2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast MediaImmunityLiverMacrophagesMagnetic Resonance ImagingMiceMice, Inbred C57BLRadiofrequency AblationConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68
2021
Renal plasticity revealed through reversal of polycystic kidney disease in mice
Dong K, Zhang C, Tian X, Coman D, Hyder F, Ma M, Somlo S. Renal plasticity revealed through reversal of polycystic kidney disease in mice. Nature Genetics 2021, 53: 1649-1663. PMID: 34635846, PMCID: PMC9278957, DOI: 10.1038/s41588-021-00946-4.Peer-Reviewed Original ResearchConceptsPKD genesAutosomal dominant polycystic kidney diseaseCyst cell proliferationGene functionPolycystic kidney diseaseCell shapeGenesKidney diseaseExtracellular matrix depositionCell proliferationKidney tubule cellsNormal lumensDominant polycystic kidney diseaseUnexpected capacityPhenotypic featuresCyst progressionMatrix depositionCellsPlasticityCyst formationCystic tubulesMyofibroblast activationProliferationSquamoid cellsKidney results
2016
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior
Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience 2016, 19: 905-914. PMID: 27239938, PMCID: PMC4925298, DOI: 10.1038/nn.4315.Peer-Reviewed Original Research
2012
Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits
Carlyle BC, Duque A, Kitchen RR, Bordner KA, Coman D, Doolittle E, Papademetris X, Hyder F, Taylor JR, Simen AA. Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits. Development And Psychopathology 2012, 24: 1401-1416. PMID: 23062306, PMCID: PMC3681803, DOI: 10.1017/s095457941200079x.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderPost-traumatic stress disorder symptomsMaternal separationEarly life neglectAttentional deficitsHyperactivity disorderDisorder symptomsLife-long problemsCognitive deficitsBehavioral problemsStress-responsive systemsDevelopmental deficitsChild maltreatmentChild neglectBehavioral deficitsDeficitsBehavioral analysisDrug abuseMost researchNeglectSerious public health concernMagnetic resonance imaging
2011
Neuroanatomical changes in a mouse model of early life neglect
Duque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA. Neuroanatomical changes in a mouse model of early life neglect. Brain Structure And Function 2011, 217: 459-472. PMID: 21984312, PMCID: PMC3664301, DOI: 10.1007/s00429-011-0350-9.Peer-Reviewed Original ResearchConceptsMouse modelNeuroanatomical changesEarly life neglectNovel mouse modelNovel animal modelWhite matter disorganizationMaternal separationCortical thicknessAdult miceAnimal modelsBehavioral abnormalitiesInter-hemispheric asymmetrySmall brain sizeSubcortical structuresPharmacological experimentationProtein expressionLeft hemisphereEarly weaningHuman survivorsAbnormalitiesCurrent knowledgeBrain sizeConcomitant changesAtrophy