2024
Treatment resistant depression in a young female successfully treated with a combination of ketamine and pramipexole – A case report
Ibrahim W, Yang Y, Matuskey D. Treatment resistant depression in a young female successfully treated with a combination of ketamine and pramipexole – A case report. Psychiatry Research Case Reports 2024, 3: 100228. DOI: 10.1016/j.psycr.2024.100228.Peer-Reviewed Original ResearchTreatment-resistant depressionForced swim testResistant depressionAntidepressant medicationAdequate trial of antidepressant medicationClasses of antidepressant medicationsTrials of antidepressant medicationsMesolimbic dopaminergic pathwayPatients' depressive symptomsD2/3 receptorsSwim testMood stabilizersDopaminergic pathwaysElectroconvulsive therapyDepressive symptomsAdequate trialKetamine infusionDopamine deficiencyFailure of treatmentDepressionYoung adult femalesPramipexoleCase reportPreclinical studiesKetamine
2023
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar S, Arnone D, Baldwin D, Bloomfield M, Browning M, Cleare A, Corlett P, Deakin J, Erritzoe D, Fu C, Fusar-Poli P, Goodwin G, Hayes J, Howard R, Howes O, Juruena M, Lam R, Lawrie S, McAllister-Williams H, Marwaha S, Matuskey D, McCutcheon R, Nutt D, Pariante C, Pillinger T, Radhakrishnan R, Rucker J, Selvaraj S, Stokes P, Upthegrove R, Yalin N, Yatham L, Young A, Zahn R, Cowen P. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression. Molecular Psychiatry 2023, 28: 3149-3152. PMID: 37322065, PMCID: PMC10618084, DOI: 10.1038/s41380-023-02095-y.Peer-Reviewed Original Research
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations