2021
Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity
Perszyk EE, Hutelin Z, Trinh J, Kanyamibwa A, Fromm S, Davis XS, Wall KM, Flack KD, DiFeliceantonio AG, Small DM. Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity. Nutrients 2021, 13: 1203. PMID: 33917347, PMCID: PMC8067354, DOI: 10.3390/nu13041203.Peer-Reviewed Original Research
2020
Identification of a brain fingerprint for overweight and obesity
Farruggia MC, van Kooten MJ, Perszyk EE, Burke MV, Scheinost D, Constable RT, Small DM. Identification of a brain fingerprint for overweight and obesity. Physiology & Behavior 2020, 222: 112940. PMID: 32417645, PMCID: PMC7321926, DOI: 10.1016/j.physbeh.2020.112940.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdultBody Mass IndexBrainHumansObesityOverweightRisk FactorsWaist CircumferenceConceptsPercent body fatWaist circumferenceBody fatWhole-brain functional connectivityBrain network patternsGlucose toleranceBlood insulinObesityOverweightPathophysiological phenotypesFunctional connectivity networksFunctional connectivityMilkshake consumptionBrain correlatesBrain fingerprintsBMIAdiposityBrainCircumferenceConnectivity networksFatDiabetesPathophysiologyCentral roleInsulin
2016
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal
Sun X, Veldhuizen MG, Babbs AE, Sinha R, Small DM. Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal. Chemical Senses 2016, 41: 233-248. PMID: 26826114, PMCID: PMC4850930, DOI: 10.1093/chemse/bjv081.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexHealthy weight subjectsBrain responsesFunctional magnetic resonance imagingMagnetic resonance imagingGhrelin suppressionWeight subjectsMetabolic healthFree fatty acidsMetabolic measuresAnimal studiesBody weightResonance imagingOlfactory-guided behaviorDifferential brain responsesEndocrine influencesChemosensory stimuliMetabolic peptidesMetabolic responseOlfactory sensitivityHuman researchInconsistent resultsMealFatty acids
2014
Working memory and reward association learning impairments in obesity
Coppin G, Nolan-Poupart S, Jones-Gotman M, Small DM. Working memory and reward association learning impairments in obesity. Neuropsychologia 2014, 65: 146-155. PMID: 25447070, PMCID: PMC4259845, DOI: 10.1016/j.neuropsychologia.2014.10.004.Peer-Reviewed Original ResearchConceptsHealthy weight individualsNegative outcomesExplicit learningReward association learningProbabilistic learning taskFunction of groupHealthy weight groupObese individualsReward associationsStimulus-rewardExecutive functionAssociation learningLearning taskExperiment 1Learning impairmentHealthy weightParadoxical preferenceWeight individualsPositive outcomesMemoryWeight groupInfluence of obesitySecond experimentCurrent studyDeficits
2013
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher body mass indexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociation