2020
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2008
Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study
Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM. Relation of Reward From Food Intake and Anticipated Food Intake to Obesity: A Functional Magnetic Resonance Imaging Study. Journal Of Psychopathology And Clinical Science 2008, 117: 924-935. PMID: 19025237, PMCID: PMC2681092, DOI: 10.1037/a0013600.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAdolescent girlsGreater activationFunctional magnetic resonance imaging studySomatosensory regionsRelation of rewardGustatory cortexDopamine receptor availabilityMagnetic resonance imaging studyResonance imaging studyChocolate milkshakeTasteless solutionConsequent weight gainFood intakeBrain regionsGreater rewardsHedonic aspectsDecreased activationWeak activationRewardReceptor availabilityMilkshakeGirlsImaging studiesMagnetic resonance imagingModulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment
Bagurdes LA, Mesulam MM, Gitelman DR, Weintraub S, Small DM. Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment. Neuropsychologia 2008, 46: 2943-2948. PMID: 18602410, DOI: 10.1016/j.neuropsychologia.2008.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAnalysis of VarianceAttentionCase-Control StudiesCerebral CortexCognition DisordersDementiaDiscrimination, PsychologicalHumansLimbic SystemMagnetic Resonance ImagingMatched-Pair AnalysisMiddle AgedMotivationReaction TimeReference ValuesRewardSeverity of Illness IndexSpace PerceptionConceptsSpatial attentionSpatial attention networkAttentional shiftsMild cognitive impairmentAttention networkHealthy agingOrbitofrontal cortexCovert attention taskSelective spatial attentionCognitive impairmentUnderlying neural circuitryAD-related declineAttention taskSelective attentionEmotional contentOFC activationPCC activationSpatial cuesSecondary reinforcerInfluence of incentivesPosterior cingulateNeural circuitryNovel eventsCurrent experimentsBehavioral effectsThe Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts
Mohanty A, Gitelman DR, Small DM, Mesulam MM. The Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts. Cerebral Cortex 2008, 18: 2604-2613. PMID: 18308706, PMCID: PMC2567423, DOI: 10.1093/cercor/bhn021.Peer-Reviewed Original ResearchConceptsPosterior parietal cortexSpatial attentionPosterior cingulateAttentional targetsSpatial attention paradigmFood-related cuesStrong functional couplingAttentional biasingAttentional resourcesAttentional shiftsMotivational relevanceAttention paradigmCentral cuesAttention shiftsMotivational salienceMotivational valueMotivational informationMotivational stateMotivational needsIntraparietal sulcusOrbitofrontal cortexParietal cortexFood targetsSelective allocationMultiple domains
2005
Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention
Small DM, Gitelman D, Simmons K, Bloise SM, Parrish T, Mesulam M. Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention. Cerebral Cortex 2005, 15: 1855-1865. PMID: 15746002, DOI: 10.1093/cercor/bhi063.Peer-Reviewed Original ResearchConceptsSpatial expectancyVisual spatial attentionNon-directional cuesCurrent behavioral goalsControl of attentionTarget detection taskFaster reaction timesInferior parietal lobulePosterior cingulate cortexDifferent incentive conditionsValid cuesCentral cuesSpatial attentionMotivational mechanismsNeural processingMotivational incentivesUnimodal cortexBehavioral goalsLimbic mechanismsParietal lobuleAttention networkDetection taskCingulate cortexRelationship of activationIncentive conditions
2003
The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam M. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. NeuroImage 2003, 18: 633-641. PMID: 12667840, DOI: 10.1016/s1053-8119(02)00012-5.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCue benefitPrefrontal cortexPosterior cingulateAttention-related areasNeutral cuesCentral cuesSpatial attentionSpatial expectancyFMRI scanningIrrelevant locationsMotivational valenceGreater activationParietal cortexBrain regionsCuesPeripheral targetsReaction timeCingulateCortexDistractibilityExpectancySignificant eventsAttentionValence