2024
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communities
2022
Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques
Rhoades N, Davies M, Lewis S, Cinco I, Kohama S, Bermudez L, Winthrop K, Fuss C, Mattison J, Spindel E, Messaoudi I. Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques. Cell Reports 2022, 39: 110725. PMID: 35443183, PMCID: PMC9096119, DOI: 10.1016/j.celrep.2022.110725.Peer-Reviewed Original ResearchConceptsT cellsCD8<sup>+</sup> T cellsCD8<sup>+</sup> TRhesus macaque modelPulmonary function testsSevere respiratory infectionsSeverity of respiratory diseasePulmonary ageCross-sectional studyMacaque modelInfiltrating macrophagesImmunological landscapeRespiratory infectionsImpact of ageComprehensive cross-sectional studyIncreased riskAge-related changesFunction testsAged animalsIncreased prevalenceHealthy humansRespiratory tractRhesus macaquesConsequence of agingLung