2022
Comparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors
Khan MH, Mishra SK, Zakaria ABM, Mihailović J, Coman D, Hyder F. Comparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors. Analytical Chemistry 2022, 94: 2536-2545. PMID: 35073049, DOI: 10.1021/acs.analchem.1c04432.Peer-Reviewed Original ResearchConceptsLanthanide macrocyclic complexesParamagnetic lanthanide ionsMagnetic resonance agentsLanthanide complexesMacrocyclic complexesMacrocyclic designDownfield shiftLanthanide ionsNa NMRBulk magnetic susceptibility effectsUnpaired electronChelating agentBiomedical applicationsNegative chargeNMR sensorSodium ionsTriazacyclononaneIonsComplexesBiological importanceMacrocyclicTmDOTPNaCationsGd
2020
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancement
2014
Lanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS)
Huang Y, Coman D, Ali MM, Hyder F. Lanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media & Molecular Imaging 2014, 10: 51-58. PMID: 24801742, PMCID: PMC4222994, DOI: 10.1002/cmmi.1604.Peer-Reviewed Original ResearchConceptsChemical exchange saturation transferLanthanide complexesExchangeable protonsProton resonancesPH imagingLanthanide ion complexesRedundant deviationChemical shift differencesChemical exchange saturation transfer contrastCEST contrastIon complexesChemical shiftsQuantitative pH imagingShift differencesSingle-proton resonancesChemical shift imaging methodsMagnetic resonanceCEST experimentsWater protonsNonexchangeable protonsParamagnetic effectSaturation transferBiosensorComplexesWater resonance