2024
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communities
2022
Rhesus Macaque Model of Pulmonary Aging and Non-tuberculous Mycobacterium Infection Reveals Age Related Mechanisms of Disease Severity
Rhoades N, Davies M, Kohama S, Bermudez L, Winthrop K, Mattison J, Fuss C, Spindel E, Messaoudi I. Rhesus Macaque Model of Pulmonary Aging and Non-tuberculous Mycobacterium Infection Reveals Age Related Mechanisms of Disease Severity. 2022, a2155-a2155. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2155.Peer-Reviewed Original Research