2007
Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.Peer-Reviewed Original ResearchConceptsPrenatal exposureFemale ratsSpine synapsesPrelimbic cortexDendritic spinesCognitive deficitsLayers II/IIIPrenatal saline controlsExcitatory synaptic inputsAsymmetric spine synapsesPrenatal cocaine exposureRat prelimbic cortexYoung adult malesPhysical disector methodPyramidal neuronsSaline controlsNeuronal activationCocaine exposureExcitatory synapsesFrontal cortexSynaptic inputsAnimal modelsExcess activationPrefrontal cortexCortex
2006
Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors
MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.Peer-Reviewed Original ResearchConceptsDefective androgen receptorHippocampal synaptic responsesEstradiol benzoateAndrogen receptorMale ratsSpine synapsesTfm malesSynaptic responsesAndrogen effectsTfm mutationEffects of EBDose of EBHippocampal CA1 synapsesSpine synapse numberSesame oil vehicleDendritic spine synapsesCA1 stratum radiatumAdult male ratsHippocampal spine synapsesVehicle-injected controlsHormone-induced increaseAgonists/antagonistsWild-type animalsWild-type malesCA1 synapses