2016
Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
Truong TH, Ung PM, Palde PB, Paulsen CE, Schlessinger A, Carroll KS. Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase. Cell Chemical Biology 2016, 23: 837-848. PMID: 27427230, PMCID: PMC4958504, DOI: 10.1016/j.chembiol.2016.05.017.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpidermal growth factor receptor kinaseGrowth factor receptor kinaseDetailed functional analysisNew electrostatic interactionsFirst detailed functional analysisKinase regulationS-sulfenylationRedox biologyReceptor kinaseCatalytic loopGrowth factor receptorMolecular basisChronic oxidative stressKinase activityFunctional analysisCatalytic importanceRedox activationFactor receptorMajor classesOxidative stressCatalytic efficiencyData highlightMolecular dynamics simulationsActivation
2011
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Paulsen CE, Truong TH, Garcia FJ, Homann A, Gupta V, Leonard SE, Carroll KS. Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity. Nature Chemical Biology 2011, 8: 57-64. PMID: 22158416, PMCID: PMC3528018, DOI: 10.1038/nchembio.736.Peer-Reviewed Original Research