2023
PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohort
2021
PHSOR04 Presentation Time: 10:15 AM Single-Channel Cylinders with Metal Stems: Considerations in Brachytherapy Dose Reporting to Clinical Trials
Tien C. PHSOR04 Presentation Time: 10:15 AM Single-Channel Cylinders with Metal Stems: Considerations in Brachytherapy Dose Reporting to Clinical Trials. Brachytherapy 2021, 20: s24-s25. DOI: 10.1016/j.brachy.2021.06.030.Peer-Reviewed Original ResearchBrachytherapy doseClinical trials
2019
Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.Peer-Reviewed Original ResearchYale-New Haven HospitalPhase II studyBrain metastasesClinical trialsII studyKnife radiosurgeryLocal controlPre-defined primary endpointWhole-brain radiation treatmentFuture prospective clinical trialsEvaluable brain metastasesSymptomatic radiation necrosisMedian patient ageLocal control ratePhase 2 studyGood local controlProspective clinical trialsNumber of metastasesLarge clinical trialsProportional hazards regressionFuture clinical trialsGamma knife radiosurgeryImportant clinical variablesStandard clinical practiceNew Haven Hospital
2017
HDR Monotherapy in Prostate Cancer: Radiobiological Considerations When Determining Biologically Effective Dose in Clinical Trials
Tien C, Carlson D, Nath R, Chen Z. HDR Monotherapy in Prostate Cancer: Radiobiological Considerations When Determining Biologically Effective Dose in Clinical Trials. Brachytherapy 2017, 16: s31. DOI: 10.1016/j.brachy.2017.04.038.Peer-Reviewed Original Research
2011
SU‐E‐T‐204: Real‐Time Monitoring of Age‐Related Macular Degeneration Radiosurgery Using Plastic Scintillation Dosimetry
Tien C, Cantley J, Hintenlang D, Bolch W, Firpo M, Chell E. SU‐E‐T‐204: Real‐Time Monitoring of Age‐Related Macular Degeneration Radiosurgery Using Plastic Scintillation Dosimetry. Medical Physics 2011, 38: 3533-3533. DOI: 10.1118/1.3612154.Peer-Reviewed Original ResearchAge-related macular degenerationTreatment of AMDPhase 1 clinical trialCadaver eye studiesInferior pars planaPre-clinical animal studiesExposure calibration factorsCalibration factorC-arm fluoroscopy unitEye StudyClinical trialsVision lossReal-time measurementMacular degenerationPars planaHigh doseAnimal studiesPlastic waveguidesTotal doseAge 65Real-time monitoringRetinal displacementDoseBlood vesselsMachine head