2023
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt M, Held W, McNiff J, Jain D, Höfer T, Shlomchik W. Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. Immunity 2023, 56: 369-385.e6. PMID: 36720219, PMCID: PMC10182785, DOI: 10.1016/j.immuni.2023.01.003.Peer-Reviewed Original ResearchConceptsHost diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationChronic antigen stimulationStem cell transplantationAlloreactive effectorsAdoptive transferCell transplantationΑβ TAntigen stimulationCell exhaustionGVHDRecipient tissuesEffector poolMajor causeCell clonesTarget tissuesAffected tissuesDiseaseGraftTissueTCF-1CellsDiseased tissuesMorbidity
2008
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 2008, 111: 5242-5251. PMID: 18285547, PMCID: PMC2384145, DOI: 10.1182/blood-2007-09-107953.Peer-Reviewed Original ResearchConceptsSecondary lymphoid tissuesT cellsMemory phenotype CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationHost disease inductionCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsT cell traffickingGVHD initiationMild GVHDHost diseaseTransplant recipientsTumor effectCell transplantationLymphoid tissueGVHDDisease inductionImmune responseCD62LCCR7Major causeGraft
2004
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 2004, 105: 2227-2234. PMID: 15522961, DOI: 10.1182/blood-2004-08-3032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalGraft vs Host DiseaseIntestinal DiseasesMembrane GlycoproteinsMiceMice, Inbred BALB COrgan SpecificitySkin DiseasesTransplantation, HomologousConceptsHost antigen-presenting cellsAntigen-presenting cellsDonor antigen-presenting cellsChronic GVHDAcute GVHDHost diseaseAPC requirementsHost-derived antigen-presenting cellsAllogeneic stem cell transplantationMurine chronic graftCD8 T cellsStem cell transplantationChronic graftGVHD therapyCell transplantationChronic formCostimulatory moleculesGVHDT cellsTarget organsAPC functionCD80/86Pathogenesis mechanismsCD4Graft
2003
Chronic liver graft-versus-host disease presenting as acute hepatitis
Shinoura S, Jain D, Cooper D, Seropian S, Robert M. Chronic liver graft-versus-host disease presenting as acute hepatitis. The American Journal Of Gastroenterology 2003, 98: s102-s102. DOI: 10.1111/j.1572-0241.2003.08036.x.Peer-Reviewed Original Research