DOI: 10.4269/ajtmh.1987.36.270.Peer-Reviewed Original ResearchConceptsWide geographic distributionWide geographical distributionWild reservoir hostsSubspecies levelNew World LeishmaniaMolecular markersGeographic distributionL. mexicana complexL. braziliensis complexSpecific monoclonal antibodiesGeographical distributionL. donovani chagasiL. mexicanaMexicana complexReservoir hostsMonoclonal antibodiesParasite identificationBraziliensis complexL. donovani complexMexicanaStocks of LeishmaniaL. braziliensisIsolatesComplexesLeishmaniaCharacterization of Developmentally Regulated Molecules of Leishmania
McMahon-Pratt D, Jaffe C, Kahl L, Langer P, Lohman K, Pan A, Rivas L. Characterization of Developmentally Regulated Molecules of Leishmania. NATO ASI Series 1987, 123-136. DOI: 10.1007/978-3-642-72840-2_14.Peer-Reviewed Original ResearchDevelopmental life cycleMammalian hostsRegulated moleculesParasitic protozoaMechanism of attachmentCell surfaceSpecies-specific antigensSurface membraneLife cycleSandfly vectorGenus LeishmaniaLeishmaniaImmunologic analysisMonoclonal antibodiesPromastigotesProtozoaMacrophagesParasitesAmastigote-specific antigensHostMembraneAlimentary tractAmastigotesMaintenanceIdentification
1985
Brazilian Leishmania stocks phenotypically similar to Leishmania major.
Pacheco R, Jaffe C, Grimaldi G, Marzochi M, McMahon-Pratt D, Momen H. Brazilian Leishmania stocks phenotypically similar to Leishmania major. American Journal Of Tropical Medicine And Hygiene 1985, 34: 1076-84. PMID: 3834794, DOI: 10.4269/ajtmh.1985.34.1076.Peer-Reviewed Original ResearchConceptsEnzyme profilesEnzyme electrophoresisL. mexicanaRestriction enzyme profilesL. donovani speciesIndirect radioimmuneNew World LeishmaniaL. braziliensisSchizodeme analysisL. majorMonoclonal antibodiesCutaneous speciesReference strainsSpeciesDifferent geographic areasMexicanaL. donovaniElectrophoresisLeishmaniaLarge panelSubspeciesBspRIMspIBraziliensisGeographic areas