2022
Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1
Skoko J, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen C, Ma H, Liu Y, Wu H, Harkness T, Furdui C, Manevich Y, Morrison C, Brown E, Normolle D, Spies M, Spies M, Carroll K, Neumann C. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biology 2022, 56: 102443. PMID: 36058112, PMCID: PMC9450138, DOI: 10.1016/j.redox.2022.102443.Peer-Reviewed Original ResearchConceptsRAD51 foci formationFoci formationRedox regulationHomologous recombination DNA repair pathwayHR DNA repairProtein binding partnersPoly (ADP-ribose) polymeraseDNA repair pathwaysDAz-2Rad51 proteinSensitization of cellsRad51 filamentsBinding partnerHomologous recombinationDNA repairCysteine oxidationRepair pathwaysMediator proteinsHuman breast cancer cellsCellular responsesPeroxiredoxin 1Breast cancer cellsDNA damagePRDX1Cys319
2017
138 Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-fatty Acids
Skoko J, Asan A, Woodcock C, Cao J, Gaboriau D, Paulsen C, Attar M, Wingert B, Woodcock S, Schulte J, Ma H, Camacho C, Liu Y, Morrison C, Carroll K, Freeman B, Neumann C. 138 Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-fatty Acids. Free Radical Biology And Medicine 2017, 112: 100-101. DOI: 10.1016/j.freeradbiomed.2017.10.151.Peer-Reviewed Original ResearchOA-NO2Breast cancer cellsPeroxiredoxin 1Sensitization of cellsElectrophilic nitro-fatty acidsCancer cellsHuman breast cancer cellsNitro-fatty acidsPharmacological treatmentBreast cancerDNA damageRAD51 foci formationFoci formationCancerDNA double-strand breaksHomologous recombination repairPrimary targetSensitizationRepairCellsCellular responsesH2AX phosphorylationRecombination repairHomologous recombinationRedox regulation