Christopher Howes, MD
Associate Professor of MedicineCards
About
Research
Publications
2023
Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial
Shah T, McCarthy M, Nasir I, Archer H, Ragheb E, Kluger J, Kashyap N, Paredes C, Patel P, Lu J, Kandel P, Song C, Khan M, Huang H, Haq F, Ahmad R, Howes C, Cambi B, Lancaster G, Cleman M, Dela Cruz C, Parise H, Lansky A. Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial. BMJ Open 2023, 13: e067910. PMID: 36828654, PMCID: PMC9971831, DOI: 10.1136/bmjopen-2022-067910.Peer-Reviewed Original ResearchConceptsStandard of careHigh-intensity rosuvastatinElectronic medical recordsCOVID-19 diseaseMedical recordsPrimary endpointThromboembolic eventsYale New Haven Health SystemSevere COVID-19 diseaseCOVID-19Prespecified primary endpointVenous thromboembolic eventsRisk of progressionCombination of colchicineSafety monitoring boardCare armHispanics/LatinosTherapeutic anticoagulationIndex hospitalisationIll patientsMedian ageFuture trialsEffect of colchicineClinical trialsMonitoring board
2020
Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection
Hummel JP, Maraj I, Taoutel R, Chamoun R, Workman VK, Tran L, Abboud JM, Afif C, Chouairi S, Delvecchio A, Howes CJ, Enriquez AD, Akar JG. Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection. Circulation Arrhythmia And Electrophysiology 2020, 13: e008841-e008841. PMID: 32931318, PMCID: PMC7566294, DOI: 10.1161/circep.120.008841.Peer-Reviewed Original ResearchIncidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin
Maraj I, Hummel JP, Taoutel R, Chamoun R, Workman V, Li C, Tran L, DelVecchio A, Howes C, Akar JG. Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin. Journal Of Cardiovascular Electrophysiology 2020, 31: 1904-1907. PMID: 32485061, PMCID: PMC7300464, DOI: 10.1111/jce.14594.Peer-Reviewed Original ResearchAN UPDATED EXAMINATION OF COMORBIDITIES AMONG PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION
Teng C, Li P, Wu L, Howes C. AN UPDATED EXAMINATION OF COMORBIDITIES AMONG PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2020, 75: 166. DOI: 10.1016/s0735-1097(20)30793-2.Peer-Reviewed Original Research
2014
Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women
Hantsoo L, Czarkowski KA, Child J, Howes C, Epperson CN. Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women. Journal Of Women's Health 2014, 23: 613-618. PMID: 24886268, PMCID: PMC4089019, DOI: 10.1089/jwh.2013.4623.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlood Flow VelocityBrachial ArteryDepression, PostpartumDepressive Disorder, MajorEndothelium, VascularFemaleFollow-Up StudiesHumansMiddle AgedNitric OxidePlatelet AggregationPremenstrual SyndromeSelective Serotonin Reuptake InhibitorsTreatment OutcomeUltrasonography, DopplerVasodilationYoung AdultConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsSSRI treatmentPremenstrual dysphoric disorderCardiovascular diseasePlatelet aggregationNO productionReuptake inhibitorsPostpartum depressionEffects of SSRIsBurden of diseasePlatelet NO productionDepression/anxietyNitric oxide functionSSRI therapyEndothelial functionVascular mechanismsVascular dilatationMajor depressionDysphoric disorderNormal rangeBeck DepressionYounger groupDiseaseWomen
2012
Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells
Jovin IS, Lei L, Huang Y, Hao Z, Curtis JP, Brennan JJ, Remetz MS, Setaro JF, Pfau SE, Howes CJ, Clancy JF, Cabin HS, Cleman MW, Giordano FJ. Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells. Journal Of Cellular And Molecular Medicine 2012, 16: 3022-3027. PMID: 22947374, PMCID: PMC4393730, DOI: 10.1111/j.1582-4934.2012.01629.x.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCoronary thrombectomyCoronary syndromeProgenitor cellsCholesterol crystalsAcute myocardial infarctionEndothelial progenitor cellsFormation of thrombiHaematopoietic progenitor cellsVon Willebrand factorInflammatory cellsEndothelial cell mediumMyocardial infarctionPlaque ruptureThrombectomyImmunohistochemical analysisVascular wallPresence of cellsBlood cellsWillebrand factorThrombus
2007
An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis
Ranjbaran H, Sokol SI, Gallo A, Eid RE, Iakimov AO, D’Alessio A, Kapoor JR, Akhtar S, Howes CJ, Aslan M, Pfau S, Pober JS, Tellides G. An Inflammatory Pathway of IFN-γ Production in Coronary Atherosclerosis. The Journal Of Immunology 2007, 178: 592-604. PMID: 17182600, DOI: 10.4049/jimmunol.178.1.592.Peer-Reviewed Original ResearchConceptsIL-12/ILIFN-gamma-inducible chemokinesCoronary atherosclerosisIL-12IL-18IFN-gammaPlasma levelsT cellsTh1-type cytokine productionHuman atherosclerotic coronary arteriesAcute coronary syndromeSubset of patientsHuman coronary atherosclerosisTh1-type cytokinesC-reactive proteinIFN-γ productionElevated plasma levelsPlasma of patientsInnate immune responseAtherosclerotic coronary arteriesCoronary syndromeSystemic inflammationCardiac catheterizationCardiopulmonary bypassGamma secretion
2006
P5-40 T-wave amplitude is a more sensitive marker of myocardial ischemia than ST-segment changes in patients undergoing exercise stress testing
Naidu S, Shusterman V, Howes C, Cleman M, O’Connor M, Goldberg A, Lampert R. P5-40 T-wave amplitude is a more sensitive marker of myocardial ischemia than ST-segment changes in patients undergoing exercise stress testing. Heart Rhythm 2006, 3: s273. DOI: 10.1016/j.hrthm.2006.02.818.Peer-Reviewed Original Research
2004
Coronary vasospasm during an adenosine stress test
Weissman G, Scandrett RM, Howes CJ, Russell RR. Coronary vasospasm during an adenosine stress test. Journal Of Nuclear Cardiology 2004, 11: 747-750. PMID: 15592199, DOI: 10.1016/j.nuclcard.2004.09.004.Peer-Reviewed Original ResearchComparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris
Patel PB, Pfau SE, Cleman MW, Brennan JJ, Howes C, Remetz M, Cabin HS, Setaro JF, Rinder HM. Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris. The American Journal Of Cardiology 2004, 93: 410-413. PMID: 14969612, DOI: 10.1016/j.amjcard.2003.10.033.Peer-Reviewed Original ResearchConceptsNeutrophil-platelet conjugatesPlatelet activationAngina pectorisCoronary angiographyCoronary sinusLeukocyte-platelet conjugatesDiagnostic coronary angiographyStable angina pectorisCoronary artery diseaseChest painArtery diseaseCardiac catheterizationCoronary arteryCoronary circulationCoronary bedAortic rootBlood samplesPatientsMonocyte-platelet bindingPectorisSimilar degreeAngiographySinusActivation stateNeutrophils
Academic Achievements & Community Involvement
Clinical Care
Overview
Christopher Howes, MD, is a cardiologist and interventional cardiologist who has dedicated his career to providing care to patients, including cardiovascular wellness care. He specializes in atherosclerosis, congestive heart failure, hypertension, and heart disease in women.
Dr. Howes became a cardiologist because he wanted to help people. “Every day we see positive outcomes,” he says.
In addition to caring for patients, Dr. Howes is chief of cardiology, and director of cardiac catheterization and intervention for Greenwich Hospital, which is part of Yale New Haven Health. He participates in multicenter clinical trials in the Yale New Haven Hospital Catheterization Laboratory, investigating new techniques and new devices. He has been recognized as a Castle Connolly Top Doctor.
Clinical Specialties
Interventional Cardiology; Cardiovascular Medicine
Fact Sheets
Coronary Artery Disease (CAD)
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale MedicineCoronary Atherosclerosis Treatments
Learn More on Yale MedicineHeart Attack (Myocardial Infarction)
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