2020
Carbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
2002
An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression
Oren D, Wisner K, Spinelli M, Epperson C, Peindl K, Terman J, Terman M. An Open Trial of Morning Light Therapy for Treatment of Antepartum Depression. American Journal Of Psychiatry 2002, 159: 666-669. PMID: 11925310, DOI: 10.1176/appi.ajp.159.4.666.Peer-Reviewed Original ResearchConceptsWeeks of treatmentMorning light therapyBright light therapyLight therapyAntepartum depressionOpen trialMajor depressionMorning bright light therapyHamilton Depression Rating ScaleSeasonal Affective Disorder VersionDepression Rating ScaleNovel treatment approachesFollow-up questionnairePregnant patientsAntidepressant effectsPregnant womenDepression ratingsTreatment approachesTherapyRating ScaleAdverse effectsDepressionTrialsWeeksPregnancy
2000
Antidepressant effects of ketamine in depressed patients
Berman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsDepressive Disorder, MajorDose-Response Relationship, DrugDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleGlutamic AcidHumansInjections, IntravenousKetamineMaleMiddle AgedPsychiatric Status Rating ScalesReceptors, N-Methyl-D-AspartateSeverity of Illness IndexConceptsMajor depressionN-methyl-D-aspartate receptor antagonistBrain glutamate systemDouble-blind trialDouble-blind conditionsTreatment of depressionMechanism of actionPlacebo infusionAntidepressant effectsIntravenous treatmentSingle doseReceptor antagonistDepressed patientsGlutamate systemDepressive symptomsPreclinical researchKetamine hydrochlorideDepressionPotential roleTest dayTreatment effectsPatientsKetamineSaline solutionTreatment